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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16502466 | 2006 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | ProteinChip Array, MS/MS | Up-regulation | - | One peak showing significantly high expression in the tumor was purified by reverse-phase chromatography and SDS-PAGE. The protein band of interest was passively eluted from the gel and identified as heat shock protein 10 (HSP 10) by tryptic digestion, peptide mapping, and MS/MS analysis. This tumor marker was further characterized by immunohistochemistry. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Heat Shock Proteins / Chaperonins |
| Description | This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3. |
| Chromosome | 2 |
| Location | 2q33.1 |
| Start | 197499997 |
| End | 197503463 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3467 |
| OMIM ID | 600141 |
| HGNC ID | HGNC:5269 |
| Unigene ID | Hs.1197 |
| Ensembl ID | ENSG00000115541 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_199440.1 |
|---|---|
| Exon | complement(164..278) | mRNA Sequence | Download Select all |
| Length | 965 |
CDS Information
| Location | join(441..443,1078..1242) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS63079.1 |
Protein Information
| Protein ID | NP_002148.1 |
|---|---|
| Protein Name | heat shock 10kDa protein 1 |
| Molecular Wt. (Da) | 10801 |
| Protein Sequence | Download Select all |
| Length | 102 |
| Uniprot ID | Q13547 |
| Ensembl Protein ID | ENSP00000362649 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 88;- |
| S | Phosphorylation | 51 |
| K | Acetylation | 86 |
| K | Acetylation | 56 |
| K | Acetylation | 99 |
| K | Acetylation | 70 |
| S | Phosphorylation | 64 |
| T | Phosphorylation | 79 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 217 | ALDH2 | 3 | NP_000681.2 | yeast 2-hybrid | 12387818 |
| 1400 | CRMP1 | 3913 | NP_001014809.1 | yeast 2-hybrid | 16169070 |
| 3329 | HSPD1 | 318 | NP_002147.2 | in vitro;in vivo;yeast 2-hybrid | 11 050 098 102 051 500 000 000 000 000 000 |
| 7088 | TLE1 | 2557 | NP_005068.2 | yeast 2-hybrid | 16169070 |
| 9094 | UNC119 | 4927 | NP_005139.1 | yeast 2-hybrid | 16169070 |
| 11161 | C14orf1 | 5201 | NP_009107.1 | yeast 2-hybrid | 16169070 |
| 11244 | ZHX1 | 10379 | NP_009153.3 | yeast 2-hybrid | 16169070 |
| 55791 | C1orf103 | 17975 | NP_060842.3 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00320 | 8-100 | cpn10 |
| cl09113 | 8-100 | cpn10 superfamily |
| smart00883 | 8-100 | Cpn10 |
| pfam00166 | 8-100 | Cpn10 |
| COG0234 | Aug-98 | GroES |
| PRK00364 | Aug-98 | groES |
| PTZ00414 | May-98 | PTZ00414 |
| PRK14533 | Aug-99 | groES |
Ontology Information
| HPRD ID | 4826 |
|---|---|
| Molecular Class | Heat shock protein |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.