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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23830189 | 2013 | Cell line : HCT 15, SW48, SW480, SW620. Source : - Sample Type : - No. of Sample : - Stage : - | 3D colony forming assays, cell cycle analysis, Caspase activity assays, migration assays, matrigel transmigration assays, Western blotting. | Up-regulation | - | Survivin and XIAP to act as radiation resistance factors and further indicate that these apoptosis-regulating proteins are also functioning in cell cycling and cell migration. |
| 25216527 | 2014 | Cell line : HCT116 Source : - Sample Type : - No. of Sample : - Stage : - | Cell transfection,Anchorage-independent growth assay,Flow Cytometry ,Western Blotting, Luciferase Reporter Assay | Up-regulation | - | Overexpression of XIAP protein may contribute to genetic instability associated with cell cycle and checkpoint perturbations, in addition to its impact on cellular apoptosis. |
| 25501831 | 2014 | Cell line : LS 174T,DLD 1,HCT116 Source : - Sample Type : - No. of Sample : - Stage : - | Cell viability assay,Western blotting,siRNA transfection | Up-regulation | - | XIAP-targeting drugs re-sensitize PIK3CA-mutated colorectal cancer cells for death receptor-induced apoptosis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Baculoviral IAP repeat containing |
| Description | This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011] |
| Chromosome | X |
| Location | Xq25 |
| Start | 122993662 |
| End | 123047829 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 54168 |
| OMIM ID | 300079 |
| HGNC ID | HGNC:592 |
| Unigene ID | Hs.356076 |
| Ensembl ID | ENSG00000101966 |
| PharmGKB ID | PA25361 |
mRNA Information
| mRNA ID | NM_001204401.1 |
|---|---|
| Exon | join(1..94,25820..26728,28808..28907,31427..31505, 32920..32962,40682..40882,47177..54168) | mRNA Sequence | Download Select all |
| Length | 8427 |
Protein Information
| Protein ID | NP_001191330.1 |
|---|---|
| Protein Name | X-linked inhibitor of apoptosis |
| Molecular Wt. (Da) | 56554 |
| Protein Sequence | Download Select all |
| Length | 497 |
| Uniprot ID | O00470 |
| Ensembl Protein ID | ENSP00000272369 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 87 |
| S | Phosphorylation | 87 |
| S | Phosphorylation | 40 |
| T | Phosphorylation | 470 |
| T | Phosphorylation | 355 |
| T | Phosphorylation | 356 |
| S | Phosphorylation | 436 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 332 | BIRC5 | 4520 | NP_001012271.1 | in vitro | 15218035 |
| 2935 | GSPT1 | 753 | NP_002085.2 | in vitro;in vivo | 12865429 |
| 7046 | TGFBR1 | 1822 | NP_004603.1 | in vitro | 11356828 |
| 7314 | UBB | 6771 | NP_061828.1 | in vitro;in vivo | 15218035 |
| 55093 | WDYHV1 | 7653 | NP_060494.1 | yeast 2-hybrid | 16189514 |
| 140735 | DYNLL2 | 6489 | NP_542408.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Apoptosis | hsa04210 |
| Focal adhesion | hsa04510 |
| HTLV-I infection | hsa05166 |
| NF-kappa B signaling pathway | hsa04064 |
| Pathways in cancer | hsa05200 |
| Small cell lung cancer | hsa05222 |
| Toxoplasmosis | hsa05145 |
| Ubiquitin mediated proteolysis | hsa04120 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00022 | 164-232 | BIR |
| cl00035 | 164-232 | BIR superfamily |
| cd14395 | 370-419 | UBA_BIRC4_8 |
| cl21463 | 370-419 | UBA_like_SF superfamily |
| cd00022 | 266-331 | BIR |
| cl00035 | 266-331 | BIR superfamily |
| cd00022 | 28-95 | BIR |
| cl00035 | 28-95 | BIR superfamily |
| cd00162 | 450-488 | RING |
| cl17238 | 450-488 | RING superfamily |
| smart00238 | 162-232 | BIR |
| smart00238 | 265-331 | BIR |
| pfam00653 | 166-231 | BIR |
| smart00238 | 26-95 | BIR |
| pfam00653 | 268-331 | BIR |
| pfam00653 | 29-94 | BIR |
| pfam13920 | 446-489 | zf-C3HC4_3 |
| cd14321 | 374-417 | UBA_IAPs |
| cd14394 | 373-420 | UBA_BIRC2_3 |
| pfam13923 | 450-484 | zf-C3HC4_2 |
| cd14396 | 374-417 | UBA_XtBIRC7_like |
Ontology Information
| HPRD ID | 19599 |
|---|---|
| Molecular Class | Enzyme: Ligase |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154) |
Drug Information
No matching records could be found.