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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
HRAS 3265 Harvey rat sarcoma viral oncogene homolog  11- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
3298786   1987Cell line : -

Source : -

Sample Type : CRC and breast tumor and adjecent normal tissues

No. of Sample : -

Stage : -

Direct-binding liquid competition radioimmunoassay Up-regulation-Molecular studies have demonstrated increased expression of the Harvey (Ha) ras oncogene in human breast and colon carcinomas.


Gene Details



NC_000011.9 (532242..535561, complement)

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Gene Type protein coding
Gene Family -
Description This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 11
Location 11p15.5
Start 532242  
End 535561  
Strand -  
Gene Sequence

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Length 3320  
OMIM ID 190020   
HGNC ID HGNC:5173   
Unigene ID Hs.37003   
Ensembl ID ENSG00000174775   
PharmGKB ID PA29444   

mRNA Information


mRNA ID XM_003959933.4
Exon complement(<3299..>3320)  
mRNA Sequence

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Length 2157  



CDS Information


   
Location1..1191
CDS Sequence

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CCDS ID CCDS7698.1



Protein Information


      
Protein IDXP_003959982.2
Protein NameHarvey rat sarcoma viral oncogene homolog
Molecular Wt. (Da)42448
Protein Sequence

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Length 396  
Uniprot IDP21912
Ensembl Protein ID ENSP00000364649  



Post-translational Modification Information (Source : HPRD)


Residue Type site
CS-Nitrosylation118
CPalmitoylation181
CPalmitoylation184
CPrenylation186
CS-Nitrosylation118
RADP-Ribosylation128
RADP-Ribosylation135
RADP-Ribosylation41
CMethylation186
CFarnesylation186
CFarnesylation186
SPhosphorylation136
SPhosphorylation145
SPhosphorylation136
SPhosphorylation145

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
185AGTR1107NP_114038.1in vitro;in vivo8753867   
596BCL21045NP_000624.2in vivo10490827   
673BRAF1264NP_004324.2in vitro7   706   312   168   038   880   000   000   
993CDC25A305NP_001780.2in vitro7744247   
995CDC25C1146NP_001781.2yeast 2-hybrid9154803   
2885GRB2150NP_002077.1in vivo11352655   
3643INSR975NP_000199.2in vitro3109943   
3956LGALS11040NP_002296.1in vitro;in vivo11709720   
4301MLLT41164NP_001035090.1yeast 2-hybrid10922060   
4763NF11203AAA59925.1in vitro8628317   
5290PIK3CA1382NP_006209.2in vivo9150145   
5295PIK3R11381NP_852664.1in vivo10212255   
5584PRKCI2105NP_002731.4in vivo10848576   
5604MAP2K11469NP_002746.1in vivo7969158   
5894RAF11265NP_002871.1in vitro;in vivo;yeast 2-hybrid8   530   446   891   169   080   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   
5908RAP1B1546NP_056461.1yeast 2-hybrid8332187   
5921RASA1745NP_002881.1in vitro;in vivo7   628   625   921   968   420   000   000   000   000   
6654SOS11681NP_005624.2in vivo115   609   359   690   470   
7097TLR24323NP_003255.2in vivo15496409   
7409VAV11284NP_005419.2in vivo8554611   
29984RHOD5776NP_055393.1in vitro15187129   
51196PLCE17087NP_057425.3in vitro;yeast 2-hybrid11022048   
54106TLR95685NP_059138.1in vitro;in vivo12867418   


Pathway Information


                                                                                                                                                                                                                                                                                                                                                      
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
AGE-RAGE signaling pathway in diabetic complications hsa04933
Alcoholism hsa05034
Axon guidance hsa04360
B cell receptor signaling pathway hsa04662
Bladder cancer hsa05219
Central carbon metabolism in cancer hsa05230
Chemokine signaling pathway hsa04062
Choline metabolism in cancer hsa05231
Cholinergic synapse hsa04725
Chronic myeloid leukemia hsa05220
Endocytosis hsa04144
Endometrial cancer hsa05213
ErbB signaling pathway hsa04012
Estrogen signaling pathway hsa04915
Fc epsilon RI signaling pathway hsa04664
Focal adhesion hsa04510
FoxO signaling pathway hsa04068
Gap junction hsa04540
Glioma hsa05214
GnRH signaling pathway hsa04912
Hepatitis B hsa05161
Hepatitis C hsa05160
HTLV-I infection hsa05166
Insulin signaling pathway hsa04910
Jak-STAT signaling pathway hsa04630
Longevity regulating pathway - mammal hsa04211
Longevity regulating pathway - multiple species hsa04213
Long-term depression hsa04730
Long-term potentiation hsa04720
MAPK signaling pathway hsa04010
Melanogenesis hsa04916
Melanoma hsa05218
MicroRNAs in cancer hsa05206
Natural killer cell mediated cytotoxicity hsa04650
Neurotrophin signaling pathway hsa04722
Non-small cell lung cancer hsa05223
Oxytocin signaling pathway hsa04921
Pathways in cancer hsa05200
Phospholipase D signaling pathway hsa04072
PI3K-Akt signaling pathway hsa04151
Prolactin signaling pathway hsa04917
Prostate cancer hsa05215
Proteoglycans in cancer hsa05205
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014
Regulation of actin cytoskeleton hsa04810
Renal cell carcinoma hsa05211
Serotonergic synapse hsa04726
Signaling pathways regulating pluripotency of stem cells hsa04550
Sphingolipid signaling pathway hsa04071
T cell receptor signaling pathway hsa04660
Thyroid cancer hsa05216
Thyroid hormone signaling pathway hsa04919
Tight junction hsa04530
VEGF signaling pathway hsa04370
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd041383-164  H_N_K_Ras_like
cl214553-164  P-loop_NTPase superfamily
smart0017316-166  RAS
smart0001016-166  small_GTPase
cd0087616-163  Ras
cd0414516-164  M_R_Ras_like
cd0413916-165  RalA_RalB
cd0414416-167  Ras2
cd041753-163  Rap1
cd041773-164  RSR1
cd041363-163  Rap_like
cd041413-170  Rit_Rin_Ric
cd041763-163  Rap2
cd0015416-161  Rab
cd0413716-183  RheB
smart0017516-163  RAB
cd0414616-165  RERG_RasL11_like
cd0186716-165  Rab8_Rab10_Rab13_like
cd0186916-164  Rab1_Ypt1
cd0186316-163  Rab18
cd0414316-179  Rhes_like
cd0412316-163  Rab21
cd0186816-163  Rab11_like
cd0015716-161  Rho
cd0186016-163  Rab5_related
cd0186216-161  Rab7
cd041403-160  ARHI_like
cd0414716-164  Ras_dva
cd0088216-161  Ras_like_GTPase
cd0414816-176  RGK
cd0186116-156  Rab6
cd0411016-177  Rab35
cd0411116-163  Rab39
cd0412716-160  Rab27A
smart0017416-161  RHO
cd0411616-163  Rab9
cd0187516-182  RhoG
cd0186616-163  Rab2
cd0411316-163  Rab4
cd0186428-163  Rab19
cd0411516-169  Rab33B_Rab33A
cd0411242-176  Rab26
cd0413316-161  Rop_like
cd0410143-161  RabL4
cd0411916-163  RJL
cd0411716-164  Rab15
cd0410916-170  Rab28
cd0413016-156  Wrch_1
cd0412927-161  Rho2
cd0412216-165  Rab14
cd0410616-156  Rab23_like
cd0186553-160  Rab3
cd0412042-163  Rab12
cd0187116-163  Rac1_like
cd0413211-168  Rho4_like
cd0187416-156  Cdc42
cd0187016-161  RhoA_like
cd0087754-161  Ran
cd0411442-163  Rab30
cd0413516-156  Tc10
cd0410713-163  Rab32_Rab38
cd0413416-183  Rho3
cd0412144-189  Rab40
pfam0847716-119  Miro
cd0411816-159  Rab24
cd0414214-161  RRP22
cd0412422-167  RabL2
cd0410316-156  Centaurin_gamma
cd0410816-157  Rab36_Rab34
cd0413116-158  Rnd
cd099143-162  RocCOR
cd0417216-157  Rnd3_RhoE_Rho8
cd0187316-161  RhoBTB
cd0417313-172  Rnd2_Rho7
cd0189313-157  Miro1
COG22291-159  Srp102
cd0187896-166  HflX
cd01898110-165  Obg
cd0417416-179  Rnd1_Rho6
cd0412655-172  Rab20
cd01879109-165  FeoB
cd04164101-165  trmE
cd0188743-154  IF2_eIF5B
pfam02421108-163  FeoB_N
cd01854112-154  YjeQ_EngC
cd0088013-166  Era_like
cd0189798-155  NOG
cd0412816-146  Spg1
pfam0000935-163  GTP_EFTU
cd0087813-160  Arf_Arl
cd01890108-163  LepA
PTZ003691-184  PTZ00369
pfam0007116-165  Ras
TIGR0023116-161  small_GTP
COG110016-165  Gem1
PLN0310816-165  PLN03108
PLN0311016-165  PLN03110
PLN0311816-165  PLN03118
PTZ0013248-163  PTZ00132
smart0017653-163  RAN
PLN030714-163  PLN03071
PTZ0009928-156  PTZ00099
PRK00098108-154  PRK00098
PRK12299110-167  obgE
TIGR02729110-166  Obg_CgtA
PRK0529198-166  trmE
COG0370109-163  FeoB
TIGR0315695-153  GTP_HflX
TIGR03918108-154  GTP_HydF
COG226296-166  HflX
PRK12297110-176  obgE
PRK12298110-166  obgE
PRK0416542-114  PRK04165
COG0536110-179  Obg


Ontology Information


   
HPRD ID4069
Molecular ClassGTPase
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO