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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ID3 | 3399 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 1 | HEIR-1, bHLHb25 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22698403 | 2012 | Cell line : - Source : University Health Network, Toronto. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | - | Up-regulation | - | ID1 and ID3 function together to govern colon cancer-initiating cell (CC-IC) self-renewal through cell-cycle restriction driven by the cell-cycle inhibitor p21. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011] |
| Chromosome | 1 |
| Location | 1p36.13-p3 |
| Start | 23884421 |
| End | 23886285 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1865 |
| OMIM ID | 600277 |
| HGNC ID | HGNC:5362 |
| Unigene ID | Hs.76884 |
| Ensembl ID | ENSG00000117318 |
| PharmGKB ID | PA29610 |
mRNA Information
| mRNA ID | NM_002167.4 |
|---|---|
| Exon | join(1..668,776..860,1380..1865) | mRNA Sequence | Download Select all |
| Length | 1252 |
Protein Information
| Protein ID | NP_002158.3 |
|---|---|
| Protein Name | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
| Molecular Wt. (Da) | 12868 |
| Protein Sequence | Download Select all |
| Length | 119 |
| Uniprot ID | Q6FHJ7 |
| Ensembl Protein ID | ENSP00000410715 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 5 |
| S | Phosphorylation | 5;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 862 | RUNX1T1 | 590 | NP_783552.1 | in vivo | 11591653 |
| 4617 | MYF5 | 1168 | NP_005584.2 | in vitro;in vivo;yeast 2-hybrid | 9242638 |
| 4654 | MYOD1 | 1166 | NP_002469.2 | in vivo;yeast 2-hybrid | 87 590 169 242 638 |
| 5079 | PAX5 | 1334 | NP_057953.1 | in vivo | 12054881 |
| 6720 | SREBF1 | 1701 | NP_001005291.1 | in vitro;in vivo | 10585876 |
| 6929 | TCF3 | 918 | NP_003191.1 | in vitro;in vivo;yeast 2-hybrid | 87 590 169 525 934 |
| 6938 | TCF12 | 2725 | NP_996919.1 | yeast 2-hybrid | 9242638 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| TGF-beta signaling pathway | hsa04350 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00083 | 42-85 | HLH |
| cl00081 | 42-85 | HLH superfamily |
| smart00353 | 42-86 | HLH |
| pfam00010 | 42-81 | HLH |
Ontology Information
| HPRD ID | 2887 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | RNA binding (GO:0003723) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.