Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HSPB1 | 3315 | heat shock 27kDa protein 1 | 7 | HSP27, HSP28, Hs.76067, Hsp25 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19842058 | 2010 | Cell line : - Source : Department of Surgery, the Sixth Peoples Hospital Affiliated to Shanghai Jiao Tong University Sample Type : CRC tumor and control tissue No. of Sample : 6 Stage : - | 2-D Gel electrophoresis, mass spectrometry, Western blotting, Immunohistochemistry | Up-regulation | - | HSP27 might be a potential biomarker for early diagnosis, prognosis, monitoring in the therapy of colorectal carcinoma. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Heat shock proteins / HSPB |
| Description | The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). |
| Chromosome | 7 |
| Location | 7q11.23 |
| Start | 76302558 |
| End | 76304297 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 1740 |
| OMIM ID | 602195 |
| HGNC ID | HGNC:5246 |
| Unigene ID | Hs.520973 |
| Ensembl ID | ENSG00000106211 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001540.3 |
|---|---|
| Exon | join(1..519,1245..1308,1427..1740) | mRNA Sequence | Download Select all |
| Length | 914 |
CDS Information
| Location | join(156..519,1245..1308,1427..1616) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS5583.1 |
Protein Information
| Protein ID | NP_001531.1 |
|---|---|
| Protein Name | heat shock 27kDa protein 1 |
| Molecular Wt. (Da) | 22651 |
| Protein Sequence | Download Select all |
| Length | 205 |
| Uniprot ID | O00219 |
| Ensembl Protein ID | ENSP00000219322 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 15 |
| S | Phosphorylation | 78 |
| S | Phosphorylation | 82 |
| S | Phosphorylation | 83 |
| S | Phosphorylation | 15 |
| S | Phosphorylation | 78 |
| S | Phosphorylation | 82 |
| S | Phosphorylation | 15 |
| S | Phosphorylation | 82 |
| S | Phosphorylation | 78 |
| S | Phosphorylation | 15;- |
| S | Phosphorylation | 82;- |
| S | Phosphorylation | 86;- |
| S | Phosphorylation | 65;- |
| S | Phosphorylation | 199 |
| K | Acetylation | 123 |
| S | Phosphorylation | 135 |
| S | Phosphorylation | 98 |
| S | Phosphorylation | 26 |
| T | Phosphorylation | 113 |
| T | Phosphorylation | 121 |
| T | Phosphorylation | 110 |
| T | Phosphorylation | 174 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 70 | ACTC1 | 15 | NP_005150.1 | in vivo | 12087068 |
| 1409 | CRYAA | 427 | NP_000385.1 | in vitro;in vivo | 11700327 |
| 1410 | CRYAB | 428 | NP_001876.1 | in vitro;in vivo | 156 000 611 700 327 |
| 1415 | CRYBB2 | 430 | NP_000487.1 | in vitro;in vivo | 11700327 |
| 1420 | CRYGC | 435 | NP_066269.1 | in vitro;in vivo | 11700327 |
| 1616 | DAXX | 4424 | NP_001135442.1 | in vivo | 11193028 |
| 1981 | EIF4G1 | 6774 | NP_886553.2 | in vitro | 10859165 |
| 5464 | PPA1 | 1527 | NP_066952.1 | yeast 2-hybrid | 16169070 |
| 7041 | TGFB1I1 | 3831 | NP_001035919.1 | yeast 2-hybrid | 11546764 |
| 7051 | TGM1 | 1824 | NP_000350.1 | in vitro;in vivo | 12100179 |
| 26353 | HSPB8 | 6420 | NP_055180.1 | in vitro;yeast 2-hybrid | 113 425 571 459 479 000 000 000 |
| 51003 | MED31 | 14382 | NP_057144.1 | yeast 2-hybrid | 16169070 |
| 54205 | CYCS | 479 | NP_061820.1 | in vitro | 10980706 |
| 55791 | C1orf103 | 17975 | NP_060842.3 | yeast 2-hybrid | 16169070 |
| 84060 | C7orf64 | 13173 | NP_115496.2 | yeast 2-hybrid | 16169070 |
| 84966 | IGSF21 | 11309 | NP_116269.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amoebiasis | hsa05146 |
| Epstein-Barr virus infection | hsa05169 |
| MAPK signaling pathway | hsa04010 |
| VEGF signaling pathway | hsa04370 |
Structure Information
| PDB ID | 3Q9P |
|---|---|
| Resolution | 2 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | Heat shock protein beta-1 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06475 | 84-169 | ACD_HspB1_like |
| cl00175 | 84-169 | alpha-crystallin-Hsps_p23-like superfamily |
| cd06526 | 93-169 | metazoan_ACD |
| cd06478 | 87-168 | ACD_HspB4-5-6 |
| cd06498 | 87-168 | ACD_alphaB-crystallin_HspB5 |
| cd06497 | 84-168 | ACD_alphaA-crystallin_HspB4 |
| pfam00011 | 87-184 | HSP20 |
| cd06476 | 93-168 | ACD_HspB2_like |
| cd06480 | 95-169 | ACD_HspB8_like |
| cd06464 | 87-168 | ACD_sHsps-like |
| cd00298 | 91-168 | ACD_sHsps_p23-like |
| cd06477 | 95-166 | ACD_HspB3_Like |
| cd06479 | 88-167 | ACD_HspB7_like |
| cd06481 | 92-168 | ACD_HspB9_like |
| cd06482 | 98-168 | ACD_HspB10 |
| cd06470 | 88-144 | ACD_IbpA-B_like |
| cd06471 | 88-171 | ACD_LpsHSP_like |
| PRK10743 | 95-144 | PRK10743 |
| COG0071 | 87-183 | IbpA |
Ontology Information
| HPRD ID | 799 |
|---|---|
| Molecular Class | Chaperone |
| Molecular Function | Growth factor activity (GO:0008083) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.