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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IGFBP1 | 3484 | insulin-like growth factor binding protein 1 | 7 | IGF-BP25, AFBP, hIGFBP-1, PP12 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20501760 | 2013 | Cell line : - Source : Caucasians, Japanese, and Native Hawaiians in Hawaii. Sample Type : Population based case-control study No. of Sample : 554 CRC cases and 786 controls Stage : - | Meta Analysis | Down-regulation | - | Results provide evidence for an association of insulin and IGFBP-1 levels with colorectal adenoma.
|
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008] |
| Chromosome | 7 |
| Location | 7p12.3 |
| Start | 45927959 |
| End | 45933267 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 5309 |
| OMIM ID | 146730 |
| HGNC ID | HGNC:5469 |
| Unigene ID | Hs.642938 |
| Ensembl ID | ENSG00000146678 |
| PharmGKB ID | PA29703 |
mRNA Information
| mRNA ID | NM_000596.2 |
|---|---|
| Exon | join(1..642,2189..2358,3573..3701,4601..5309) | mRNA Sequence | Download Select all |
| Length | 1660 |
Protein Information
| Protein ID | NP_000587.1 |
|---|---|
| Protein Name | insulin-like growth factor binding protein 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 259 |
| Uniprot ID | P29353 |
| Ensembl Protein ID | ENSP00000357430 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 108 |
| S | Phosphorylation | 126 |
| S | Phosphorylation | 144 |
| S | Phosphorylation | 194 |
| S | Phosphorylation | 108 |
| S | Phosphorylation | 126 |
| S | Phosphorylation | 144 |
| S | Phosphorylation | 176 |
| H | Proteolytic Cleavage | 165 |
| H | Proteolytic Cleavage | 165 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00191 | 175-251 | TY |
| cl00150 | 175-251 | TY superfamily |
| smart00121 | 28-105 | IB |
| cl02472 | 28-105 | IGFBP superfamily |
| pfam00086 | 176-251 | Thyroglobulin_1 |
| pfam00219 | 30-84 | IGFBP |
| smart00211 | 203-251 | TY |
Ontology Information
| HPRD ID | 2838 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.