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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
HSPA4 3308 Heat shock 70kDa protein 4  5RY; APG-2; HSPH2; hsp70; hsp70RY; HS24/P52 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19578980   2010Cell line : -

Source : Third Department of Internal Medicine, Semmelweis University

Sample Type : Serum sample

No. of Sample : 179

Stage : -

ELISAUp-regulation-The serum level of soluble HSP70 might prove a useful, stage-independent prognostic marker in colorectal cancer without distant metastasis.


Gene Details



Chromosome: 5; NC_000005.9 (132387662..132440709)

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Gene Type protein coding
Gene Family Heat shock proteins / HSP70
Description -  
Chromosome 5
Location 5q31.1
Start 133051970  
End 133105017  
Strand +  
Gene Sequence

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Length 53048  
OMIM ID 601113   
HGNC ID HGNC:5237   
Unigene ID Hs.90093    
Ensembl ID ENSG00000170606   
PharmGKB ID -   

mRNA Information


mRNA ID NM_002154.3
Exon join(1..388,13011..13068,15448..15588,18405..18527, 21261..21360,22024..22157,24685..24929,34813..34889, 36435..36586,37086..37192,37593..37726,39224..39405, 40731..40820,44129..44281,45192..45317,47576..47683, 49790..49909,51896..52057,52264..53048)  
mRNA Sequence

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Length 3385  



CDS Information


   
Location join(282..388,13011..13068,15448..15588,18405..18527, 21261..21360,22024..22157,24685..24929,34813..34889, 36435..36586,37086..37192,37593..37726,39224..39405, 40731..40820,44129..44281,45192..45317,47576..47683, 49790..49909,51896..52057,52264..52467)
CDS Sequence

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CCDS ID CCDS4166.1



Protein Information


      
Protein IDNP_002145.3
Protein NameHeat shock 70kDa protein 4
Molecular Wt. (Da)94200
Protein Sequence

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Length 840  
Uniprot IDP51878
Ensembl Protein ID ENSP00000260315  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation336;-
SPhosphorylation552;-
SPhosphorylation76
SPhosphorylation76
TPhosphorylation538
TPhosphorylation576
SPhosphorylation415
KAcetylation430
KAcetylation679
KAcetylation272
TPhosphorylation113
TPhosphorylation114
TPhosphorylation118
SPhosphorylation546
SPhosphorylation54
SPhosphorylation58
SPhosphorylation54
SPhosphorylation58
SPhosphorylation384
SPhosphorylation429
SPhosphorylation474
SPhosphorylation777
SPhosphorylation784
TPhosphorylation395
TPhosphorylation776
SPhosphorylation780

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2623GATA12372NP_002040.1in vitro;in vivo17167422   
3838KPNA22818NP_002257.1in vitro10964507   
4306NR3C22991NP_000892.2in vitro9392437   
4973OLR14003NP_002534.1in vitro15792802   
7189TRAF63833NP_665802.1in vitro;in vivo16697380   
8517IKBKG2217NP_001093326.2in vivo16697380   
8841HDAC38950NP_003874.2in vivo11777905   
11098PRSS237149NP_009104.1yeast 2-hybrid16169070   
54541DDIT49662NP_061931.1yeast 2-hybrid16713569   
79577CDC739581NP_078805.3yeast 2-hybrid16169070   


Pathway Information


      
Pathway Name Pathway ID
Antigen processing and presentation hsa04612


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd117372-384  HSPA4_NBD
cl170372-384  NBD_sugar-kinase_HSP70_actin superfamily
cd102282-384  HSPA4_like_NDB
cd117392-384  HSPH1_NBD
cd117382-384  HSPA4L_NBD
cd117325-381  HSP105-110_like_NBD
cd101704-381  HSP70_NBD
cd102334-384  HSPA1-2_6-8-like_NBD
cd102412-379  HSPA5-like_NBD
cd102304-381  HYOU1-like_NBD
cd102343-383  HSPA9-Ssq1-like_NBD
cd117333-383  HSPA9-like_NBD
cd102322-379  ScSsz1p_like_NBD
cd117342-383  Ssq1_like_NBD
cd102382-381  HSPA14-like_NBD
cd102354-381  HscC_like_NBD
cd102363-379  HscA_like_NBD
cd102373-383  HSPA13-like_NBD
cd10225114-377  MreB_like
cd102314-378  YegD_like
pfam000123-607  HSP70
COG04431-434  DnaK
PTZ000094-685  PTZ00009
TIGR023503-399  prok_dnaK
PRK002901-384  dnaK
PRK134113-434  PRK13411
PRK134103-399  PRK13410
CHL000943-399  dnaK
PTZ004003-399  PTZ00400
PLN031843-404  PLN03184
PTZ001863-434  PTZ00186
TIGR019913-379  HscA
PRK051834-383  hscA
PRK014333-379  hscA
PRK13929118-256  PRK13929
pfam06723115-376  MreB_Mbl
TIGR00904135-356  mreB
PTZ00121499-743  PTZ00121
PRK13928126-256  PRK13928
PTZ00121499-741  PTZ00121
COG1077114-356  MreB
PRK13930113-329  PRK13930
PTZ00121492-778  PTZ00121
pfam05483499-701  SCP-1


Ontology Information


   
HPRD ID3459
Molecular ClassChaperone
Molecular FunctionCysteine-type peptidase activity (GO:0008234)
Biological ProcessApoptosis (GO:0006915)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO