Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HSP90AA1 | 3320 | Heat shock protein 90kDa alpha (cytosolic), class A member 1 | 14 | EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; HSP89A; HSP90A; HSP90N; HSPCAL1; HSPCAL4 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18497978 | 2008 | Cell line : - Source : - Sample Type : CRC tumor and control tissue No. of Sample : 48 CRC tumor 12 normal tissue Stage : TNM Stag I-IV | Immunohistochemistry, western Blotting | Up-regulation | - | Expression of hsp90N is elevated with progressive dedifferentiation often associated with advanced cancer stages. Specific role of hsp90 overexpression in tumour initiation, progression and metastasis, as well as the nature and cause of such overexpression in specific human tumours may be linked to the activation of specific signalling pathways that results in transcriptional regulation. |
| 20812987 | 2010 | Cell line : - Source : Nanfang Hospital tumour tissue bank. Sample Type : CRC tumor and control tissue No. of Sample : 150 Stage : - | 2-D Gel electrophoresis, and mass spectrometry,Western blotting, Immunohistochemistry | Up-regulation | - | This gene differentially expressed in between normal colorectal tissue and colorectal cancer tissue experiment done by 2-D Gel eclectrophotesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Heat shock proteins / HSPC |
| Description | The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
| Chromosome | 14 |
| Location | 14q32.33 |
| Start | 102080738 |
| End | 102139759 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 59022 |
| OMIM ID | 140571 |
| HGNC ID | HGNC:5253 |
| Unigene ID | Hs.525600 |
| Ensembl ID | ENSG00000080824 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001017963.2 |
|---|---|
| Exon | join(11..510,37675..37885,53382..53543,53636..54002, 54329..54462,54762..55079,55196..55361,55777..55967, 56067..56214,56458..56726,57316..57649,57939..59022) | mRNA Sequence | Download Select all |
| Length | 3887 |
CDS Information
| Location | join(356..510,37678..37885,53382..53543,53636..54002, 54329..54462,54762..55079,55196..55361,55777..55967, 56067..56214,56458..56726,57316..57649,57939..58048) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_005339.3 |
|---|---|
| Protein Name | Heat shock protein 90kDa alpha (cytosolic), class A member 1 |
| Molecular Wt. (Da) | 84529 |
| Protein Sequence | Download Select all |
| Length | 732 |
| Uniprot ID | P55211 |
| Ensembl Protein ID | ENSP00000330237 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 231 |
| T | Phosphorylation | 5 |
| S | Phosphorylation | 353 |
| T | Phosphorylation | 127 |
| T | Phosphorylation | 7 |
| T | Phosphorylation | 129 |
| S | Phosphorylation | 263 |
| S | Phosphorylation | 385 |
| S | Phosphorylation | 263;- |
| S | Phosphorylation | 385;- |
| S | Phosphorylation | 231;- |
| S | Phosphorylation | 353;- |
| S | Phosphorylation | 252;- |
| S | Phosphorylation | 374;- |
| T | Phosphorylation | 725 |
| T | Phosphorylation | 847 |
| S | Phosphorylation | 726 |
| S | Phosphorylation | 848 |
| T | Phosphorylation | 88 |
| T | Phosphorylation | 90 |
| T | Phosphorylation | 210 |
| T | Phosphorylation | 212 |
| K | Acetylation | 362 |
| K | Acetylation | 484 |
| K | Acetylation | 410 |
| K | Acetylation | 532 |
| K | Acetylation | 458 |
| K | Acetylation | 580 |
| K | Acetylation | 407 |
| K | Acetylation | 529 |
| K | Acetylation | 283 |
| K | Acetylation | 405 |
| K | Acetylation | 489 |
| K | Acetylation | 611 |
| K | Acetylation | 443 |
| K | Acetylation | 565 |
| K | Acetylation | 224 |
| K | Acetylation | 346 |
| K | Acetylation | 576 |
| K | Acetylation | 698 |
| K | Acetylation | 292 |
| K | Acetylation | 414 |
| K | Acetylation | 585 |
| K | Acetylation | 707 |
| K | Acetylation | 69 |
| K | Acetylation | 191 |
| K | Acetylation | 558 |
| K | Acetylation | 680 |
| K | Acetylation | 573 |
| K | Acetylation | 695 |
| S | Phosphorylation | 641 |
| S | Phosphorylation | 763 |
| S | Phosphorylation | 315 |
| S | Phosphorylation | 437 |
| T | Phosphorylation | 704 |
| T | Phosphorylation | 708 |
| T | Phosphorylation | 826 |
| T | Phosphorylation | 830 |
| S | Phosphorylation | 709 |
| S | Phosphorylation | 831 |
| S | Phosphorylation | 589 |
| S | Phosphorylation | 711 |
| Y | Phosphorylation | 667 |
| S | Phosphorylation | 673 |
| S | Phosphorylation | 674 |
| Y | Phosphorylation | 789 |
| S | Phosphorylation | 795 |
| S | Phosphorylation | 796 |
| S | Phosphorylation | 677 |
| T | Phosphorylation | 683 |
| S | Phosphorylation | 799 |
| T | Phosphorylation | 805 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 332 | BIRC5 | 4520 | NP_001012271.1 | in vivo | 15894266 |
| 338 | APOB | 133 | NP_000375.2 | in vitro;in vivo | 11333259 |
| 432 | ASGR1 | 151 | NP_001662.1 | in vitro;in vivo | 12167617 |
| 801 | CALM1 | 241 | NP_008819.1 | in vitro;in vivo | 8486648 |
| 862 | RUNX1T1 | 590 | NP_783552.1 | in vitro;in vivo | 10076566 |
| 1459 | CSNK2A2 | 279 | NP_001887.1 | in vitro | 7794926 |
| 2058 | EPRS | 703 | NP_004437.2 | in vitro;in vivo | 10913161 |
| 2099 | ESR1 | 589 | NP_000116.2 | in vivo | 11911945 |
| 2206 | MS4A2 | 915 | NP_000130.1 | in vivo | 19356729 |
| 2534 | FYN | 655 | NP_002028.1 | in vivo | 16888650 |
| 2908 | NR3C1 | 679 | NP_001019265.1 | in vitro | 889 837 593 342 488 000 000 000 000 000 000 000 |
| 2983 | GUCY1B3 | 769 | NP_000848.1 | in vitro;in vivo | 12676772 |
| 3654 | IRAK1 | 2235 | NP_001560.2 | in vitro | 15647277 |
| 3932 | LCK | 1080 | NP_005347.3 | in vivo | 16888650 |
| 4215 | MAP3K3 | 3965 | NP_976226.1 | in vitro | 14743216 |
| 4313 | MMP2 | 386 | NP_004521.1 | in vivo | 15146192 |
| 4842 | NOS1 | 1226 | NP_000611.1 | in vitro;in vivo | 112 847 229 880 522 |
| 5578 | PRKCA | 1498 | NP_002728.1 | in vivo | 19356729 |
| 5580 | PRKCD | 1501 | NP_006245.2 | in vivo | 19356729 |
| 6189 | RPS3A | 1606 | NP_000997.1 | yeast 2-hybrid | 16169070 |
| 6714 | SRC | 1819 | NP_005408.1 | in vivo | 1310678 |
| 6774 | STAT3 | 26 | NP_644805.1 | in vivo | 12559950 |
| 7182 | NR2C2 | 3253 | NP_003289.2 | in vitro | 14743216 |
| 8976 | WASL | 5448 | NP_003932.3 | in vitro;in vivo | 15791211 |
| 9020 | MAP3K14 | 5230 | NP_003945.2 | in vitro | 14743216 |
| 9641 | IKBKE | 5442 | NP_054721.1 | in vivo | 14743216 |
| 29110 | TBK1 | 5322 | NP_037386.1 | in vitro | 14743216 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Antigen processing and presentation | hsa04612 |
| Estrogen signaling pathway | hsa04915 |
| NOD-like receptor signaling pathway | hsa04621 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Progesterone-mediated oocyte maturation | hsa04914 |
| Prostate cancer | hsa05215 |
| Protein processing in endoplasmic reticulum | hsa04141 |
Structure Information
| PDB ID | 1BYQ |
|---|---|
| Resolution | 1.5 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | PROTEIN (HEAT SHOCK PROTEIN 90) |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00075 | 42-190 | HATPase_c |
| cl00075 | 42-190 | HATPase_c superfamily |
| pfam00183 | 196-732 | HSP90 |
| cl20204 | 196-732 | HSP90 superfamily |
| pfam02518 | 40-193 | HATPase_c |
| smart00387 | 40-191 | HATPase_c |
| pfam13589 | 38-158 | HATPase_c_3 |
| PTZ00272 | 18-732 | PTZ00272 |
| PRK05218 | 16-697 | PRK05218 |
| COG0326 | 16-696 | HtpG |
| PTZ00130 | 3-732 | PTZ00130 |
| PRK14083 | 21-416 | PRK14083 |
| TIGR00585 | 45-189 | mutl |
Ontology Information
| HPRD ID | 3122 |
|---|---|
| Molecular Class | Chaperone |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P07900 | DB00615 | Rifabutin | SmallMoleculeDrug |
| P07900 | DB00716 | Nedocromil | SmallMoleculeDrug |