Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ICAM1 3383 Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor  19BB2; CD54; P3.58 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
9495363   1998Cell line : -

Source : -

Sample Type : CRC tumor and control tissue

No. of Sample : 24

Stage : -

Immunohistochemistry, Northern Blotting.Up-regulation2.1 Densitometric analysis of specific signals demonstrated a 2.1-fold increase in ICAM-1 in colorectal cancers in comparison to normal colon samples.

Over-expression of ICAM-1 might prevent cell cell disruption and, hence, tumor dissemination.


Gene Details



19p13.3-p13.2

View Larger Image
   
Gene Type protein coding
Gene Family CD molecules, Immunoglobulin superfamily / Immunoglobulin-like domain containing
Description This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]  
Chromosome 19
Location 19p13.3-p1
Start 10270841  
End 10286615  
Strand +  
Gene Sequence

   Download   Select all

Length 15775  
OMIM ID 147840   
HGNC ID HGNC:5344   
Unigene ID Hs.643447    
Ensembl ID ENSG00000090339   
PharmGKB ID PA29592   

mRNA Information


mRNA ID NM_000201.2
Exon join(1..386,3925..4188,12641..12946,13193..13480, 13563..13817,13943..14188,14275..15775)  
mRNA Sequence

   Download   Select all

Length 3249  



CDS Information


   
Location join(320..386,3925..4188,12641..12946,13193..13480, 13563..13817,13943..14188,14275..14447)
CDS Sequence

   Download   Select all

CCDS ID CCDS12231.1



Protein Information


      
Protein IDNP_000192.2
Protein NameIntercellular adhesion molecule 1 (CD54), human rhinovirus receptor
Molecular Wt. (Da)55215
Protein Sequence

   Download   Select all

Length 532  
Uniprot IDP04040
Ensembl Protein ID ENSP00000241052  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation521
TPhosphorylation530
TPhosphorylation527
NGlycosylation267
NGlycosylation145
NGlycosylation202
SPhosphorylation323

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2266FGG621NP_068656.2in vitro;in vivo7822297   
3559IL2RA986NP_000408.1in vivo1976256   
3684ITGAM411NP_000623.2in vitro;in vivo110   731   029   488   691   
6520SLC3A21148NP_001012679.1in vivo12716892   
7430EZR475NP_003370.2in vitro;in vivo9705328   


Pathway Information


                                                                                    
Pathway Name Pathway ID
African trypanosomiasis hsa05143
AGE-RAGE signaling pathway in diabetic complications hsa04933
Cell adhesion molecules (CAMs) hsa04514
Epstein-Barr virus infection hsa05169
HTLV-I infection hsa05166
Influenza A hsa05164
Leukocyte transendothelial migration hsa04670
Malaria hsa05144
Natural killer cell mediated cytotoxicity hsa04650
NF-kappa B signaling pathway hsa04064
Rheumatoid arthritis hsa05323
Staphylococcus aureus infection hsa05150
TNF signaling pathway hsa04668
Viral myocarditis hsa05416


Structure Information


PDB ID1D3E
Resolution-
MethodSOLUTION NMR
Chains I  
Molecule PROTEIN (INTERCELLULAR ADHESION MOLECULE-1)  
Model View



Domain Information




ID Location Description
cd05755113-207  Ig2_ICAM-1_like
cl11960113-207  Ig superfamily
pfam0392124-110  ICAM_N
cl0432924-110  ICAM_N superfamily
cd07689311-387  Ig2_VCAM-1
cl11960311-387  Ig superfamily
pfam13895418-474  Ig_2
cl11960418-474  Ig superfamily
pfam13895312-379  Ig_2
smart00410404-474  IG_like
smart00409404-474  IG
pfam07679419-474  I-set


Ontology Information


   
HPRD ID1043
Molecular ClassAdhesion molecule
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P05362DB00108NatalizumabBiotechDrug
P05362DB08818Hyaluronic acidSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO