Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ID1 | 3397 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 20 | dJ857M17.1.2, bHLHb24 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22698403 | 2012 | Cell line : - Source : University Health Network, Toronto. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | - | Up-regulation | - | ID1 and ID3 function together to govern colon cancer-initiating cell (CC-IC) self-renewal through cell-cycle restriction driven by the cell-cycle inhibitor p21. |
| 25623217 | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry | Up-regulation | - | Elevated Id1 levels were found in dysplasia and colon cancer arising in patients with inflammatory bowel disease. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 20 |
| Location | 20q11 |
| Start | 30193086 |
| End | 30194318 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 1233 |
| OMIM ID | 600349 |
| HGNC ID | HGNC:5360 |
| Unigene ID | Hs.504609 |
| Ensembl ID | ENSG00000125968 |
| PharmGKB ID | PA29608 |
Protein Information
| Protein ID | NP_851998.1 |
|---|---|
| Protein Name | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
| Molecular Wt. (Da) | 15455 |
| Protein Sequence | Download Select all |
| Length | 149 |
| Uniprot ID | Q8N474 |
| Ensembl Protein ID | ENSP00000220772 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 862 | RUNX1T1 | 590 | NP_783552.1 | in vivo | 11591653 |
| 4617 | MYF5 | 1168 | NP_005584.2 | in vitro;in vivo;yeast 2-hybrid | 9242638 |
| 4654 | MYOD1 | 1166 | NP_002469.2 | in vitro;in vivo;yeast 2-hybrid | 9242638 |
| 5710 | PSMD4 | 3386 | NP_002801.1 | in vitro;in vivo;yeast 2-hybrid | 9235903 |
| 6925 | TCF4 | 3780 | NP_001077431.1 | in vivo | 11591653 |
| 6929 | TCF3 | 918 | NP_003191.1 | in vivo | 11591653 |
| 8573 | CASK | 2164 | NP_003679.2 | in vitro;yeast 2-hybrid | 15694377 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hippo signaling pathway | hsa04390 |
| Rap1 signaling pathway | hsa04015 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| TGF-beta signaling pathway | hsa04350 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00083 | 68-109 | HLH |
| cl00081 | 68-109 | HLH superfamily |
| smart00353 | 68-109 | HLH |
| pfam00010 | 67-106 | HLH |
| COG1516 | 60-113 | FliS |
| cl00654 | 60-113 | FliS superfamily |
| PLN03217 | 33-114 | PLN03217 |
| cl14736 | 33-114 | PLN03217 superfamily |
Ontology Information
| HPRD ID | 16041 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.