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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
HSD11B1 3290 hydroxysteroid (11-beta) dehydrogenase 1  1SDR26C1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24061267   2013Cell line : -

Source : -

Sample Type : CRC tumor and normal tissues

No. of Sample : 18

Stage : -

-Polymorhpism-Functional polymorphism rs932335 in intron4 of HSD11B1 may influence the susceptibility to and progression of CRC in a Chinese population.


Gene Details



NC_000001.10 (209859525..209908295)

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Gene Type protein coding
Gene Family Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 3
Description The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]  
Chromosome 1
Location 1q32-q41
Start 209859525  
End 209908295  
Strand +  
Gene Sequence

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Length 48771  
OMIM ID 600713   
HGNC ID HGNC:5208   
Unigene ID Hs.195040   
Ensembl ID ENSG00000117594   
PharmGKB ID PA29476   

mRNA Information


mRNA ID NM_001206741.1
Exon join(1..106,18716..18851,19632..19762,20530..20641, 20764..20949,46257..46400,48125..48771)  
mRNA Sequence

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Length 1479  



CDS Information


   
Location155..1033
CDS Sequence

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CCDS ID CCDS1489.1



Protein Information


      
Protein IDNP_001193670.1
Protein Namehydroxysteroid (11-beta) dehydrogenase 1
Molecular Wt. (Da)32270
Protein Sequence

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Length 292  
Uniprot IDQ9UBV2
Ensembl Protein ID ENSP00000337053  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                        
Pathway Name Pathway ID
Chemical carcinogenesis hsa05204
Metabolic pathways hsa01100
Metabolism of xenobiotics by cytochrome P450 hsa00980
Steroid hormone biosynthesis hsa00140


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0533232-279  11beta-HSD1_like_SDR_c
cl2145432-279  NADB_Rossmann superfamily
cd0523337-256  SDR_c
cd0537435-223  17beta-HSD-like_SDR_c
cd0893934-248  KDSR-like_SDR_c
cd0536037-220  SDR_c3
cd0534434-252  BKR_like_SDR_like
cd0893432-221  CAD_SDR_c
cd0535037-221  SDR_c6
cd0536432-193  SDR_c11
cd0533937-221  17beta-HSDXI-like_SDR_c
cd0892935-223  SDR_c4
cd0535634-208  17beta-HSD1_like_SDR_c
cd0532335-247  ADH_SDR_c_like
cd0893628-220  CR_SDR_c
cd0533335-221  BKR_SDR_c
cd0536737-242  SPR-like_SDR_c
cd0980535-210  type2_17beta_HSD-like_SDR_c
cd0534031-226  Ycik_SDR_c
cd0535937-221  ChcA_like_SDR_c
cd0893235-220  HetN_like_SDR_c
cd0536232-221  THN_reductase-like_SDR_c
cd0532932-207  TR_SDR_c
PRK0783235-220  PRK07832
PRK0894528-239  PRK08945
cd0894432-221  SDR_c12
cd0532734-206  retinol-DH_like_SDR_c_like
cd0534732-208  Ga5DH-like_SDR_c
cd0533832-211  DHRS1_HSDL2-like_SDR_c
cd0534635-221  SDR_c5
cd0893532-207  mannonate_red_SDR_c
cd0535532-207  SDR_c1
cd0532435-221  carb_red_PTCR-like_SDR_c
cd0534132-207  3beta-17beta-HSD_like_SDR_c
cd0537032-248  SDR_c2
cd0894034-247  HBDH_SDR_c
cd0535432-259  SDR_c7
cd0893135-238  SDR_c9
PRK1293532-225  PRK12935
cd0893333-190  RDH_SDR_c
PRK0706936-189  PRK07069
PRK0599331-210  PRK05993
cd0535232-221  MDH-like_SDR_c
cd0535832-208  GlcDH_SDR_c
cd0894334-190  R1PA_ADH_SDR_c
PRK0648239-200  PRK06482
cd0535132-191  XR_like_SDR_c
cd0536932-225  TER_DECR_SDR_a
cd0532632-256  secoisolariciresinol-DH_like_SDR_c
cd0534330-225  Mgc4172-like_SDR_c
cd0893732-211  DHB_DH-like_SDR_c
cd0894232-208  RhlG_SDR_c
cd0536537-209  7_alpha_HSDH_SDR_c
PRK0870329-190  PRK08703
cd0536833-207  DHRS6_like_SDR_c
cd0980635-221  type1_17beta-HSD-like_SDR_c
PRK0825135-226  PRK08251
PRK0780629-170  PRK07806
cd0532537-226  carb_red_sniffer_like_SDR_c
cd0534532-224  BKR_3_SDR_c
PRK0694735-221  PRK06947
cd0894538-223  PKR_SDR_c
TIGR0150038-241  sepiapter_red
cd0534831-207  BphB-like_SDR_c
cd0533137-224  DH-DHB-DH_SDR_c
cd0980734-189  retinol-DH_like_SDR_c
cd0534935-228  BKR_2_SDR_c
cd0535332-200  hydroxyacyl-CoA-like_DH_SDR_c-like
cd0536634-221  meso-BDH-like_SDR_c
cd0976332-191  DHRS1-like_SDR_c
PRK0655034-193  fabG
PRK0801735-210  PRK08017
PRK0587634-213  PRK05876
PRK0692435-227  PRK06924
cd0226637-213  SDR
PRK0808532-190  PRK08085
PRK0559937-193  PRK05599
PRK0752332-190  PRK07523
PRK0834036-119  PRK08340
PRK0710234-257  PRK07102
cd0537337-220  SDR_c10
PRK0610137-193  PRK06101
cd0976232-190  HSDL2_SDR_c
PRK1274731-236  PRK12747
PRK0833932-247  PRK08339
cd0532837-173  3alpha_HSD_SDR_c
cd0536332-221  SDH_SDR_c
PRK0612335-221  PRK06123
cd1173037-220  Tthb094_like_SDR_c
cd0535737-207  PR_SDR_c
PRK0973038-229  PRK09730
PRK0788931-237  PRK07889
cd0976134-187  A3DFK9-like_SDR_c
PRK1285932-208  PRK12859
PRK1274632-191  PRK12746
smart0082237-117  PKS_KR
PRK0695335-191  PRK06953
cd0533738-190  BKR_1_SDR_c
PRK0672032-119  PRK06720
pfam1356144-242  adh_short_C2
cd0537234-233  ENR_SDR
pfam0865937-114  KR
cd0533032-229  cyclohexanol_reductase_SDR_c
cd0532233-197  SDH_SDR_c_like
cd0981035-206  LPOR_like_SDR_c_like
cd0537134-192  HSD10-like_SDR_c
PRK0585432-194  PRK05854
cd0527634-121  p53_inducible_oxidoreductase
cl1691234-121  MDR superfamily
cd0980934-170  human_WWOX_like_SDR_c-like
cd0895339-193  KR_2_SDR_x
PRK0841632-243  PRK08416
PRK0869032-198  PRK08690
PRK0745331-119  PRK07453
cd0528934-68  MDR_like_2
cd0827030-69  MDR4
cd0107832-74  NAD_bind_H4MPT_DH
cd0527437-67  KR_FAS_SDR_x
cd1173137-193  Lin1944_like_SDR_c
cd0893033-207  SDR_c8
cd0826834-95  MDR2
cd0895135-207  DR_C-13_KR_SDR_c_like
cd0518834-84  MDR
PRK0886237-88  PRK08862
cd0826634-121  Zn_ADH_like1
PRK0830332-67  PRK08303
cd0824134-117  QOR1
cd0825328-83  zeta_crystallin
TIGR0128932-119  LPOR
cd0826734-83  MDR1
cd0107532-64  NAD_bind_Leu_Phe_Val_DH
PLN0001538-119  PLN00015
smart0099731-64  AdoHcyase_NAD
cd0895033-67  KR_fFAS_SDR_c_like
cd0526939-73  TMR_SDR_a
pfam0010635-201  adh_short
PRK0618134-256  PRK06181
COG102831-221  FabG
COG422130-209  YdfG
PRK0565332-256  fabG
PRK0907232-208  PRK09072
PRK0710931-238  PRK07109
COG030029-268  DltE
PRK0556530-221  fabG
PRK0766630-223  fabG
PRK0732630-193  PRK07326
PRK0782532-257  PRK07825
PRK0723131-190  fabG
PRK1282532-235  fabG
PRK1282632-221  PRK12826
PRK0586628-209  PRK05866
PRK0747831-207  PRK07478
PRK0587232-257  PRK05872
PRK0789031-208  PRK07890
PRK0618031-200  PRK06180
PRK0720132-193  PRK07201
PRK0612427-201  PRK06124
PRK0691435-200  PRK06914
PRK0613932-200  PRK06139
PRK0826339-210  PRK08263
TIGR0183037-221  3oxo_ACP_reduc
PRK0555731-200  fabG
PRK1293931-208  PRK12939
PRK0745429-221  PRK07454
PRK1282932-252  PRK12829
PRK0832427-190  PRK08324
PRK0703532-190  PRK07035
PRK0652332-208  PRK06523
PRK0821332-193  PRK08213
TIGR0196334-200  PHB_DH
PRK1282832-222  PRK12828
PRK0781427-190  PRK07814
PRK0785632-223  PRK07856
PRK0806331-225  PRK08063
PRK0618233-221  PRK06182
PRK1242931-220  PRK12429
PRK0821937-221  PRK08219
PRK0826431-259  PRK08264
PRK0924232-190  PRK09242
PRK0777430-223  PRK07774
PRK0827732-193  PRK08277
PRK0826532-190  PRK08265
PRK0619832-192  PRK06198
TIGR0183232-208  kduD
PRK0798532-208  PRK07985
PRK0578632-190  fabG
PRK067018-197  PRK06701
PRK0862832-210  PRK08628
PRK0822632-209  PRK08226
PRK0826735-239  PRK08267
PRK0706034-228  PRK07060
TIGR0397132-208  SDR_subfam_1
PRK0613832-190  PRK06138
PRK0706328-207  PRK07063
PRK0617931-200  PRK06179
PRK0702436-220  PRK07024
PRK0929134-200  PRK09291
PRK1293632-224  PRK12936
PRK0684132-229  PRK06841
PRK1339432-206  PRK13394
PRK0617231-229  PRK06172
PRK0706232-220  PRK07062
PRK0822031-208  PRK08220
PRK0569337-200  PRK05693
PRK0693532-221  PRK06935
COG396732-257  DltE
PRK0607732-190  fabG
TIGR0241535-200  23BDH
PRK1282333-207  benD
PRK1282732-226  PRK12827
PRK0821732-225  fabG
PRK0893632-208  PRK08936
TIGR0431637-190  dhbA_paeA
PRK1293731-200  PRK12937
PRK0650032-190  PRK06500
PRK0694932-221  PRK06949
PRK0858932-220  PRK08589
PRK0565035-213  PRK05650
PRK0612832-200  PRK06128
PRK0707437-201  PRK07074
TIGR0263228-189  RhaD_aldol-ADH
PRK0620031-207  PRK06200
PRK1248132-209  PRK12481
PRK0611332-227  PRK06113
PRK0648433-221  PRK06484
PRK0612532-193  PRK06125
PRK0709732-201  PRK07097
PRK1274335-192  PRK12743
PRK0767734-119  PRK07677
PRK0585534-220  PRK05855
TIGR0320632-210  benzo_BadH
PRK0827832-217  PRK08278
PRK0913529-207  PRK09135
PRK1274232-192  PRK12742
PRK0777537-210  PRK07775
PRK0617132-208  PRK06171
PRK0586732-209  PRK05867
PLN0278034-208  PLN02780
PRK0864335-192  PRK08643
PRK1282435-223  PRK12824
PRK0639832-202  PRK06398
PRK0826128-187  fabG
PRK1238434-197  PRK12384
PRK0611432-187  PRK06114
PRK0757632-191  PRK07576
PRK0779131-119  PRK07791
PRK0706732-189  PRK07067
PRK0619632-173  PRK06196
TIGR0332532-207  BphB_TodD
PRK0587532-221  PRK05875
PRK0605729-187  PRK06057
PRK0757735-192  PRK07577
PRK0646331-173  fabG
PRK0648429-230  PRK06484
PRK1274832-200  PRK12748
PRK0779232-119  fabG
PLN0225322-200  PLN02253
PRK0571734-190  PRK05717
TIGR0450438-224  SDR_subfam_2
COG060434-112  Qor
PRK0619734-189  PRK06197
TIGR0282433-176  quinone_pig3
TIGR0183137-232  fabG_rel
PRK1053837-209  PRK10538
PRK0864231-200  fabG
PRK0619432-189  PRK06194
PRK0704138-221  PRK07041
PRK1274538-190  PRK12745
COG106434-96  AdhP
TIGR0182938-224  AcAcCoA_reduct
PRK0742432-146  PRK07424
PRK0899332-209  PRK08993
COG062332-198  FabI
PRK0783130-187  PRK07831
PRK0913427-190  PRK09134
PRK0918631-208  PRK09186
COG070235-73  YbjT
COG016932-84  AroE


Ontology Information


   
HPRD ID3079
Molecular ClassEnzyme: Dehydrogenase
Molecular FunctionReceptor binding (GO:0005102)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P28845DB00635PrednisoneSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO