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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15817610 | 2005 | Cell line : - Source : Kaiser Permanente Medical Care Program of Northern California (KPMCP), the state of Utah, and the Twin City metropolitan area of Minnesota. Sample Type : Population based case-control study No. of Sample : Colon cancer (1556 cases and 1948 controls) and rectal cancer (777 cases and 988 controls) Stage : - | Genotyping | Mutation | - | ApoE genotypes that do not include the e3 allele, the same genotypes that are associated with increased risk of coronary heart disease, may influence development of colon cancer among those who are older at diagnosis.
|
| 22799385 | 2012 | Cell line : - Source : Department of Gastrointestinal Surgery, Guangdong Provincial People Hospital. Sample Type : CRC tumor and Normal tissue No. of Sample : 13 Stage : - | 2-D Gelelectrophoresis and MALDI-TOF mass spectrometry. | Up-regulation | - | This Gene differentially expressed and analysed by 2-D Gel Electrophoresis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Apolipoproteins |
| Description | Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008] |
| Chromosome | 19 |
| Location | 19q13.2 |
| Start | 44905749 |
| End | 44909395 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3647 |
| OMIM ID | 107741 |
| HGNC ID | HGNC:613 |
| Unigene ID | Hs.654439 |
| Ensembl ID | ENSG00000130203 |
| PharmGKB ID | PA55 |
mRNA Information
| mRNA ID | NM_001302688.1 |
|---|---|
| Exon | join(1..175,854..919,2012..2204,2785..3647) | mRNA Sequence | Download Select all |
| Length | 1223 |
CDS Information
| Location | join(121..175,854..919,2012..2204,2785..3502) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_000032.1 |
|---|---|
| Protein Name | Apolipoprotein E |
| Molecular Wt. (Da) | 34237 |
| Protein Sequence | Download Select all |
| Length | 317 |
| Uniprot ID | Q99541 |
| Ensembl Protein ID | ENSP00000276914 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Glycosylation | 212 |
| L | Proteolytic Cleavage | 286 |
| M | Proteolytic Cleavage | 290 |
| K | Glycation | 93 |
| S | Phosphorylation | 147 |
| S | Phosphorylation | 241 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2 | A2M | 72 | NP_000005.2 | in vitro;in vivo | 9831625 |
| 213 | ALB | 62 | NP_000468.1 | in vitro | 8063017 |
| 351 | APP | 100 | NP_000475.1 | in vitro | 10559559 |
| 1270 | CNTF | 347 | NP_000605.1 | in vitro | 9236223 |
| 4137 | MAPT | 1142 | NP_001116538.1 | in vitro;in vivo | 914 740 875 666 529 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alzheimer's disease | hsa05010 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01442 | 104-299 | Apolipoprotein |
| pfam01442 | 61-186 | Apolipoprotein |
| pfam12128 | 65-278 | DUF3584 |
Ontology Information
| HPRD ID | 57 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Lipid transporter activity (GO:0005319) |
| Biological Process | Lipid storage (GO:0019915); Lipid transport (GO:0006869) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P02649 | DB00062 | Human Serum Albumin | BiotechDrug |
| P02649 | DB00064 | Serum albumin iodonated | BiotechDrug |