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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IRF8 | 3394 | interferon regulatory factor 8 | 16 | IRF-8, ICSBP |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19074829 | 2008 | Cell line : HCT116, DNMT1 Source : Medical College of Georgia Medical Center and Charite, Berlin. Sample Type : CRC tumor No. of Sample : - Stage : - | EMSA,Bisulfite genomic DNA sequencing,Chromatin immunoprecipitation assay | Methylation | - | Bisulfite genomic DNA sequencing revealed that the entire CpG island of the IRF8 promoter is methylated. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008] |
| Chromosome | 16 |
| Location | 16q24.1 |
| Start | 85932774 |
| End | 85956212 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 23439 |
| OMIM ID | 601565 |
| HGNC ID | HGNC:5358 |
| Unigene ID | Hs.137427 |
| Ensembl ID | ENSG00000140968 |
| PharmGKB ID | PA29606 |
mRNA Information
| mRNA ID | NM_002163.2 |
|---|---|
| Exon | join(1..56,3848..4022,9823..10006,12403..12491, 13964..14069,15306..15353,19250..19636,20942..21057, 21939..23439) | mRNA Sequence | Download Select all |
| Length | 2678 |
Protein Information
| Protein ID | NP_002154.1 |
|---|---|
| Protein Name | interferon regulatory factor 8 |
| Molecular Wt. (Da) | 48225 |
| Protein Sequence | Download Select all |
| Length | 426 |
| Uniprot ID | P23246 |
| Ensembl Protein ID | ENSP00000349748 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3659 | IRF1 | 961 | NP_002189.1 | in vitro;in vivo | 77 689 009 742 224 |
| 3660 | IRF2 | 962 | NP_002190.2 | in vitro;in vivo | 7768900 |
| 6688 | SPI1 | 1305 | NP_001074016.1 | in vitro | 10734131 |
| 7189 | TRAF6 | 3833 | NP_665802.1 | in vivo | 16484229 |
| 7709 | ZBTB17 | 4968 | NP_003434.2 | in vivo;yeast 2-hybrid | 12904288 |
| 64750 | SMURF2 | 6901 | NP_073576.1 | in vivo | 15761153 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Pertussis | hsa05133 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00103 | 7-114 | IRF |
| cl00096 | 7-114 | IRF superfamily |
| pfam10401 | 202-381 | IRF-3 |
| cl11061 | 202-381 | IRF-3 superfamily |
| pfam00605 | 9-115 | IRF |
| smart00348 | 9-115 | IRF |
| TIGR03363 | 308-422 | VI_chp_8 |
| cl19907 | 308-422 | ImpA-rel_N superfamily |
Ontology Information
| HPRD ID | 9165 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Apoptosis (GO:0006915) |
Drug Information
No matching records could be found.