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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IDH1 | 3417 | isocitrate dehydrogenase 1 (NADP+), soluble | 2 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24887488 | 2014 | Cell line : - Source : Han Chinese patients Sample Type : CRC tumor No. of Sample : 305 Stage : - | real time RT-PCR,genome-wide association and sequencing study,direct sequencing | Down-regulation | - | Aberrant mRNA expression of IDH1, DNMT3A, and MYD88 gene might be actively involved in the development of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013] |
| Chromosome | 2 |
| Location | 2q34 |
| Start | 209100951 |
| End | 209120478 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 19528 |
| OMIM ID | 147700 |
| HGNC ID | HGNC:5382 |
| Unigene ID | Hs.593422 |
| Ensembl ID | ENSG00000138413 |
| PharmGKB ID | PA29630 |
mRNA Information
| mRNA ID | NM_005896.3 |
|---|---|
| Exon | join(1..205,1185..1258,3577..3714,6484..6775,9720..9825, 11540..11717,12999..13150,15141..15281,15911..16073, 17975..18917) | mRNA Sequence | Download Select all |
| Length | 2402 |
Protein Information
| Protein ID | NP_005887.2 |
|---|---|
| Protein Name | isocitrate dehydrogenase 1 (NADP+), soluble |
| Molecular Wt. (Da) | 46528 |
| Protein Sequence | Download Select all |
| Length | 414 |
| Uniprot ID | Q13247 |
| Ensembl Protein ID | ENSP00000244020 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 321 |
| K | Acetylation | 81 |
| K | Acetylation | 224 |
| T | Phosphorylation | 19 |
| T | Phosphorylation | 214 |
| Y | Phosphorylation | 219 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 11244 | ZHX1 | 10379 | NP_009153.3 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| 2-Oxocarboxylic acid metabolism | hsa01210 |
| Biosynthesis of amino acids | hsa01230 |
| Carbon metabolism | hsa01200 |
| Central carbon metabolism in cancer | hsa05230 |
| Citrate cycle (TCA cycle) | hsa00020 |
| Glutathione metabolism | hsa00480 |
| Metabolic pathways | hsa01100 |
| Peroxisome | hsa04146 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| PTZ00435 | 1-411 | PTZ00435 |
| cl00445 | 1-411 | Iso_dh superfamily |
| PRK08299 | 1-409 | PRK08299 |
| TIGR00127 | 3-411 | nadp_idh_euk |
| PLN03065 | 10-414 | PLN03065 |
| PLN00103 | 10-409 | PLN00103 |
| COG0538 | 10-406 | Icd |
| pfam00180 | 11-399 | Iso_dh |
| PLN00096 | 10-405 | PLN00096 |
| COG0473 | 16-377 | LeuB |
| TIGR00175 | 31-377 | mito_nad_idh |
| TIGR00169 | 172-377 | leuB |
| TIGR02088 | 36-381 | LEU3_arch |
| PRK14025 | 212-376 | PRK14025 |
| TIGR00183 | 212-405 | prok_nadp_idh |
| TIGR02924 | 211-376 | ICDH_alpha |
| PRK09222 | 211-290 | PRK09222 |
Ontology Information
| HPRD ID | 4264 |
|---|---|
| Molecular Class | Enzyme: Dehydrogenase |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.