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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11231887 | 2001 | Cell line : - Source : Ume hospital Sample Type : CRC tumor No. of Sample : 24 CRC , 4 normal tissue Stage : Duke stage B | In situ hybridization,RT-PCR,Northern blotting | Up-regulation | - | Expression of AQP8 is a marker of normal proliferating colonic epithelial cells and suggest these cells to be involved in fluid transport in the colon. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Ion channels / Aquaporins |
| Description | Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. [provided by RefSeq, Jul 2008] |
| Chromosome | 16 |
| Location | 16p12 |
| Start | 25228285 |
| End | 25240253 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 11969 |
| OMIM ID | 603750 |
| HGNC ID | HGNC:642 |
| Unigene ID | Hs.176658 |
| Ensembl ID | ENSG00000103375 |
| PharmGKB ID | PA24926 |
mRNA Information
| mRNA ID | XM_011545823.1 |
|---|---|
| Exon | join(1..142,280..530,10153..10287,11529..12017) | mRNA Sequence | Download Select all |
| Length | 1017 |
Protein Information
| Protein ID | XP_011544125.1 |
|---|---|
| Protein Name | aquaporin 8 |
| Molecular Wt. (Da) | 15872 |
| Protein Sequence | Download Select all |
| Length | 148 |
| Uniprot ID | Q99683 |
| Ensembl Protein ID | ENSP00000351908 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Bile secretion | hsa04976 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00333 | 38-231 | MIP |
| cl00200 | 38-231 | MIP superfamily |
| pfam00230 | 34-231 | MIP |
| TIGR00861 | 41-231 | MIP |
| COG0580 | 38-231 | GlpF |
| PLN00027 | 39-231 | PLN00027 |
| PLN00166 | 39-231 | PLN00166 |
| PLN00184 | 34-230 | PLN00184 |
| PLN00182 | 36-230 | PLN00182 |
| PLN00183 | 39-230 | PLN00183 |
| PRK05420 | 36-231 | PRK05420 |
| PLN00167 | 63-231 | PLN00167 |
| PTZ00016 | 9-219 | PTZ00016 |
| PLN00026 | 41-230 | PLN00026 |
| cd00333 | 39-129 | MIP |
| TIGR00861 | 34-125 | MIP |
| PRK09776 | 68-177 | PRK09776 |
Ontology Information
| HPRD ID | 2666 |
|---|---|
| Molecular Class | Water channel |
| Molecular Function | Metallopeptidase activity (GO:0008237) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.