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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IDH3A | 3419 | isocitrate dehydrogenase 3 (NAD+) alpha | 15 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24464829 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Two-dimensional gel electrophoresis and mass spectrometry, compared to whole-genome gene expression data, and evaluated by PANTHER classification system and Ingenuity Pathway Analysis (IPA). | Down-regulation | - | Down-regulation of IDH3A and PSMB3 were revealed as trisomy-associated alterations involved in regulating genome stability. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008] |
| Chromosome | 15 |
| Location | 15q25.1-q2 |
| Start | 78441698 |
| End | 78462884 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 21187 |
| OMIM ID | 601149 |
| HGNC ID | HGNC:5384 |
| Unigene ID | Hs.591110 |
| Ensembl ID | ENSG00000166411 |
| PharmGKB ID | PA29632 |
mRNA Information
| mRNA ID | XM_005254334.1 |
|---|---|
| Exon | join(1..69,5852..5914,7547..7801,8187..8270,10731..10845, 12220..12407,12873..13006,14146..14248,14355..14419, 15631..15715,16789..16941,19561..21181) | mRNA Sequence | Download Select all |
| Length | 2935 |
Protein Information
| Protein ID | XP_005254391.1 |
|---|---|
| Protein Name | isocitrate dehydrogenase 3 (NAD+) alpha |
| Molecular Wt. (Da) | 34375 |
| Protein Sequence | Download Select all |
| Length | 316 |
| Uniprot ID | O00141 |
| Ensembl Protein ID | ENSP00000237305 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 343 |
| T | Phosphorylation | 117 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3421 | IDH3G | 2100 | NP_004126.1 | in vivo | 10677231 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| 2-Oxocarboxylic acid metabolism | hsa01210 |
| Biosynthesis of amino acids | hsa01230 |
| Carbon metabolism | hsa01200 |
| Citrate cycle (TCA cycle) | hsa00020 |
| Metabolic pathways | hsa01100 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| TIGR00175 | 29-362 | mito_nad_idh |
| cl00445 | 29-362 | Iso_dh superfamily |
| PLN00118 | 8-359 | PLN00118 |
| COG0473 | 33-365 | LeuB |
| pfam00180 | 33-358 | Iso_dh |
| PRK08997 | 32-362 | PRK08997 |
| PLN00123 | 10-360 | PLN00123 |
| TIGR02088 | 34-358 | LEU3_arch |
| PRK14025 | 34-362 | PRK14025 |
| COG0538 | 37-363 | Icd |
| PRK00772 | 34-365 | PRK00772 |
| TIGR00183 | 37-358 | prok_nadp_idh |
| PRK07006 | 37-358 | PRK07006 |
| TIGR02089 | 34-362 | TTC |
| PRK03437 | 37-362 | PRK03437 |
| TIGR00169 | 34-362 | leuB |
| PRK06451 | 37-345 | PRK06451 |
| PRK08194 | 33-365 | PRK08194 |
| PRK07362 | 34-361 | PRK07362 |
| PLN02329 | 34-362 | PLN02329 |
| PLN03065 | 200-345 | PLN03065 |
| PLN00103 | 200-345 | PLN00103 |
| PRK08299 | 253-345 | PRK08299 |
| TIGR00127 | 200-345 | nadp_idh_euk |
| PTZ00435 | 200-345 | PTZ00435 |
| PRK09222 | 34-338 | PRK09222 |
| TIGR02924 | 34-362 | ICDH_alpha |
Ontology Information
| HPRD ID | 1646 |
|---|---|
| Molecular Class | Enzyme: Dehydrogenase |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.