CoReCG

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General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
IGFBP3	3486	insulin-like growth factor binding protein 3	7	IBP3, BP-53

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
25127039	2014	Cell line : - Source : Hospital 12 de Octubre, Madrid; Hospital Clinic, Barcelona; Hospital Cl?nico Universitario, Zaragoza; Hospital Cristal-Pinor, Complexo Hospitalario de Ourense; Parc de Salut Mar, Barcelona; Hospital Donostia, CIBERehd, University of Country Basque, San Sebastian; Hospital General Universitario de Alicante; Hospital General de Granollers; Hospital General de Vic; Hospital General Universitario de Guadalajara and Fundaci?n para la Formaci?n e Investigaci?n Sanitarias Murcia; Hospital General Universitario de Valencia. Sample Type : CRC tumor and normal tissue No. of Sample : :425 CRC patients Stage : TNM Stage II,III	Bisulfite pyrosequencing	Hypermethylation	-	IGFBP3 hypermethylation may serve as an independent prognostic and predictive biomarker in stage II and III CRC patients.

Gene Details

Chromosome 7 - NC_000007.14 (45912245..45921272, complement)
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Gene Type	protein coding
Gene Family
Description	This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Chromosome	7
Location	7p12.3
Start	45912245
End	45921272
Strand	-
Gene Sequence	>gi\|568815591:c45921272-45912245 Homo sapiens chromosome 7, GRCh38.p2 Primary Assembly AGATGCGAGCACTGCGGCTGGGCGCTGAGGATCAGCCGCTTCCTGCCTGGATTCCACAGCTTCGCGCCGT GTACTGTCGCCCCATCCCTGCGCGCCCAGCCTGCCAAGCAGCGTGCCCCGGTTGCAGGCGTCATGCAGCG GGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGCTGGTGCTGCTCCGCGGGCCGCCGGTGGCGCGG GCTGGCGCGAGCTCGGCGGGCTTGGGTCCCGTGGTGCGCTGCGAGCCGTGCGACGCGCGTGCACTGGCCC AGTGCGCGCCTCCGCCCGCCGTGTGCGCGGAGCTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTG CGCACTGAGCGAGGGCCAGCCGTGCGGCATCTACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCG TCGCCCGACGAGGCGCGACCGCTGCAGGCGCTGCTGGACGGCCGCGGGCTCTGCGTCAACGCTAGTGCCG TCAGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGTGAGCCGCCCGCGCCAGGTGCGCT GCGTGCAGCACCCGGCGCACTGGCGCCGAAGGGCCTGGGGGTTGCTGGGTGCCGCTGCGGGAGACTCCGC TTTTCTTCTCACTGGAGATAATATGTGGGGAAACTGAAGGCGCTCCGGGAAAGGTGAAGGCGGTCGCCGG AGGGACCCTCCCCAGCCGGCCCTCTACTTGCTCGATTCTCTAAGTGCAGAGTACTTGTAAATTGCAAAGC GCTTTCAGTGAAAATGGGTTAAAGGTTTCCGGAGCTGAGGGGAGCGGTACCGATGTTTAGCTGTTGGAAA GATCCTGGACACAGGAGATTCTCCTCGCCCCGCACGGGGGTGCACACGGACTGCAATCCCAGGGATGCTT GGGGATGGGGGGGATATAGGCGGATTTGGACCAAGGAAGGTGGGCAGGCACGTTGTAGGAAATAGTACCT CTCTTTTAAAATACTGACTTTGCACAGCCTTTTGGTTTGCAAAGCAATGTCTAGTCCCGGTATGTCCAAA AACAAGTAAAGTGGATTCGGGTTTTGATATCTTCTGCGGTTGGAAAACCTGAAGCTGAAAAAGAAGTAAC TTCTTAAGGTTACCCAGCGGCCACAACAGAGTGTAGGTTTGAACTCCGCGTGCCACTTTCAGTACCATAC CATTCTTACAACTCGGGCCACCCCTGCACCTGCGCCGACCTCAAACAAACTTCCAGGTGCGTGGTGGGTG CGGGCAATGTGGACTAAGTCAATTTCAATGACACGGAAGGGAATTGGAATCAGTCCTAGGGCTGTCTCCC TTCTTAATCTGAAATGGGGGGGGGAATGAGATGTTGTTAAGGGGAGCCCCAGAAGAGGAAAAATGCAAAC ATTTGGCAGAGTTACCCTCTTGGCTTAGCCACTATCAGTATCAGGCAGACAGCGACTCTGGTAAGGGCAT CACATTGTTCCCTTAAAAAAAGGAGCGGGGGTTGTTTAAATGGATTTGGCAGCTGTTCTTTCAAGCATTC TTAGCCAGCCTCACCTAGTTATATGAGAAATAAAGTTCCTGCCTTGCACAGCTGAAGGCTGGGAGAATTC TCCCCATCCTAATTCCCCCAACTCCCCAACGATCACGTTGGACAGATGTCACTGGGCAGGCCCCCATCTA GGGCTAGCAGGATGAACAGTCCCTTTATAATTTATGTAGCTGTAGAGTTCCACGCCCGGGTGAAGTTATT TTCTGGCTCGGCAAGGCTGGCTCTGTTCACCCCTGAGAAATGCTGGATTCATGGAAAGGCAAGATGCCTG AAACATACACTGGCTCTGGTCAGCTGTTAAAGCTGCTGGAGGCATTTGTCTCTCGGGGCAAAGTTATGTC ATTTGCCAAGTGTCGTACATTATTGTGCATTTTGGGGTATTCAAAAAGTGATCTTAGAAATACTGATACA CATCGTCATTCTTGGGCTTTAGCAATCATCATGATTACCACCTTAGTAGCACTGTAGTATAGGTTGATGT GAGTTATAAGATTATAAAAAGATCTAAGTGACTTCTAGAATCTATTTGACAAAAAAAGGTAAATTTTCGA CAGTCAAAAGTCACAATTATCTGTTGCTTAAATAGAACTGTTTTGTCTTCATGCCCTAGTCTGCAGCCCA GGCATTAAGAAGAAACCAAGGAAATTTAAGAAATTACTCAAGGTTCTTAGAAAAGAAGTATAAATACGTT TATTTACATGTTCTTAGAGTATTTACATTCTTAGTATCTCTTTTATCTCAGTATTTCCTTGAAAAAGAAA GCAAGCTAAGATTAAAAGAAATTGAAACCAAATCCTCGCAGGTAGGGACCTCCTCTGTGAGGCTCTGTGC TGGACCCTGGGAATGTGTGCTTCCCAAGGTATGAAACCCCTTGGGGAACTTTACAGCAGGACCTCAGTGA GCTGTTTGGCAGGTGAGGAAACTAAGACCCAGAGAGGAGAGGGACTTTCCTAAGGCCCTGGTGAGTGACC TGCCAGTAGCCACTTCCAGGGGAGAGCAGAGCATCTGCAGCCAAATCATTGCAGCCCCAGGTAGCTTTCT AGAATAGACTGTGGACCAGATGGGCCACCTGAGCTCCCTGCTAGGGTTACACATTATAGCCCTGTTTGTT GTAGTAGAGAAATTTCATGACTCTCAATTGTGGACTTAAGCCGATGCCTCCAGACCTTGGCATGGTCCAC AGGCCCTGGGAGCATGGGCTCTGAATGTAGCCTTTGATCCCCATAGCGGTCTTACAGCCCCTCCAAGTTC ATTCTGAAGAAGGAATGGAGTGAGAATCCTGGCTGCAGATCCAGTCTTGAATTTAGTCATATACTTAAAA TTCCAATTCAACTGTTAACATTCCAGCATCCATTTTAAGCATCAGACTTTCTTCATTTAGCACTTTTTAT TATAAAAGGGAGATCTGCTGGAGGGGGATTTCTCCTACCCCACCCCCACCCAGGGAAGGAAAAGCTCTTT GGCACTTAGAAGTCTGAGCCGTGAGTGGGACTTTGGCATTGTCTGCATCCATGTGCTGCTGTGTTCACCC GGGGTGAAAAGGACTCACTTAGGCAGGCACCAGCAAGATGCACAGGGTCTGTGTAGACCTTGAGTTTTAG AGATGTAACGGGGACCTAGAAAACAAGCCACCAACATGCTTGCATGATTCTGAGCCCCTGAGGCAAAACG CTTTGCAGGTAATAATTCAGTTTTCCCATCTGAGCTGGACACCAAGCTCTTATAAGCGTGTTTACCTGGT AGCATTGAGGACGGTACTGGTCAACCTTGGAATTCCCATAAGGGCTTGTTACAACTCAGACTGCTGCCGC CACTCCAGCGTTTCCGGAGTGGAGAATGTGCATTTCTTCCAAGTCCCCGGGCTGCCGCTGCTCCCGCGGG TGGGAGGACCACACTTGGAGTTGACTGCAAAATTTCTGAGCCGGCGCTGCAGCAGCCTCCCGTGGCTCAG GTCTGCCCCCTGCCGGTGGAAGATGAAGCATACTGCCTTCACCTACTGAGGGGCACTGAAGCGTTTGTCT GCCTTCTTTAGTTGCAGCTACTTAGGAAGAGCACCTGTCAGATTGACTTTCAAACAGATAACTTCTTGAG GTAGAGCAACCACCATGTAGTGAGTAGTATGATGGAATAATACTTCATCGAGGTATTTTAAAAAAAAAAA CTCACTTGGATTGCCAACTAATATTGTCATTTACATGTGACCTGGTTGCAACGTTAAGATTTTTAAAAGA CTGTGATAGATATTGATGACTCTCATGTGTTTGTCTCTCTTGGGCGTTTTAAGGAAATGCTAGTGAGTCG GAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTGTCTGATCCCA AGTTCCACCCCCTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCTAAAGACAGCCAGCGCTACAA AGTTGACTACGAGTCTCAGAGCACAGATACCCAGAACTTCTCCTCCGAGTCCAAGCGGGAGACAGAATAT GTGAGAGCTTTTCCTCTTGTTAAAGGAGGAGGGCAAGACCTGCCAAGCCTGGGTACTCAGAGCCTCTTGA GGGCAATTCTTACTCAACAAACCCCAGCGCCTGGCTGATGGGTGGGCAACCCCTAGCCCCTCTGTGCCCT ACCTCTCTCCTCTCCTTACATAAAGAATATTGACCCTTTTGGAGAATCTTATGAGGATCAAGCTGAAATA ACACTCTTAAAAGCATATGGGATGTCATAAAGACCTCTGCAGATAATGAAAAATATTCTCATAAAGATAG TTTTATTTACTTCATCCTCTATGCTTGTTGACCTGCTATTGGTTCCATACCAGCTTCTGTGCCTTACTCT GGGAAGAGCAAAAAGGAGACAGGGAGTGATGGTTAGCTTATTCGGGGGACTTTCGTGCTACATCAGACAT AAGGTATCTGAGGAGCAAATTACAGGTCCCACTTTTGGTAGTTGTGCAGCATCGTAAGATTTTTAAAGCA CACATTCTAGAGTAAAAACTGTGACTCTGTTGCTCTGGTCCTTCCTGATCCCCAGGGTCCCTGCCGTAGA GAAATGGAAGACACACTGAATCACCTGAAGTTCCTCAATGTGCTGAGTCCCAGGGGTGTACACATTCCCA ACTGTGACAAGAAGGGATTTTATAAGAAAAAGCAGGTGAGTGAGGTCCTCAGTGTGTTTTCTTCCTCTTC TGTTGACACAGAGGAGAAACCCATCTCACCAGCCCCCAGGCTCTTCTGGCCATAGCTCTAACTCTGAGCC TGTGCAGCACCAGTGCCCAGGACTTGGTGCCAGTCTCAGGAGGTCAGACCAAGGGCTGCTTTGACTTGTT GCTCTGAGTGCTGCTATATTGGCCATAATCCTCAACCCTAGTGCCTTTCCACCACCCGCTTCCCACTCCT GTCCTTTCAATGGTTCACCCACAGGGCGGACAAGATGCTGCCCAGTGGCACCCTTTATAAACTGCAAGTG GACATGTTAACACATTTGTTAATGCTGCGTCAGGGAGTGACATTTCAAACAACTATTATAGTCAGTTTCC AAGAAGTGTGACATGAGGTCATACCACAAAAAGCTTACCCTGAAATCCCACAATCGTCCCCTTTCCTACT GATGCCTTCCCGATAGTGAGCAGGTTGCAATATTAAGATTTTGAAAAGGCTGTTGCTAGATGTTGGTGAC TCGTGTGTCTCTGTCTCCCTTGGGCTTTTCAAGGAAATGCTAGTGAGTGGGGGGATGACTGCAGCATGGC CAGCTTGGAGAGCCCAGCCATCCCCAGCACATACCAGGTGTCTGTCTTGGCGTGGAGGGGATGGAACTTG AAATCAGACACTCGGTCCATGCTGGGGATGGCCAGTCTCTCCAAACTGGCCATGTGGTCTTCCTCCGACT CACTGGCATTTCCCTAGAAAGTCCAAGTGAGAAGAAGGCATGAGAGTCATCAACATCAAACAACAGTCTT TTCAAAATCTTTATATTGCAACATAGTCCCATTCCTGGAAAAGGAATGGAGTGAGAATCCTGGCTACACA TCAGCCCCAAATGTAGTCATATGCCTAAAATCCCAATTAACCTGAAAATGATCAAACAAATTTAAGATAT AGTAATATTAAGCTGTAATAAATATGCTTCTATAGGCTTTGTGTTATGTGATGGCACTATTTCAATTGGC TTTCTAATTGGACAATTGATACTATGCTATCTACAGAATTGGCCTTTGGAGACCTAAGTGAGCCACAGTG GCCTCAGGGTGACCATATACTAGGATTCATAGTAGTGGCCACAGTCAGAAAGCCTAAGCTTTCCTCCATT GCCATTGCTCGTTTATACCCACGTTTTCTGTCAAAGTCATATTCATTCAACAAAGTCATACTGAGAAGGT GTCATGTGAGGCTGGATGTGGGCTCCAAAGTCATAGCTGTGACATTCGCAGGCAGCGGGGATGTTCTCAG TCCCACATTTGGCAGAGAAGTCAGTCAAGAGGTTCTACAAGGGCTGGTGTCCACCTTATACTCCTAGAAA CACAAAACTGCCCCCACCCCCGCTTTCTTGGAGCAGGAAGTTACACCCACACGCATGCACAGGCGCACAC TCAGCGGGCCTAGGCACGCATGGCTCTTGTGTTGCCTTAGCTGAAATTTCTGTTGTGCTTTCTCAGCATA GCAGAGTCACGCTGGCAAACCATCATGCGCCCTGGCCACCGACCTGACACCAGACCCAGGAGCATTCACT TCTCTGTCTTCTGTTTCTCTCCCACAGTGTCGCCCTTCCAAAGGCAGGAAGCGGGGCTTCTGCTGGTGTG TGGATAAGTATGGGCAGCCTCTCCCAGGCTACACCACCAAGGGGAAGGAGGACGTGCACTGCTACAGCAT GCAGAGCAAGTAGACGCCTGCCGCAAGGGTGAGTACTCAGGAGGGGCAGCCTGGGGCTCCAGGGCCTCAC TGTCCTTGGACCAGCCTCAGGGGCTGGGCGTGGCCACTGGCCCTTCCCCAGGCTTACAGACCCAGGAGCT GCAGCTCAGGGCCAGAAAGAGCAAAGCAAATAGGACAGAGCCCTCAGAAGGGTGCAGGGAGAGGGAGACC CCATCAACCCAACCAAACAAGTGTGGGGAAGGAGGCCGGCCAGTGCACCTCAGGGACACTCTGCTTTATC TCAGATACCTCACAGCACCTAAGCTATCATTCATCCACACACAAAGTGAAGATTTTCAAAGTTAGGCTTT ACCCGTGAGGTCTGGAGGTCCATTTATCTTCACAGAGAAACCGTTTTAATCCGCAAGAACCTGCTAAAGA TACATGTTTCTAAATTAAAGATGTGAATGTGAGACAGCTGAAATAGCTCAGTTGGGAGAGCATCAGTTTG AAGATGCAGCTTTTTTTTTCTGTAAAATATATAATGAATATTCTGTTAGTCTGTGGCTAATATAATTTTA ATAAAGTTAATTTAAATCTGATAGAAAAATGAAATTTTAAACGATAATTTTAGAGAATGCTATTATATCC AGTCTTCTTTTTTCTTTTAATAAATGAGGGAACTATTGGGGGAAAGGAATAAATACATTTTCTTTCATTT TATTAAGACAAATTTAGTAAGCAGAAGAAATTTGCATGTTTAGTTATAAGGGTTTCTTTTTTCCTTACAA GTTGGAAAAAATAATTCTAATTTAAGGGTAACTCTTTGACAATGAACACTGTGAGCAGCATCTGGTACTC GTTGCTTTGTTTGAAAACATGAGTTGAGACCCCAGCCCTGCACTTGCAGGCCTAGTGCCATTAGCCTGCA GGCTGTGCTGGATATCTCAGGGCAAGAGTCGAGCCCTTTTGATTTTGGGGGGATTATTTCAATATATTTC TTTTTCTTTTTGTTTTAGTTAATGTGGAGCTCAAATATGCCTTATTTTGCACAAAAGACTGCCAAGGACA TGACCAGCAGCTGGCTACAGCCTCGATTTATATTTCTGTTTGTGGTGAACTGATTTTTTTTAAACCAAAG TTTAGAAAGAGGTTTTTGAAATGCCTATGGTTTCTTTGAATGGTAAACTTGAGCATCTTTTCACTTTCCA GTAGTCAGCAAAGAGCAGTTTGAATTTTCTTGTCGCTTCCTATCAAAATATTCAGAGACTCGAGCACAGC ACCCAGACTTCATGCGCCCGTGGAATGCTCACCACATGTTGGTCGAAGCGGCCGACCACTGACTTTGTGA CTTAGGCGGCTGTGTTGCCTATGTAGAGAACACGCTTCACCCCCACTCCCCGTACAGTGCGCACAGGCTT TATCGAGAATAGGAAAACCTTTAAACCCCGGTCATCCGGACATCCCAACGCATGCTCCTGGAGCTCACAG CCTTCTGTGGTGTCATTTCTGAAACAAGGGCGTGGATCCCTCAACCAAGAAGAATGTTTATGTCTTCAAG TGACCTGTACTGCTTGGGGACTATTGGAGAAAATAAGGTGGAGTCCTACTTGTTTAAAAAATATGTATCT AAGAATGTTCTAGGGCACTCTGGGAACCTATAAAGGCAGGTATTTCGGGCCCTCCTCTTCAGGAATCTTC CTGAAGACATGGCCCAGTCGAAGGCCCAGGATGGCTTTTGCTGCGGCCCCGTGGGGTAGGAGGGACAGAG AGACAGGGAGAGTCAGCCTCCACATTCAGAGGCATCACAAGTAATGGCACAATTCTTCGGATGACTGCAG AAAATAGTGTTTTGTAGTTCAACAACTCAAGACGAAGCTTATTTCTGAGGATAAGCTCTTTAAAGGCAAA GCTTTATTTTCATCTCTCATCTTTTGTCCTCCTTAGCACAATGTAAAAAAGAATAGTAATATCAGAACAG GAAGGAGGAATGGCTTGCTGGGGAGCCCATCCAGGACACTGGGAGCACATAGAGATTCACCCATGTTTGT TGAACTTAGAGTCATTCTCATGCTTTTCTTTATAATTCACACATATATGCAGAGAAGATATGTTCTTGTT AACATTGTATACAACATAGCCCCAAATATAGTAAGATCTATACTAGATAATCCTAGATGAAATGTTAGAG ATGCTATATGATACAACTGTGGCCATGACTGAGGAAAGGAGCTCACGCCCAGAGACTGGGCTGCTCTCCC GGAGGCCAAACCCAAGAAGGTCTGGCAAAGTCAGGCTCAGGGAGACTCTGCCCTGCTGCAGACCTCGGTG TGGACACACGCTGCATAGAGCTCTCCTTGAAAACAGAGGGGTCTCAAGACATTCTGCCTACCTATTAGCT TTTCTTTATTTTTTTAACTTTTTGGGGGGAAAAGTATTTTTGAGAAGTTTGTCTTGCAATGTATTTATAA ATAGTAAATAAAGTTTTTACCATTAAAAAAATATCTTTCCCTTTGTTATTGACCATCTCTGGGCTTTGTA TCACTAATTATTTTATTTTATTATATAATAATTATTTTATTATAATAAAATCCTGAAAGGGGAAAATA Download Select all
Length	9028
OMIM ID	146732
HGNC ID	HGNC:5472
Unigene ID	Hs.450230
Ensembl ID	ENSG00000146674
PharmGKB ID	-

mRNA Information

mRNA ID	NM_000598.4
Exon	join(1..535,3834..4060,4606..4725,6328..6468,7439..9028)
mRNA Sequence	>3486 AGATGCGAGCACTGCGGCTGGGCGCTGAGGATCAGCCGCTTCCTGCCTGGATTCCACAGCTTCG CGCCGTGTACTGTCGCCCCATCCCTGCGCGCCCAGCCTGCCAAGCAGCGTGCCCCGGTTGCAGG CGTCATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGCTGGTGCTGCTCCGC GGGCCGCCGGTGGCGCGGGCTGGCGCGAGCTCGGCGGGCTTGGGTCCCGTGGTGCGCTGCGAGC CGTGCGACGCGCGTGCACTGGCCCAGTGCGCGCCTCCGCCCGCCGTGTGCGCGGAGCTGGTGCG CGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGAGCGAGGGCCAGCCGTGCGGCATCTAC ACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAGGCGCGACCGCTGCAGG CGCTGCTGGACGGCCGCGGGCTCTGCGTCAACGCTAGTGCCGTCAGCCGCCTGCGCGCCTACCT GCTGCCAGCGCCGCCAGCTCCAGGAAATGCTAGTGAGTCGGAGGAAGACCGCAGCGCCGGCAGT GTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTGTCTGATCCCAAGTTCCACCCCCTCCATT CAAAGATAATCATCATCAAGAAAGGGCATGCTAAAGACAGCCAGCGCTACAAAGTTGACTACGA GTCTCAGAGCACAGATACCCAGAACTTCTCCTCCGAGTCCAAGCGGGAGACAGAATATGGTCCC TGCCGTAGAGAAATGGAAGACACACTGAATCACCTGAAGTTCCTCAATGTGCTGAGTCCCAGGG GTGTACACATTCCCAACTGTGACAAGAAGGGATTTTATAAGAAAAAGCAGTGTCGCCCTTCCAA AGGCAGGAAGCGGGGCTTCTGCTGGTGTGTGGATAAGTATGGGCAGCCTCTCCCAGGCTACACC ACCAAGGGGAAGGAGGACGTGCACTGCTACAGCATGCAGAGCAAGTAGACGCCTGCCGCAAGGT TAATGTGGAGCTCAAATATGCCTTATTTTGCACAAAAGACTGCCAAGGACATGACCAGCAGCTG GCTACAGCCTCGATTTATATTTCTGTTTGTGGTGAACTGATTTTTTTTAAACCAAAGTTTAGAA AGAGGTTTTTGAAATGCCTATGGTTTCTTTGAATGGTAAACTTGAGCATCTTTTCACTTTCCAG TAGTCAGCAAAGAGCAGTTTGAATTTTCTTGTCGCTTCCTATCAAAATATTCAGAGACTCGAGC ACAGCACCCAGACTTCATGCGCCCGTGGAATGCTCACCACATGTTGGTCGAAGCGGCCGACCAC TGACTTTGTGACTTAGGCGGCTGTGTTGCCTATGTAGAGAACACGCTTCACCCCCACTCCCCGT ACAGTGCGCACAGGCTTTATCGAGAATAGGAAAACCTTTAAACCCCGGTCATCCGGACATCCCA ACGCATGCTCCTGGAGCTCACAGCCTTCTGTGGTGTCATTTCTGAAACAAGGGCGTGGATCCCT CAACCAAGAAGAATGTTTATGTCTTCAAGTGACCTGTACTGCTTGGGGACTATTGGAGAAAATA AGGTGGAGTCCTACTTGTTTAAAAAATATGTATCTAAGAATGTTCTAGGGCACTCTGGGAACCT ATAAAGGCAGGTATTTCGGGCCCTCCTCTTCAGGAATCTTCCTGAAGACATGGCCCAGTCGAAG GCCCAGGATGGCTTTTGCTGCGGCCCCGTGGGGTAGGAGGGACAGAGAGACAGGGAGAGTCAGC CTCCACATTCAGAGGCATCACAAGTAATGGCACAATTCTTCGGATGACTGCAGAAAATAGTGTT TTGTAGTTCAACAACTCAAGACGAAGCTTATTTCTGAGGATAAGCTCTTTAAAGGCAAAGCTTT ATTTTCATCTCTCATCTTTTGTCCTCCTTAGCACAATGTAAAAAAGAATAGTAATATCAGAACA GGAAGGAGGAATGGCTTGCTGGGGAGCCCATCCAGGACACTGGGAGCACATAGAGATTCACCCA TGTTTGTTGAACTTAGAGTCATTCTCATGCTTTTCTTTATAATTCACACATATATGCAGAGAAG ATATGTTCTTGTTAACATTGTATACAACATAGCCCCAAATATAGTAAGATCTATACTAGATAAT CCTAGATGAAATGTTAGAGATGCTATATGATACAACTGTGGCCATGACTGAGGAAAGGAGCTCA CGCCCAGAGACTGGGCTGCTCTCCCGGAGGCCAAACCCAAGAAGGTCTGGCAAAGTCAGGCTCA GGGAGACTCTGCCCTGCTGCAGACCTCGGTGTGGACACACGCTGCATAGAGCTCTCCTTGAAAA CAGAGGGGTCTCAAGACATTCTGCCTACCTATTAGCTTTTCTTTATTTTTTTAACTTTTTGGGG GGAAAAGTATTTTTGAGAAGTTTGTCTTGCAATGTATTTATAAATAGTAAATAAAGTTTTTACC ATTAAAAAAATATCTTTCCCTTTGTTATTGACCATCTCTGGGCTTTGTATCACTAATTATTTTA TTTTATTATATAATAATTATTTTATTATAATAAAATCCTGAAAGGGGAAAATAAAAAAAA Download Select all
Length	2620

CDS Information

Location	join(133..535,3834..4060,4606..4725,6328..6453)
CDS Sequence	>lcl\|NM_000598.4_cds_NP_000589.2_1 [gene=IGFBP3] [protein=insulin-like growth factor-binding protein 3 isoform b precursor] [protein_id=NP_000589.2] [location=133..1008] ATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGCTGGTGCTGCTCCGCGGGCCGCCGG TGGCGCGGGCTGGCGCGAGCTCGGCGGGCTTGGGTCCCGTGGTGCGCTGCGAGCCGTGCGACGCGCGTGC ACTGGCCCAGTGCGCGCCTCCGCCCGCCGTGTGCGCGGAGCTGGTGCGCGAGCCGGGCTGCGGCTGCTGC CTGACGTGCGCACTGAGCGAGGGCCAGCCGTGCGGCATCTACACCGAGCGCTGTGGCTCCGGCCTTCGCT GCCAGCCGTCGCCCGACGAGGCGCGACCGCTGCAGGCGCTGCTGGACGGCCGCGGGCTCTGCGTCAACGC TAGTGCCGTCAGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGAAATGCTAGTGAGTCG GAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTGTCTGATCCCA AGTTCCACCCCCTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCTAAAGACAGCCAGCGCTACAA AGTTGACTACGAGTCTCAGAGCACAGATACCCAGAACTTCTCCTCCGAGTCCAAGCGGGAGACAGAATAT GGTCCCTGCCGTAGAGAAATGGAAGACACACTGAATCACCTGAAGTTCCTCAATGTGCTGAGTCCCAGGG GTGTACACATTCCCAACTGTGACAAGAAGGGATTTTATAAGAAAAAGCAGTGTCGCCCTTCCAAAGGCAG GAAGCGGGGCTTCTGCTGGTGTGTGGATAAGTATGGGCAGCCTCTCCCAGGCTACACCACCAAGGGGAAG GAGGACGTGCACTGCTACAGCATGCAGAGCAAGTAG Download Select all
CCDS ID	CCDS5505.1

Protein Information

Protein ID	NP_000589.2
Protein Name	insulin-like growth factor binding protein 3
Molecular Wt. (Da)	28750
Protein Sequence	>3486 MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVRE PGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLL PAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYES QSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKG RKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK Download Select all
Length	291
Uniprot ID	Q30201
Ensembl Protein ID	ENSP00000313776

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
N	Glycosylation	116
N	Glycosylation	142
K	Proteolytic Cleavage	182
K	Proteolytic Cleavage	183
K	Proteolytic Cleavage	187
N	Glycosylation	205
N	Glycosylation	116
N	Glycosylation	136
K	Proteolytic Cleavage	176
K	Proteolytic Cleavage	177
K	Proteolytic Cleavage	181
N	Glycosylation	199
S	Phosphorylation	144
S	Phosphorylation	146
S	Phosphorylation	138
S	Phosphorylation	140
H	Proteolytic Cleavage	175
L	Proteolytic Cleavage	236
H	Proteolytic Cleavage	169
L	Proteolytic Cleavage	230
Y	Proteolytic Cleavage	126
K	Proteolytic Cleavage	193
E	Proteolytic Cleavage	197
N	Proteolytic Cleavage	234
Y	Proteolytic Cleavage	126
K	Proteolytic Cleavage	187
E	Proteolytic Cleavage	191
N	Proteolytic Cleavage	228
K	Proteolytic Cleavage	177
K	Proteolytic Cleavage	171
L	Proteolytic Cleavage	123
Y	Proteolytic Cleavage	126
L	Proteolytic Cleavage	174
L	Proteolytic Cleavage	123
Y	Proteolytic Cleavage	126
L	Proteolytic Cleavage	168
Y	Proteolytic Cleavage	126
L	Proteolytic Cleavage	123
L	Proteolytic Cleavage	174
L	Proteolytic Cleavage	123
Y	Proteolytic Cleavage	126
L	Proteolytic Cleavage	168
R	Proteolytic Cleavage	122
R	Proteolytic Cleavage	124
A	Proteolytic Cleavage	27
K	Proteolytic Cleavage	193
R	Proteolytic Cleavage	122
R	Proteolytic Cleavage	124
K	Proteolytic Cleavage	187
R	Proteolytic Cleavage	124
R	Proteolytic Cleavage	165
Y	Proteolytic Cleavage	192
F	Proteolytic Cleavage	206
R	Proteolytic Cleavage	212
R	Proteolytic Cleavage	124
R	Proteolytic Cleavage	159
Y	Proteolytic Cleavage	186
F	Proteolytic Cleavage	200
R	Proteolytic Cleavage	206
R	Proteolytic Cleavage	239
R	Proteolytic Cleavage	124
R	Proteolytic Cleavage	233
R	Proteolytic Cleavage	124
N	Proteolytic Cleavage	142
Y	Proteolytic Cleavage	126
N	Proteolytic Cleavage	136
Y	Proteolytic Cleavage	126
A	Proteolytic Cleavage	27
A	Proteolytic Cleavage	27
A	Proteolytic Cleavage	27
K	Proteolytic Cleavage	253
K	Proteolytic Cleavage	231
R	Proteolytic Cleavage	191
H	Proteolytic Cleavage	175
K	Proteolytic Cleavage	247
K	Proteolytic Cleavage	225
R	Proteolytic Cleavage	185
H	Proteolytic Cleavage	169
E	Proteolytic Cleavage	209
E	Proteolytic Cleavage	203
S	Phosphorylation	207
S	Phosphorylation	201

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
857	CAV1	3028	NP_001744.2	in vitro	14576164
960	CD44	115	NP_000601.3	in vitro	12127836
1277	COL1A1	362	NP_000079.2	in vitro;in vivo;yeast 2-hybrid	12735930
2147	F2	1488	NP_000497.1	in vitro;in vivo	88 437 397 538 844
2335	FN1	626	NP_997647.1	in vitro;in vivo;yeast 2-hybrid	11344214
5340	PLG	1417	NP_000292.1	in vitro;in vivo	7 538 844 884 373 990 000 000 000 000
23649	POLA2	10160	NP_002680.2	yeast 2-hybrid	16169070

Pathway Information

Pathway Name	Pathway ID
p53 signaling pathway	hsa04115
Transcriptional misregulation in cancer	hsa05202

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00191	212-285	TY
cl00150	212-285	TY superfamily
smart00121	38-115	IB
cl02472	38-115	IGFBP superfamily
pfam00086	213-285	Thyroglobulin_1
pfam00219	40-94	IGFBP
smart00211	237-287	TY

Ontology Information

HPRD ID	809
Molecular Class	Growth inhibitory factor
Molecular Function	Catalytic activity (GO:0003824)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report

Drug Information

Uniprot ID DrugBank ID Name Type
P17936 DB01277 Mecasermin BiotechDrug

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO