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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| APEX1 | 328 | APEX nuclease (multifunctional DNA repair enzyme) 1 | 14 | APE, REF1, HAP1, APX, APEN, REF-1, APE-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23430444 | 2013 | Cell line : - Source : Cancer hospital and the second afiliated Hospital of Harbin Medical University. Sample Type : CRC tumor and normal tissue No. of Sample : 451 CRC and 631 controls Stage : Duke Stage I-IV | PCR-RFLP,Four SNPs | Polymorhpism | - | APE1 (Asp148Glu), PARP1 (Ala762Val), and XRCC1 (Arg399Gln, Arg194Trp) were associated with the susceptibility to CRC, but were not associated with the prognosis of CRC. |
| 25268610 | 2014 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 49 Stage : TNM Stage I-IV. | Real-Time PCR, PCR-RFLP | Polymorhpism | - | Patients with colorectal cancer present expression changes in Several BER genes, suggesting a role for APE1, XRCC1, PARP1 and OGG1 and APE1 polymorphism in colorectal carcinogenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008] |
| Chromosome | 14 |
| Location | 14q11.2 |
| Start | 20923290 |
| End | 20925931 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2642 |
| OMIM ID | 107748 |
| HGNC ID | HGNC:587 |
| Unigene ID | Hs.73722 |
| Ensembl ID | ENSG00000100823 |
| PharmGKB ID | PA201059 |
mRNA Information
| mRNA ID | NM_001641.3 |
|---|---|
| Exon | join(1..264,448..573,784..971,1538..1730,1861..2642) | mRNA Sequence | Download Select all |
| Length | 1563 |
Protein Information
| Protein ID | NP_001632.2 |
|---|---|
| Protein Name | APEX nuclease (multifunctional DNA repair enzyme) 1 |
| Molecular Wt. (Da) | 35423 |
| Protein Sequence | Download Select all |
| Length | 318 |
| Uniprot ID | Q00987 |
| Ensembl Protein ID | ENSP00000258149 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 123 |
| S | Phosphorylation | 123 |
| S | Phosphorylation | 123 |
| K | Proteolytic Cleavage | 31 |
| K | Proteolytic Cleavage | 31 |
| K | Proteolytic Cleavage | 31 |
| K | Acetylation | 6 |
| K | Acetylation | 7 |
| K | Acetylation | 6 |
| K | Acetylation | 7 |
| K | Acetylation | 6 |
| K | Acetylation | 7 |
| Y | Phosphorylation | 262;- |
| Y | Phosphorylation | 262;- |
| Y | Phosphorylation | 262;- |
| K | Acetylation | 197 |
| K | Acetylation | 197 |
| K | Acetylation | 197 |
| Y | Phosphorylation | 184 |
| Y | Phosphorylation | 184 |
| Y | Phosphorylation | 184 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3065 | HDAC1 | 3143 | NP_004955.2 | in vivo | 14633989 |
| 23520 | ANP32C | 6045 | NP_036535.1 | in vitro | 12524539 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Base excision repair | hsa03410 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd09087 | 62-316 | Ape1-like_AP-endo |
| cl00490 | 62-316 | EEP superfamily |
| TIGR00633 | 62-317 | xth |
| cd09073 | 63-316 | ExoIII_AP-endo |
| COG0708 | 62-318 | XthA |
| cd09085 | 62-316 | Mth212-like_AP-endo |
| TIGR00195 | 62-314 | exoDNase_III |
| PRK13911 | 62-316 | PRK13911 |
| cd10281 | 62-314 | Nape_like_AP-endo |
| cd09086 | 62-312 | ExoIII-like_AP-endo |
| cd08372 | 64-316 | EEP |
| cd09088 | 63-312 | Ape2-like_AP-endo |
| pfam03372 | 65-309 | Exo_endo_phos |
| cd09076 | 64-314 | L1-EN |
| PRK11756 | 62-312 | PRK11756 |
| cd09084 | 66-316 | EEP-2 |
| COG3568 | 57-318 | ElsH |
| cd09080 | 62-233 | TDP2 |
| pfam14529 | 165-313 | Exo_endo_phos_2 |
Ontology Information
| HPRD ID | 4082 |
|---|---|
| Molecular Class | DNA repair protein |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P27695 | DB04967 | Lucanthone | SmallMoleculeDrug |