Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ICAM1 | 3383 | Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor  | 19 | BB2; CD54; P3.58  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 9495363    | 1998 | Cell line : - Source : - Sample Type : CRC tumor and control tissue No. of Sample : 24 Stage : - | Immunohistochemistry, Northern Blotting. | Up-regulation | 2.1 | Densitometric analysis of specific signals demonstrated a 2.1-fold increase in ICAM-1 in colorectal cancers in comparison to normal colon samples. Over-expression of ICAM-1 might prevent cell cell disruption and, hence, tumor dissemination. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, Immunoglobulin superfamily / Immunoglobulin-like domain containing |
| Description | This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]   |
| Chromosome | 19 |
| Location | 19p13.3-p1 |
| Start | 10270841   |
| End | 10286615   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 15775   |
| OMIM ID | 147840    |
| HGNC ID | HGNC:5344    |
| Unigene ID | Hs.643447     |
| Ensembl ID | ENSG00000090339    |
| PharmGKB ID | PA29592    |
mRNA Information
| mRNA ID | NM_000201.2 |
|---|---|
| Exon | join(1..386,3925..4188,12641..12946,13193..13480, 13563..13817,13943..14188,14275..15775)   | mRNA Sequence |    Download   Select all |
| Length | 3249   |
CDS Information
| Location | join(320..386,3925..4188,12641..12946,13193..13480, 13563..13817,13943..14188,14275..14447) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS12231.1 |    
Protein Information
| Protein ID | NP_000192.2 |
|---|---|
| Protein Name | Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor |
| Molecular Wt. (Da) | 55215 |
| Protein Sequence |    Download   Select all |
| Length | 532   |
| Uniprot ID | P04040 |    
| Ensembl Protein ID | ENSP00000241052   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 521 |
| T | Phosphorylation | 530 |
| T | Phosphorylation | 527 |
| N | Glycosylation | 267 |
| N | Glycosylation | 145 |
| N | Glycosylation | 202 |
| S | Phosphorylation | 323 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2266 |    FGG |    621 |    NP_068656.2 |    in vitro;in vivo |    7822297    |
| 3559 |    IL2RA |    986 |    NP_000408.1 |    in vivo |    1976256    |
| 3684 |    ITGAM |    411 |    NP_000623.2 |    in vitro;in vivo |    110   731   029   488   691    |
| 6520 |    SLC3A2 |    1148 |    NP_001012679.1 |    in vivo |    12716892    |
| 7430 |    EZR |    475 |    NP_003370.2 |    in vitro;in vivo |    9705328    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| African trypanosomiasis |    hsa05143 |    
| AGE-RAGE signaling pathway in diabetic complications |    hsa04933 |    
| Cell adhesion molecules (CAMs) |    hsa04514 |    
| Epstein-Barr virus infection |    hsa05169 |    
| HTLV-I infection |    hsa05166 |    
| Influenza A |    hsa05164 |    
| Leukocyte transendothelial migration |    hsa04670 |    
| Malaria |    hsa05144 |    
| Natural killer cell mediated cytotoxicity |    hsa04650 |    
| NF-kappa B signaling pathway |    hsa04064 |    
| Rheumatoid arthritis |    hsa05323 |    
| Staphylococcus aureus infection |    hsa05150 |    
| TNF signaling pathway |    hsa04668 |    
| Viral myocarditis |    hsa05416 |    
Structure Information
| PDB ID | 1D3E |
|---|---|
| Resolution | - |
| Method | SOLUTION NMR |
| Chains | I   |
| Molecule | PROTEIN (INTERCELLULAR ADHESION MOLECULE-1)   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05755 | 113-207  | Ig2_ICAM-1_like |
| cl11960 | 113-207  | Ig superfamily |
| pfam03921 | 24-110  | ICAM_N |
| cl04329 | 24-110  | ICAM_N superfamily |
| cd07689 | 311-387  | Ig2_VCAM-1 |
| cl11960 | 311-387  | Ig superfamily |
| pfam13895 | 418-474  | Ig_2 |
| cl11960 | 418-474  | Ig superfamily |
| pfam13895 | 312-379  | Ig_2 |
| smart00410 | 404-474  | IG_like |
| smart00409 | 404-474  | IG |
| pfam07679 | 419-474  | I-set |
Ontology Information
| HPRD ID | 1043 |    
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P05362 | DB00108 | Natalizumab | BiotechDrug |
| P05362 | DB08818 | Hyaluronic acid | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
