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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HRG | 3273 | Histidine-rich glycoprotein | 3 | HPRG; HRGP; THPH11 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and control tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis and using spectral counting combined with statistics | Up-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Jul 2008] |
| Chromosome | 3 |
| Location | 3q27 |
| Start | 186665958 |
| End | 186678235 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 12278 |
| OMIM ID | 142640 |
| HGNC ID | HGNC:5181 |
| Unigene ID | Hs.1498 |
| Ensembl ID | ENSG00000113905 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_005247415.3 |
|---|---|
| Exon | join(1..257,2978..3094,3981..4071,5666..5832,6830..6910, 9132..9233,11066..12278) | mRNA Sequence | Download Select all |
| Length | 1964 |
CDS Information
| Location | join(75..257,2978..3094,3981..4071,5666..5832,6830..6910, 9132..9233,11066..11926) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_000403.1 |
|---|---|
| Protein Name | Histidine-rich glycoprotein |
| Molecular Wt. (Da) | 57660 |
| Protein Sequence | Download Select all |
| Length | 525 |
| Uniprot ID | P49662 |
| Ensembl Protein ID | ENSP00000376857 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Disulfide Bridge | 105;126 |
| N | Glycosylation | 125 |
| N | Glycosylation | 202 |
| C | Disulfide Bridge | 203;417 |
| C | Disulfide Bridge | 218;241 |
| C | Disulfide Bridge | 24;504 |
| C | Disulfide Bridge | 78;89 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 712 | C1QA | 393 | NP_057075.1 | in vivo | 9184145 |
| 713 | C1QB | 394 | NP_000482.3 | in vivo | 9184145 |
| 2243 | FGA | 619 | NP_000499.1 | in vivo | 9276466 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00042 | 16-126 | CY |
| cl09238 | 16-126 | CY superfamily |
| smart00043 | 21-127 | CY |
| smart00043 | 144-242 | CY |
| cl09238 | 144-242 | CY superfamily |
Ontology Information
| HPRD ID | 4047 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Cysteine-type peptidase activity (GO:0008234) |
| Biological Process | Apoptosis (GO:0006915) |
Drug Information
No matching records could be found.