Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IFNAR1 | 3454 | interferon (alpha, beta and omega) receptor 1 | 21 | IFRC |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21716316 | 2011 | Cell line : - Source : Hospitals located in the South East region of Norway. Sample Type : CRC tumor and normal tissues No. of Sample : 24 Stage : TNM Stage I-IV | - | Down-regulation | - | CLC and IFNAR1 were identified to be overall differentially expressed between early- and late-onset CRC, and are important in the development of early-onset CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interferons |
| Description | The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008] |
| Chromosome | 21 |
| Location | 21q22.1 |
| Start | 34696748 |
| End | 34732129 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 35382 |
| OMIM ID | 107450 |
| HGNC ID | HGNC:5432 |
| Unigene ID | Hs.529400 |
| Ensembl ID | ENSG00000142166 |
| PharmGKB ID | PA29670 |
mRNA Information
| mRNA ID | XM_005260964.1 |
|---|---|
| Exon | join(1..196,11082..11205,16557..16732,18826..18980, 19093..19234,20804..20918,24649..24848,24947..25101, 28316..28466,29196..29341,30874..35377) | mRNA Sequence | Download Select all |
| Length | 6064 |
Protein Information
| Protein ID | XP_005261021.1 |
|---|---|
| Protein Name | interferon (alpha, beta and omega) receptor 1 |
| Molecular Wt. (Da) | 55915 |
| Protein Sequence | Download Select all |
| Length | 488 |
| Uniprot ID | P04278 |
| Ensembl Protein ID | ENSP00000369816 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 466 |
| Y | Phosphorylation | 481 |
| S | Phosphorylation | 495 |
| S | Phosphorylation | 535 |
| S | Phosphorylation | 539 |
| T | Phosphorylation | 494 |
| N | Glycosylation | 58 |
| N | Glycosylation | 110 |
| N | Glycosylation | 313 |
| N | Glycosylation | 314 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3439 | IFNA1 | 974 | NP_076918.1 | in vitro | 7932753 |
| 3455 | IFNAR2 | 3850 | NP_997468.1 | in vitro | 15389589 |
| 3932 | LCK | 1080 | NP_005347.3 | in vitro;in vivo | 9403695 |
| 5788 | PTPRC | 1050 | NP_002829.2 | in vitro;in vivo | 9403695 |
| 6774 | STAT3 | 26 | NP_644805.1 | in vivo | 8626489 |
| 7535 | ZAP70 | 1495 | NP_001070.2 | in vitro;in vivo | 9403695 |
| 23291 | FBXW11 | 7294 | NP_036432.2 | in vitro;in vivo | 14532120 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Hepatitis B | hsa05161 |
| Hepatitis C | hsa05160 |
| Herpes simplex infection | hsa05168 |
| Influenza A | hsa05164 |
| Jak-STAT signaling pathway | hsa04630 |
| Measles | hsa05162 |
| Natural killer cell mediated cytotoxicity | hsa04650 |
| Osteoclast differentiation | hsa04380 |
| PI3K-Akt signaling pathway | hsa04151 |
| Toll-like receptor signaling pathway | hsa04620 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam09294 | 126-220 | Interfer-bind |
| cl21522 | 126-220 | FN3 superfamily |
| pfam09294 | 330-426 | Interfer-bind |
| cl21522 | 330-426 | FN3 superfamily |
| pfam01108 | 11-114 | Tissue_fac |
| cl21522 | 11-114 | FN3 superfamily |
| pfam01108 | 220-318 | Tissue_fac |
| cl21522 | 220-318 | FN3 superfamily |
Ontology Information
| HPRD ID | 2780 |
|---|---|
| Molecular Class | Cytokine receptor |
| Molecular Function | Protein binding (GO:0005515) |
| Biological Process | Signal transduction (GO:0007165); Cell communication (GO:0007154) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P17181 | DB00008 | Peginterferon alfa-2a | BiotechDrug |
| P17181 | DB00011 | Interferon alfa-n1 | BiotechDrug |
| P17181 | DB00018 | Interferon alfa-n3 | BiotechDrug |
| P17181 | DB00022 | Peginterferon alfa-2b | BiotechDrug |
| P17181 | DB00034 | Interferon Alfa-2a, Recombinant | BiotechDrug |
| P17181 | DB00060 | Interferon beta-1a | BiotechDrug |
| P17181 | DB00068 | Interferon beta-1b | BiotechDrug |
| P17181 | DB00069 | Interferon alfacon-1 | BiotechDrug |
| P17181 | DB00105 | Interferon Alfa-2b, Recombinant | BiotechDrug |
| P17181 | DB05258 | Natural alpha interferon | BiotechDrug |