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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IGF2R | 3482 | Insulin-like growth factor 2 receptor | 6 | MPR1; MPRI; CD222; CIMPR; M6P-R |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22997602 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Mutation | - | Mutationm due to inactivation of DNA mismatch repair syste,results MSI |
| 22377707 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Polymorhpism | - | IGF2R c.901 C>G may increase cancer risk. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules |
| Description | This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq, Apr 2013] |
| Chromosome | 6 |
| Location | 6q26 |
| Start | 159969099 |
| End | 160106551 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 137453 |
| OMIM ID | 147280 |
| HGNC ID | HGNC:5467 |
| Unigene ID | Hs.487062 |
| Ensembl ID | ENSG00000197081 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_000876.2 |
|---|---|
| Exon | join(1..297,22086..22225,39912..40036,41589..41687, 55474..55606,58087..58216,60452..60557,63453..63615, 63844..64009,65321..65424,71462..71626,74050..74190, 75416..75559,76647..76784,77400..77547,78061..78238, 78694..78809,79277..79445,81375..81554,87326..87427, 88925..89026,89808..90000,91449..91619,92405..92548, 92655..92830,93434..93521,94317..94532,95303..95433, 95706..95803,99151..99287,100770..100960,102812..102938, 103667..103786,104115..104371,104659..104877, 106749..106898,109103..109264,110482..110689, 111031..111177,114852..115086,115897..116033, 118935..119049,120009..120155,120818..121005, 127341..127527,133421..133573,134648..134717, 135576..137453) | mRNA Sequence | Download Select all |
| Length | 9093 |
CDS Information
| Location | join(149..297,22086..22225,39912..40036,41589..41687, 55474..55606,58087..58216,60452..60557,63453..63615, 63844..64009,65321..65424,71462..71626,74050..74190, 75416..75559,76647..76784,77400..77547,78061..78238, 78694..78809,79277..79445,81375..81554,87326..87427, 88925..89026,89808..90000,91449..91619,92405..92548, 92655..92830,93434..93521,94317..94532,95303..95433, |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS5273.1 |
Protein Information
| Protein ID | NP_000867.2 |
|---|---|
| Protein Name | Insulin-like growth factor 2 receptor |
| Molecular Wt. (Da) | 270238 |
| Protein Sequence | Download Select all |
| Length | 2491 |
| Uniprot ID | P32239 |
| Ensembl Protein ID | ENSP00000335544 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 2484;- |
| S | Phosphorylation | 2400 |
| S | Phosphorylation | 2409 |
| S | Phosphorylation | 2479 |
| S | Phosphorylation | 2401 |
| K | Acetylation | 2352 |
| N | Glycosylation | 957 |
| T | Phosphorylation | 1107 |
| T | Phosphorylation | 1111 |
| T | Phosphorylation | 1828 |
| S | Phosphorylation | 1831 |
| T | Phosphorylation | 2087 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3002 | GZMB | 476 | NP_004122.2 | in vitro | 11081635 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Endocytosis | hsa04144 |
| Lysosome | hsa04142 |
Structure Information
| PDB ID | 1E6F |
|---|---|
| Resolution | 1.75 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B |
| Molecule | CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00062 | 1897-1942 | FN2 |
| cl09951 | 1897-1942 | FN2 superfamily |
| pfam00878 | 423-573 | CIMR |
| cl03002 | 423-573 | CIMR superfamily |
| pfam00878 | 1322-1462 | CIMR |
| cl03002 | 1322-1462 | CIMR superfamily |
| pfam00878 | 1031-1178 | CIMR |
| cl03002 | 1031-1178 | CIMR superfamily |
| pfam00878 | 723-875 | CIMR |
| cl03002 | 723-875 | CIMR superfamily |
| pfam00878 | 1465-1599 | CIMR |
| cl03002 | 1465-1599 | CIMR superfamily |
| smart00059 | 1899-1942 | FN2 |
| pfam00040 | 1903-1942 | fn2 |
| pfam00878 | 1608-1731 | CIMR |
| cl03002 | 1608-1731 | CIMR superfamily |
| pfam00878 | 1759-1894 | CIMR |
| cl03002 | 1759-1894 | CIMR superfamily |
| pfam00878 | 128-265 | CIMR |
| cl03002 | 128-265 | CIMR superfamily |
| pfam00878 | 1949-2083 | CIMR |
| cl03002 | 1949-2083 | CIMR superfamily |
| pfam00878 | 2238-2279 | CIMR |
| cl03002 | 2238-2279 | CIMR superfamily |
| pfam00878 | 2089-2150 | CIMR |
| cl03002 | 2089-2150 | CIMR superfamily |
| pfam09451 | 475-621 | ATG27 |
| pfam02157 | 323-477 | Man-6-P_recep |
| pfam09451 | 1992-2147 | ATG27 |
| pfam09451 | 358-485 | ATG27 |
Ontology Information
| HPRD ID | 451 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Kinase binding (GO:0019900) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P11717 | DB01277 | Mecasermin | BiotechDrug |