Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ID4 | 3400 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 6 | bHLHb27 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15569977 | 2004 | Cell line : SW480, DLD1, LOVO Source : ATCC And Saint Johns Health Center (Santa Monica, CA) Sample Type : - No. of Sample : 131 colorectal tumors (13 adenomas, 92 primary CRCs, and 26 liver metastases) Stage : - | Methylation-specific PCR and bisulfite sequencing,real time RT-PCR | Methylation | - | ID4 gene is a potential tumor suppressor gene for which methylation status may play an important role in the CRC progression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner. [provided by RefSeq, Dec 2011] |
| Chromosome | 6 |
| Location | 6p22.3 |
| Start | 19837579 |
| End | 19842431 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4853 |
| OMIM ID | 600581 |
| HGNC ID | HGNC:5363 |
| Unigene ID | Hs.519601 |
| Ensembl ID | ENSG00000172201 |
| PharmGKB ID | PA29611 |
mRNA Information
| mRNA ID | NM_001546.3 |
|---|---|
| Exon | join(1..826,1215..1273,1841..4831) | mRNA Sequence | Download Select all |
| Length | 3891 |
Protein Information
| Protein ID | NP_001537.1 |
|---|---|
| Protein Name | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein |
| Molecular Wt. (Da) | 16491 |
| Protein Sequence | Download Select all |
| Length | 161 |
| Uniprot ID | Q07955 |
| Ensembl Protein ID | ENSP00000258962 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3399 | ID3 | 2608 | NP_002158.3 | in vivo;yeast 2-hybrid | 8759016 |
| 6925 | TCF4 | 3780 | NP_001077431.1 | yeast 2-hybrid | 11756408 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| TGF-beta signaling pathway | hsa04350 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00083 | 66-109 | HLH |
| cl00081 | 66-109 | HLH superfamily |
| smart00353 | 67-110 | HLH |
| pfam00010 | 66-105 | HLH |
Ontology Information
| HPRD ID | 9054 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | RNA binding (GO:0003723) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.