CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20812987	2010	Cell line : - Source : Nanfang Hospital tumour tissue bank. Sample Type : CRC tumor and control tissue No. of Sample : 151 Stage : -	2-D Gel electrophoresis, and mass spectrometry,Western blotting, Immunohistochemistry	Up-regulation	-	This gene differentially expressed in between normal colorectal tissue and colorectal cancer tissue experiment done by 2-D Gel eclectrophotesis In total, 150 patients were involved in the study.

Gene Details

Chromosome: 6; NC_000006.11 (44214849..44221614)
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Gene Type	protein coding
Gene Family	Heat shock proteins / HSPC
Description	This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
Chromosome	6
Location	6p12
Start	44246166
End	44253888
Strand	+
Gene Sequence	>gi\|568815592:44246166-44253888 Homo sapiens chromosome 6, GRCh38.p2 Primary Assembly AGAGGGGGGTCCCCCCCGCAGGTACTCCACTCTCAGTCTGCAAAAGTGTACGCCCGCAGAGCCGCCCCAG GTGCCTGGGTGTTGTGTGATTGACGCGGGGAAGGAGGGGTCAGCCGATCCCTCCCCAACCCTCCATCCCA TCCCTGAGGATTGGGCTGGTACCCGCGTCTCTCGGACAGGTCAGAGCGGGTCGCCGGGTGGGGTCGCTGC AAAAACCCTGCCCCGGCCGCAGCCGGAGAGGCGGAGCCTCGCGGGGAGGGGGCGGGACCGCCGAGACAGG CCTGGAAACTGCTGGAAATGCCGCAGTGCCGCCGCCGCGCCTTCCGCCGCATGTCGGCAAAGAGTCCCCG CCAGCCCCGGCCGGCGCCCTCCCCCTACGCTGAGCTGCCCCTCAGCGCGAACCCTCCGCCCTTCCTCTAC TCCTGCGAGAGTCGGGATCTGGGGCTACCCAAGGTTGGGTCCCGAATGCCAGTCCCTCTGTCGGGACGCG AGATGTGTAGGGCAGATGCTAGGAAGAAGATTGGGTCTGGGAGCGGTGGTCCGCGTGGTTAGCTGCCTCC GCTCTTTTTCGGTGTCCCCCCCAGTCCCGCCCTTGGGTGTGGGGACGCCTGCCCCACAAGTGTTTAGGGA GGTCAGTGGGTTCCTCGCCCGTAGAGACACCGTTTATGCCAAATGAGCACTCCTCATCCCCGCTCTTGAT GGAGTCATGTCCTAGACGTGAAACTATGGGGCTGTGATCACAAGCAAATGTGTGGGCGGATCCGTTGCTT GGGTTCTTCCCCGCCCCCTCTTTTTTTCGGACCATGACGTCAAGGTGGGCTGGTGGCGGCAGGTGCGGGG TTGACAATCATACTCCTTTAAGGCGGAGGGATCTACAGGAGGGCGGCTGTACTGTGCTTCGCCTTATATA GGGCGACTTGGGGCACGCAGTAGCTCTCTCGAGTCACTCCGGCGCAGTGTTGGGACTGTCTGGGTATCGG AAAGCAAGCCTACGTTGCTCACTATTACGTATAATCCTTTTCTTTTCAAGGTAAGGCTGAGATCTCCGCT AGGCTTCTTTCCCTTTAGTGCTGTATTCGTGTTGTTTTTGTTTTTTTCTGTCCTTTAGGGAGCCTTAGTC TAGATGTCGGGGTGGCTTGTGGATAACGCTCTGGATTTTTATAGGGTGAGGGTAGTGGTGGGTGAGGTTT TTTGAGTCCTCCTCGGTTTTCTCTAGTGTGTTTGGGGGGTGGGGCTTTCTCTCGGCGCCTGCTGGCCGTA GCGAGGTGGGCTGTGGGGTTGGGGCAGTGGGCGGCTGGCAGCTGCACGTGGTGGCCGCGCGGCCCGGGAC GCTGCCATTTTTGCCCCTCCACTTCCGGACGCGGCTACGGGGCGTCGGAGGGGGACCGCAGGGTGGCGGG GGTGCCCGCTCGGGTGACTCAGCACGGCCTTGTGGGACTGGCTTTGTCACCTCTCTTATCGGACGCGTTG TTAAAGCCTTCTTGGGTGCTTTGTTTCTGTGAGGGAGGGTTGACGGTGTGGGAAGAGAGCTTTCGGTCTC CAGCACCCGATACTCCCTCCTTCCAGATCTTTCTTGCAGTCCCGGTGGAGGAGGGGCGGGGAGGGGAGCA GGTTCTGGAAGATTCATGGGCTCCTTCCTCCGCCCTTCCTCGAGAGCTGAGATTGTTCTGGAAGCTTCTG GATTCTGGCGCCCCGCCCCAGTGCCCGGATGCTGGGGCGAGGGAGGGTGCACTGCGGCGCCCCCTCCTCG CGTGGTCCTGGCCGACGCATGTCCGGCAGTGACGAGTGTCGGCCTGGTGGCTACGGCCACCATCTTTCTT GGGTTTGGTCCTGTTCTGTAATTTTGTGCTGTGAAAGGGTCGTGGTGGAGCTTTTGGCTTAAGAATTCTT TGTCCGGATTTAATTGCTCCTCCGGTGGGTATCGTATGGATCCCAGGTTATTCCTCCCTGCCCTATGGGG CAGGAGTGTCCCGCCCTTGGACTGGTCTTAGGAACTGACACCTCAGGGGGAGCAGTTTAAAGTTAGTGCC ATTTTTATCTTAAACTAGTCACTTTGATCTCCCCCAAATAAAGAACTGTAGGTAGTGATTTTCACATTTA AATTTGTGTAAGGATTACTTGGGATCTCTAGATACCTGGGTTGGACCAACATTATGATTTTTCTGCCATA CTACCAGATGATGCTGAGGCTGCTGGTCACCATTCTTTAAGTAGGTGGGTTCTGTGACATTTGGTTGAAG AATATTTAGCTTATTTTCTTTTTCCTTCTGAATTTTCAGGCCTCCCACTTAGTGTGTAGTCTGAGATCTT TAAGAGAATGCATTTTTAGTCTTGGGAAGGGATAGTACTCCGGTTAAACCAGTCTGAACTCACTGTCTAA GGTCCTAACAAATGATATGACCTTTAGGATTTTTAAACATGGGGCCTTAGTGTTCTTTTGTAATTAATGA GATTTTTATTTTAGATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGC AGAAATTGCCCAACTCATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAG TTGATCTCTAATGCTTCTGATGTAGGTGCTCTGGTTTCCACATTTGGCATGGTTTTTTTTTTTGATACTC TAGAAGGAGGGGAAAGGAGTGGTTTGGCCTTTGTTGGGGACTACTATTGAAGGGGGTAAACTTGCAGCTA TTCCAAAAAGATGGGTTTTACTCTGGCCATCTTGAACTTGGAAGGGACTATGTCCAGAATAAGTGGGCTC ATGGAACTAACTGGTTCTAAAGCCTCAAGATAGGGGGCAATCAGATTTGAGGCTGAGAGAGGTAAACCAA GATTTTCTTTGAAGATACGGGCTTTAAGAAAGCAAAAGTGGCTGAGCGTGTTGGCTCACACCTGTAATGC CAAGGCAGGAGGATCACTTGAGCCTAGGATTTCGAGGGCAGCCTGGGCAACCGCGAGACCTTGTCTCTGC AAAAAATTAAATATTAGTTGGGCACGGTGGCATGTGCCTGTAGTCCCAGCTACTTGGGAAGCTGGGGTTG GGAGGATGGCTCGAACCTGGGAGGTCAAGGCTGCAGTGAGCTGTCATCCTTGCCACTGCACTGTAGCTTG GGCAACAGAGCAAGAGTCTGTCTTGGAAAGAGCAAAAGTAAGTTGCTGTTTGTATTTCCAGGCCTTGGAC AAGATTCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAGCTGAAAATTGACATCA TCCCCAACCCTCAGGAACGTACCCTGACTTTGGTAGACACAGGCATTGGCATGACCAAAGCTGATCTCAT AAATAATTTGGGAACCATTGCCAAGTCTGGTACTAAAGCATTCATGGAGGCTCTTCAGGTATTGCAGTTC TGTAGGCATTCATACTTATCTGTGTTCTTTGGTTTTTTGCTTCTTTAAAACTTGTGATTGACTTTAAACT TGTTGGCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGG TGGCAGAGAAAGTGGTTGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGG AGGTTCCTTCACTGTGCGTGCTGACCATGGTAAGTTAGCTTTTCTGTTACAAGGTAGTTGGGTTAGGATT TTCTGGGCTCACACCAGTAGCAGAAATTTTGGGCATCCTGTCTGTAAAGCAGTTCTTCACAGCAGTTCTG CTGATACTTACTAATTGCTGGTCTCAACTGCATATACTTTTTACCCTGTTACACGCTTGTAATTGACTCT TCTAGGTGAGCCCATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTA GAAGAGAGGCGGGTCAAAGAAGTAGTGAAGAAGCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATG TGAGTATGGACTTTTAAATCTTTTACACTTAACGTGCAGGATGTTTCCTGTTCTGGAGAATCTCATTGTC CCTGGCTTTTGCTTTCCCTGGTAGTGTTTTGTACTCCAAGGCTAACTTCTGTTTTTGTTACTTAGTTGGA GAAGGAACGAGAGAAGGAAATTAGTGATGATGAGGCAGAGGAAGAGAAAGGTGAGAAAGAAGAGGAAGAT AAAGATGATGAAGAAAAACCCAAGATCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGTAAGGATA AGAAGAAGAAAACTAAGAAGATCAAAGAGAAATACATTGATCAGGAAGAACTAAACAAGACCAAGCCTAT TTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCTACAAGAGCCTCACTAATGAC TGGGAAGACCACTTGGCAGTCAAGGTGTGAGAAGCCTTTGCATGTTGGCTCAACATGCACATATGGAGAG GAATGAGTTAGGTGGAAGAGTGTTGGGTAATAGACACACGGAACTTGTCCAACTGATAACAGAAATGTGA TAGCCATGTGATTTCACTTACTGATTACCCTGTCATAGTGAAGTGCCATCATTTCTAATGACCTCACTTT CTCTTCTTATGGAAATCTGGGTAATGTCTATTGGCAGCCTTACACATCCAGGGTTCTGATCAGAGGGGAC TGTTTTCTACATACAGCTAGTACCCATCTAGATCGTGGAGGGCATTAAGGCTCAGTTTTCTCAGGAGCTG CTTGTTGTGTGTGCTCTATCCCTTAGGCTTAGGGAGGATCATTGTTCCACTTTTAGATAATTTGGTGTTG GGGCTAAAAGGTCCTCTTTTGAAATGTACCACTTATTTTTGGTTTCTTTCAGCACTTTTCTGTAGAAGGT CAGTTGGAATTCAGGGCATTGCTATTTATTCCTCGTCGGGCTCCCTTTGACCTTTTTGAGAACAAGAAGA AAAAGAACAACATCAAACTCTATGTCCGCCGTGTGTTCATCATGGACAGCTGTGATGAGTTGATACCAGA GTATCTCAGTGAGTATCTCCTTGGCCTAATTTAGTTGGGTGAAGTCTTGGGAGGTTTTAGGCATTCTGCT AGGATATTCTAAGGTAACAGTTTTCTGCAATACATAGTAGGTGTAAGGGTTCAGGAGGCTATTAGAGCCT TCTGTTTGAATCTGGGGACCAGGTCTGGTCTAGCTGTTTTTTACTGAGCTTTCTCACCCTGGTTGATGGC AGATTTTATCCGTGGTGTGGTTGACTCTGAGGATCTGCCCCTGAACATCTCCCGAGAAATGCTCCAGCAG AGCAAAATCTTGAAAGTCATTCGCAAAAACATTGTTAAGAAGTGCCTTGAGCTCTTCTCTGAGCTGGCAG AAGACAAGGAGAATTACAAGAAATTCTATGAGGCATTCTCTAAAAATCTCAAGGTAAAAAGGCAAATAAT GCTTATTCCCTTTACCACTTTCTTAGTAATAACAATAAATTATTCCATTCACATTGAAAGTGAAGTTATT GTAGTTAAGCTGGATTGTTTTTCCTCTTCCCACCCTTCAAGCTTGGAATCCACGAAGACTCCACTAACCG CCGCCGCCTGTCTGAGCTGCTGCGCTATCATACCTCCCAGTCTGGAGATGAGATGACATCTCTGTCAGAG TATGTTTCTCGCATGAAGGAGACACAGAAGTCCATCTATTACATCACTGGTGCGTTGACTCTGATTGAAG CCTTTTTGGAGGAGTGGGGAGCACAATTAGGGCTTCCTGGGAACTGGCAGTATGAGGCATTTTAGTCACT GAGTTCATTTAATTACCCTACAGGTGAGAGCAAAGAGCAGGTGGCCAACTCAGCTTTTGTGGAGCGAGTG CGGAAACGGGGCTTCGAGGTGGTATATATGACCGAGCCCATTGACGAGTACTGTGTGCAGCAGCTCAAGG AATTTGATGGGAAGAGCCTGGTCTCAGTTACCAAGGAGGGTCTGGAGCTGCCTGAGGATGAGGAGGAGAA GAAGAAGATGGAAGAGAGCAAGGCAAAGTTTGAGAACCTCTGCAAGCTCATGAAAGAAATCTTAGATAAG AAGGTTGAGAAGGTAAGCCATTCTGGGGCTAGGATATATTTTGTAACATCTTCGAGGTGGGCTCCCTCAC AAGCATGTTTCTATACAATTAGTGGTTTGAGGCAGCCTATTTACTGTTTCATGCCTTCTTGCCTCTTGTT CTCTTCTCTAGTCAGGTTTAAGGCTATTTTAATAAAATTTGGCACAGATTAGGCATTGCTTCAGTTAACT TCTGAGAGTAGATAAAATACCATCATTTTCTTTTTTTTTTCTTTTTTTGAGATGGGGTCTCGCTCTGTCA CCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCATTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTC CTGCCTTAGCCTCCTGAGTAGCTGCCACTACAGGCGCCCGCCACCACACCCCGGCTAATTTTTTGTATTT TTAGTAGAGATGGGGTTTCATCGCGTTAGCCAGGATGGTCTCCATCTCCTGACCTTGTGATTCGCCCACC TCGGCCTCCCAAAGTGCTGGGATTAACAGGCGCAAGCCACCATGCCTGGCCGATTTTTTTTTTTTTTGGA CTGGATCTCGCTCACTGCAAACTCAAGTCTCCTGAGTGGCTGGGATTACAGATGTGTGCTACCACACCCG GTTAATTTTTTGTAGACAGGGTTTTGCCATGTTGGCCAGCATGGTCTCAAACTCAAGTGGTCTGTCCACC TCCTCCCCCTGCTGGAATTAGGCTTGACAATGCCTGTTTTCTCTTTCAAAGTGGTAATGTCAATCTAAGG CTTTTGTGATCGTCCACAGGTGACAATCTCCAATAGACTTGTGTCTTCACCTTGCTGCATTGTGACCAGC ACCTACGGCTGGACAGCCAATATGGAGCGGATCATGAAAGCCCAGGCACTTCGGGACAACTCCACCATGG GCTATATGATGGCCAAAAAGCACCTGGAGATCAACCCTGACCACCCCATTGTGGAGACGCTGCGGCAGAA GGCTGAGGCCGACAAGAATGATAAGGCAGTTAAGGACCTGGTGGTGCTGCTGTTTGAAACCGCCCTGCTA TCTTCTGGCTTTTCCCTTGAGGATCCCCAGACCCACTCCAACCGCATCTATCGCATGATCAAGCTAGGTC TAGGTAAGTAGCTTTGGTACTTGGTGTGGCAAGGAGTTTGTGCAACTCGTCTCCTCTATGGATTTGACTT AATGCTATTTGGTCAAGTCTCACATGGCTTAATTTTACTTCAGGTATTGATGAAGATGAAGTGGCAGCAG AGGAACCCAATGCTGCAGTTCCTGATGAGATCCCCCCTCTCGAGGGCGATGAGGATGCGTCTCGCATGGA AGAAGTCGATTAGGTTAGGAGTTCATAGTTGGAAAACTTGTGCCCTTGTATAGTGTCCCCATGGGCTCCC ACTGCAGCCTCGAGTGCCCCTGTCCCACCTGGCTCCCCCTGCTGGTGTCTAGTGTTTTTTTCCCTCTCCT GTCCTTGTGTTGAAGGCAGTAAACTAAGGGTGTCAAGCCCCATTCCCTCTCTACTCTTGACAGCAGGATT GGATGTTGTGTATTGTGGTTTATTTTATTTTCTTCATTTTGTTCTGAAATTAAAGTATGCAAAATAAAGA ATATGCCGTTTTTATACAGTTCT Download Select all
Length	7723
OMIM ID	140572
HGNC ID	HGNC:5258
Unigene ID	Hs.509736
Ensembl ID	ENSG00000096384
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001271970.1
Exon	join(1..179,2465..2611,3212..3418,3510..3669,3856..3989, 4126..4434,4883..5048,5253..5443,5572..5719,5834..6102, 6880..7213,7324..7723)
mRNA Sequence	>3326 TTTTTCGGACCATGACGTCAAGGTGGGCTGGTGGCGGCAGGTGCGGGGTTGACAATCATACTCC TTTAAGGCGGAGGGATCTACAGGAGGGCGGCTGTACTGTGCTTCGCCTTATATAGGGCGACTTG GGGCACGCAGTAGCTCTCTCGAGTCACTCCGGCGCAGTGTTGGGACTGTCTGGGTATCGGAAAG CAAGCCTACGTTGCTCACTATTACGTATAATCCTTTTCTTTTCAAGATGCCTGAGGAAGTGCAC CATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGCAGAAATTGCCCAACTCATGTCCCTCA TCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGCTTCTGA TGCCTTGGACAAGATTCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAG CTGAAAATTGACATCATCCCCAACCCTCAGGAACGTACCCTGACTTTGGTAGACACAGGCATTG GCATGACCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGGTACTAAAGCATT CATGGAGGCTCTTCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTAT TCTGCCTACTTGGTGGCAGAGAAAGTGGTTGTGATCACAAAGCACAACGATGATGAACAGTATG CTTGGGAGTCTTCTGCTGGAGGTTCCTTCACTGTGCGTGCTGACCATGGTGAGCCCATTGGCAG GGGTACCAAAGTGATCCTCCATCTTAAAGAAGATCAGACAGAGTACCTAGAAGAGAGGCGGGTC AAAGAAGTAGTGAAGAAGCATTCTCAGTTCATAGGCTATCCCATCACCCTTTATTTGGAGAAGG AACGAGAGAAGGAAATTAGTGATGATGAGGCAGAGGAAGAGAAAGGTGAGAAAGAAGAGGAAGA TAAAGATGATGAAGAAAAACCCAAGATCGAAGATGTGGGTTCAGATGAGGAGGATGACAGCGGT AAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGAAATACATTGATCAGGAAGAACTAAACA AGACCAAGCCTATTTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAATTCTA CAAGAGCCTCACTAATGACTGGGAAGACCACTTGGCAGTCAAGCACTTTTCTGTAGAAGGTCAG TTGGAATTCAGGGCATTGCTATTTATTCCTCGTCGGGCTCCCTTTGACCTTTTTGAGAACAAGA AGAAAAAGAACAACATCAAACTCTATGTCCGCCGTGTGTTCATCATGGACAGCTGTGATGAGTT GATACCAGAGTATCTCAATTTTATCCGTGGTGTGGTTGACTCTGAGGATCTGCCCCTGAACATC TCCCGAGAAATGCTCCAGCAGAGCAAAATCTTGAAAGTCATTCGCAAAAACATTGTTAAGAAGT GCCTTGAGCTCTTCTCTGAGCTGGCAGAAGACAAGGAGAATTACAAGAAATTCTATGAGGCATT CTCTAAAAATCTCAAGCTTGGAATCCACGAAGACTCCACTAACCGCCGCCGCCTGTCTGAGCTG CTGCGCTATCATACCTCCCAGTCTGGAGATGAGATGACATCTCTGTCAGAGTATGTTTCTCGCA TGAAGGAGACACAGAAGTCCATCTATTACATCACTGGTGAGAGCAAAGAGCAGGTGGCCAACTC AGCTTTTGTGGAGCGAGTGCGGAAACGGGGCTTCGAGGTGGTATATATGACCGAGCCCATTGAC GAGTACTGTGTGCAGCAGCTCAAGGAATTTGATGGGAAGAGCCTGGTCTCAGTTACCAAGGAGG GTCTGGAGCTGCCTGAGGATGAGGAGGAGAAGAAGAAGATGGAAGAGAGCAAGGCAAAGTTTGA GAACCTCTGCAAGCTCATGAAAGAAATCTTAGATAAGAAGGTTGAGAAGGTGACAATCTCCAAT AGACTTGTGTCTTCACCTTGCTGCATTGTGACCAGCACCTACGGCTGGACAGCCAATATGGAGC GGATCATGAAAGCCCAGGCACTTCGGGACAACTCCACCATGGGCTATATGATGGCCAAAAAGCA CCTGGAGATCAACCCTGACCACCCCATTGTGGAGACGCTGCGGCAGAAGGCTGAGGCCGACAAG AATGATAAGGCAGTTAAGGACCTGGTGGTGCTGCTGTTTGAAACCGCCCTGCTATCTTCTGGCT TTTCCCTTGAGGATCCCCAGACCCACTCCAACCGCATCTATCGCATGATCAAGCTAGGTCTAGG TATTGATGAAGATGAAGTGGCAGCAGAGGAACCCAATGCTGCAGTTCCTGATGAGATCCCCCCT CTCGAGGGCGATGAGGATGCGTCTCGCATGGAAGAAGTCGATTAGGTTAGGAGTTCATAGTTGG AAAACTTGTGCCCTTGTATAGTGTCCCCATGGGCTCCCACTGCAGCCTCGAGTGCCCCTGTCCC ACCTGGCTCCCCCTGCTGGTGTCTAGTGTTTTTTTCCCTCTCCTGTCCTTGTGTTGAAGGCAGT AAACTAAGGGTGTCAAGCCCCATTCCCTCTCTACTCTTGACAGCAGGATTGGATGTTGTGTATT GTGGTTTATTTTATTTTCTTCATTTTGTTCTGAAATTAAAGTATGCAAAATAAAGAATATGCCG TTTTTATACAGTTCT Download Select all
Length	2703

CDS Information

Location	join(2465..2611,3212..3418,3510..3669,3856..3989, 4126..4434,4883..5048,5253..5443,5572..5719,5834..6102, 6880..7213,7324..7433)
CDS Sequence	>gi\|431822404:239-2413 Homo sapiens heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1), transcript variant 2, mRNA ATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACTTTTGCCTTTCAGGCAGAAATTGCCCAAC TCATGTCCCTCATCATCAATACCTTCTATTCCAACAAGGAGATTTTCCTTCGGGAGTTGATCTCTAATGC TTCTGATGCCTTGGACAAGATTCGCTATGAGAGCCTGACAGACCCTTCGAAGTTGGACAGTGGTAAAGAG CTGAAAATTGACATCATCCCCAACCCTCAGGAACGTACCCTGACTTTGGTAGACACAGGCATTGGCATGA CCAAAGCTGATCTCATAAATAATTTGGGAACCATTGCCAAGTCTGGTACTAAAGCATTCATGGAGGCTCT TCAGGCTGGTGCAGACATCTCCATGATTGGGCAGTTTGGTGTTGGCTTTTATTCTGCCTACTTGGTGGCA GAGAAAGTGGTTGTGATCACAAAGCACAACGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGAGGTT CCTTCACTGTGCGTGCTGACCATGGTGAGCCCATTGGCAGGGGTACCAAAGTGATCCTCCATCTTAAAGA AGATCAGACAGAGTACCTAGAAGAGAGGCGGGTCAAAGAAGTAGTGAAGAAGCATTCTCAGTTCATAGGC TATCCCATCACCCTTTATTTGGAGAAGGAACGAGAGAAGGAAATTAGTGATGATGAGGCAGAGGAAGAGA AAGGTGAGAAAGAAGAGGAAGATAAAGATGATGAAGAAAAACCCAAGATCGAAGATGTGGGTTCAGATGA GGAGGATGACAGCGGTAAGGATAAGAAGAAGAAAACTAAGAAGATCAAAGAGAAATACATTGATCAGGAA GAACTAAACAAGACCAAGCCTATTTGGACCAGAAACCCTGATGACATCACCCAAGAGGAGTATGGAGAAT TCTACAAGAGCCTCACTAATGACTGGGAAGACCACTTGGCAGTCAAGCACTTTTCTGTAGAAGGTCAGTT GGAATTCAGGGCATTGCTATTTATTCCTCGTCGGGCTCCCTTTGACCTTTTTGAGAACAAGAAGAAAAAG AACAACATCAAACTCTATGTCCGCCGTGTGTTCATCATGGACAGCTGTGATGAGTTGATACCAGAGTATC TCAATTTTATCCGTGGTGTGGTTGACTCTGAGGATCTGCCCCTGAACATCTCCCGAGAAATGCTCCAGCA GAGCAAAATCTTGAAAGTCATTCGCAAAAACATTGTTAAGAAGTGCCTTGAGCTCTTCTCTGAGCTGGCA GAAGACAAGGAGAATTACAAGAAATTCTATGAGGCATTCTCTAAAAATCTCAAGCTTGGAATCCACGAAG ACTCCACTAACCGCCGCCGCCTGTCTGAGCTGCTGCGCTATCATACCTCCCAGTCTGGAGATGAGATGAC ATCTCTGTCAGAGTATGTTTCTCGCATGAAGGAGACACAGAAGTCCATCTATTACATCACTGGTGAGAGC AAAGAGCAGGTGGCCAACTCAGCTTTTGTGGAGCGAGTGCGGAAACGGGGCTTCGAGGTGGTATATATGA CCGAGCCCATTGACGAGTACTGTGTGCAGCAGCTCAAGGAATTTGATGGGAAGAGCCTGGTCTCAGTTAC CAAGGAGGGTCTGGAGCTGCCTGAGGATGAGGAGGAGAAGAAGAAGATGGAAGAGAGCAAGGCAAAGTTT GAGAACCTCTGCAAGCTCATGAAAGAAATCTTAGATAAGAAGGTTGAGAAGGTGACAATCTCCAATAGAC TTGTGTCTTCACCTTGCTGCATTGTGACCAGCACCTACGGCTGGACAGCCAATATGGAGCGGATCATGAA AGCCCAGGCACTTCGGGACAACTCCACCATGGGCTATATGATGGCCAAAAAGCACCTGGAGATCAACCCT GACCACCCCATTGTGGAGACGCTGCGGCAGAAGGCTGAGGCCGACAAGAATGATAAGGCAGTTAAGGACC TGGTGGTGCTGCTGTTTGAAACCGCCCTGCTATCTTCTGGCTTTTCCCTTGAGGATCCCCAGACCCACTC CAACCGCATCTATCGCATGATCAAGCTAGGTCTAGGTATTGATGAAGATGAAGTGGCAGCAGAGGAACCC AATGCTGCAGTTCCTGATGAGATCCCCCCTCTCGAGGGCGATGAGGATGCGTCTCGCATGGAAGAAGTCG ATTAG Download Select all
CCDS ID	CCDS4909.1

Protein Information

Protein ID	NP_001258898.1
Protein Name	Heat shock protein 90kDa alpha (cytosolic), class B member 1
Molecular Wt. (Da)	83133
Protein Sequence	>3326 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSK LDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQ FGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEY LEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSD EEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKH FSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSE DLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNR RRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVY MTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVE KVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQ KAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAV PDEIPPLEGDEDASRMEEVD Download Select all
Length	724
Uniprot ID	Q92851
Ensembl Protein ID	ENSP00000272879

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	255
S	Phosphorylation	261
Y	Phosphorylation	484;-
Y	Phosphorylation	484;-
S	Phosphorylation	226;-
S	Phosphorylation	255;-
T	Phosphorylation	297;-
Y	Phosphorylation	484;-
S	Phosphorylation	307
S	Phosphorylation	452
S	Phosphorylation	532
S	Phosphorylation	718
K	Acetylation	568
K	Acetylation	435
K	Acetylation	481
S	Phosphorylation	445
Y	Phosphorylation	596
T	Phosphorylation	60
T	Phosphorylation	285
T	Phosphorylation	309
S	Phosphorylation	535
T	Phosphorylation	514

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
207	AKT1	1261	NP_005154.2	in vivo	10995457
392	ARHGAP1	4108	NP_004299.1	yeast 2-hybrid	14697242
2099	ESR1	589	NP_000116.2	in vitro	11795466
6774	STAT3	26	NP_644805.1	in vivo	12559950
7157	TP53	1859	NP_000537.3	in vitro;in vivo	11707401
8976	WASL	5448	NP_003932.3	in vitro;in vivo	15791211
57062	DDX24	5860	NP_065147.1	yeast 2-hybrid	16169070

Pathway Information

Pathway Name	Pathway ID
Antigen processing and presentation	hsa04612
Estrogen signaling pathway	hsa04915
NOD-like receptor signaling pathway	hsa04621
Pathways in cancer	hsa05200
PI3K-Akt signaling pathway	hsa04151
Progesterone-mediated oocyte maturation	hsa04914
Prostate cancer	hsa05215
Protein processing in endoplasmic reticulum	hsa04141

Structure Information

PDB ID	1QZ2
Resolution	3
Method	X-RAY DIFFRACTION
Chains	A
Molecule	FK506-binding protein 4
Model	View

Domain Information

ID	Location	Description
cd00075	37-185	HATPase_c
cl00075	37-185	HATPase_c superfamily
pfam00183	191-724	HSP90
cl20204	191-724	HSP90 superfamily
pfam02518	35-188	HATPase_c
smart00387	35-186	HATPase_c
pfam13589	33-153	HATPase_c_3
PTZ00272	14-724	PTZ00272
PRK05218	14-689	PRK05218
COG0326	14-688	HtpG
PTZ00130	17-693	PTZ00130
PRK14083	16-408	PRK14083

Ontology Information

HPRD ID	282
Molecular Class	Chaperone
Molecular Function	Oxidoreductase activity (GO:0016491)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report

CoReCG

Search results:

General Information

Evidence Information

Gene Details

mRNA Information

CDS Information

Protein Information

Post-translational Modification Information (Source : HPRD)

Enzyme Information

PPi Information

Pathway Information

Structure Information

Domain Information

Ontology Information

SNP Information

Drug Information

External Links

Important Information

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO