Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MACC1 | 346389 | metastasis associated in colon cancer 1 | 7 | 7A5, SH3BP4L |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23665971 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : 64 Stage : TNM Stage Iv | real time RT-PCR | Unknown | - | MACC1, a new easily detectable biomarker in cancer, is an independent prognostic factor of recurrence after liver resection of colorectal cancer metastasis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]). |
| Chromosome | 7 |
| Location | 7p15.3 |
| Start | 20134655 |
| End | 20217390 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 82736 |
| OMIM ID | 612646 |
| HGNC ID | HGNC:30215 |
| Unigene ID | Hs.598388 |
| Ensembl ID | ENSG00000183742 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_182762.3 |
|---|---|
| Exon | join(1..92,46613..46677,52992..53135,55521..55643, 57146..59187,63010..63198,76233..82736) | mRNA Sequence | Download Select all |
| Length | 9167 |
CDS Information
| Location | join(55529..55643,57146..59187,63010..63198,76233..76445) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS5369.1 |
Protein Information
| Protein ID | NP_877439.3 |
|---|---|
| Protein Name | metastasis associated in colon cancer 1 |
| Molecular Wt. (Da) | 96508 |
| Protein Sequence | Download Select all |
| Length | 852 |
| Uniprot ID | P51884 |
| Ensembl Protein ID | ENSP00000266718 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01670 | 743-818 | Death |
| cl14633 | 743-818 | DD superfamily |
| COG2759 | 686-764 | MIS1 |
| cl21455 | 686-764 | P-loop_NTPase superfamily |
Ontology Information
| HPRD ID | 5161 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.