CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
KLK3	354	kallikrein-related peptidase 3	19	PSA

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24927162	2014	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	-	Up-regulation	-	This multigene family hosts the most widely used cancer biomarker that is PSA-KLK3

Gene Details

NC_000019.9 (51358171..51364020)
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Gene Type	protein coding
Gene Family	Kallikreins
Description	Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	19
Location	19q13.41
Start	51358171
End	51364020
Strand	+
Gene Sequence	>gi\|568815579:50854915-50877702 Homo sapiens chromosome 19, GRCh38.p2 Primary Assembly AGCCCCAAGCTTACCACCTGCACCCGGAGAGCTGTGTCACCATGTGGGTCCCGGTTGTCTTCCTCACCCT GTCCGTGACGTGGATTGGTGAGAGGGGCCATGGTTGGGGGGATGCAGGAGAGGGAGCCAGCCCTGACTGT CAAGCTGAGGCTCTTTCCCCCCCAACCCAGCACCCCAGCCCAGACAGGGAGCTGGGCTCTTTTCTGTCTC TCCCAGCCCCACTCCAAGCCCATACCCCCAGCCCCTCCATATTGCAACAGTCCTCACTCCCACACCAGGT CCCCGCTCCCTCCCACTTACCCCAGAACTTTCTCCCCATTGCCCAGCCAGCTCCCTGCTCCCAGCTGCTT TACTAAAGGGGAAGTTCCTGGGCATCTCCGTGTTTCTCTTTGTGGGGCTCAAAACCTCCAAGGACCTCTC TCAATGCCATTGGTTCCTTGGACCGTATCACTGGTCCACCTCCTGAGCCCCTCAATCCTATCACAGTCTA CTGACTTTTCCCATTCAGCTGTGAGTGCCCAACCCTATCCCAGAGACCTTGATGCTTGGCCTCCCAATCT TGCCCTAGGATACCCAGATGCCAACCAGACACCTCCTTCTTCCTAGCCAGGCTATCTGGCCTGAGACAAC AAATGGGTCCCTCAGTCTGGCAATGGGACTCTGAGAACTCCTCATTCCCTGACTCTTAGCCCCAGACTCT TCATTCAGTGGCCCACATTTTCCTTAGGAAAAACATGAGCATCCCCAGCCACAACTGCCAGCTCTCTGAT TCCCCAAATCTGCATCCTTTTCAAAACCTAAAAACAAAAAGAAAAACAAATAAAACAAAACCAACTCAGA CCAGAACTGTTTTCTCAACCTGGGACTTCCTAAACTTTCCAAAACCTTCCTCTTCCAGCAACTGAACCTC GCCATAAGGCACTTATCCCTGGTTCCTAGCACCGCTTATCCCCTCAGAATCCACAACTTGTACCAAGTTT CCCTTCTCCCAGTCCAAGACCCCAAATCACCACAAAGGACCCAATCCCCAGACTCAAGATATGGTCTGGG CGCTGTCTTGTGTCTCCTACCCTGATCCCTGGGTTCAACTCTGCTCCCAGAGCATGAAGCCTCTCCACCA GCACCAGCCACCAACCTGCAAACCTAGGGAAGATTGACAGAATTCCCAGCCTTTCCCAGCTCCCCCTGCC CATGTCCCAGGACTCCCAGCCTTGGTTCTCTGCCCCCGTGTCTTTTCAAACCCACATCCTAAATCCATCT CCTATCCGAGTCCCCCAGTTCCTCCTGTCAACCCTGATTCCCCTGATCTAGCACCCCCTCTGCAGGTGCT GCACCCCTCATCCTGTCTCGGATTGTGGGAGGCTGGGAGTGCGAGAAGCATTCCCAACCCTGGCAGGTGC TTGTGGCCTCTCGTGGCAGGGCAGTCTGCGGCGGTGTTCTGGTGCACCCCCAGTGGGTCCTCACAGCTGC CCACTGCATCAGGAAGTGAGTAGGGGCCTGGGGTCTGGGGAGCAGGTGTCTGTGTCCCAGAGGAATAACA GCTGGGCATTTTCCCCAGGATAACCTCTAAGGCCAGCCTTGGGACTGGGGGAGAGAGGGAAAGTTCTGGT TCAGGTCACATGGGGAGGCAGGGTTGGGGCTGGACCACCCTCCCCATGGCTGCCTGGGTCTCCATCTGTG TTCCTCTATGTCTCTTTGTGTCGCTTTCATTATGTCTCTTGGTAACTGGCTTCGGTTGTGTCTCTCCGTG TGACTATTTTGTTCTCTCTCTCCCTCTCTTCTCTGTCTTCAGTCTCCATATCTCCCCCTCTCTCTGTCCT TCTCTGGTCCCTCTCTAGCCAGTGTGTCTCACCCTGTATCTCTCTGCCAGGCTCTGTCTCTCGGTCTCTG TCTCACCTGTGCCTTCTCCCTACTGAGCACACGCATGGGATGGGCCTGGGGGGACCCTGAGAAAAGGAAG GGCTTTGGCTGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTAGATCAC CTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACTGGTGAAACCCCATCTCTACTAAAAATACAAAAAAT TAGCCAGGCGTGGTGGCGCATGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGGAGGAGAATTGCTTGAA CCTGGGAGGTGGAGGTTGCAGTGAGCCGAGACCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGAC TCCGCCTCAAAAAAAAAAAAAAAAAAAAAGAAAAGAAAAGAAAAGAAAAGGAAGTGTTTTATCCCTGATG TGTGTGGGTATGAGGGTATGAGAGGGCCCCTCTCACTCCATTCCTTCTCCAGGACATCCCTCCACTCTTG GGAGACACAGAGAAGGGCTGGTTCCAGCTGGAGCTGGGAGGGGCAATTGAGGGAGGAGGAAGGAGAAGGG GGAAGGAAAACAGGGTATGGGGGAAAGGACCCTGGGGAGCGAAGTGGAGGATACAACCTTGGGCCTGCAG GCCAGGCTACCTACCCACTTGGAAACCCACGCCAAAGCCGCATCTACAGCTGAGCCACTCTGAGGCCTCC CCTCCCCAGCGGTCCCCACTCAGCTCCAAAGTCTCTCTCCCTTTTCTCTCCCACACTCTATCATCCCCCG GATTCCTCTCTACTTGGTTCTCATTCTTCCTTTGACTTCCTGCTTCCCTTTCTCATTCATCTGTTTCTCA CTTTCTGCCTGGTTTTGTTCTTCTCTCTCTCTTTCTCTGGCCCATGTCTGTTTCTCTATGTTTCTGTCTT TTCTTTCTCATCCTGTGTATTTTCGGCTCACCTTGTTTGTCACTGTTCTCCCCTCTGCCCTTTCATTCTC TCTGTCCTTTTACCCTCTTCCTTTTTCCCTTGGTTTCTCTCAGTTTCTGTATCTGCCCTTCACCCTCTCA CACTGCTGTTTCCCAACTCGTTGTCTGTATTTTTGGCCTGAACTGTGTCTTCCCCAACCCTGTGTTTTTC TCACTGTTTCTTTTTCTCTTTTGGAGCCTCCTCCTTGCTCCTCTGTCCCTTCTCTCTTTCCTTATCATCC TCGCTCCTCATTCCTGCGTCTGCTTCCTCCCCAGCAAAAGCGTGATCTTGCTGGGTCGGCACAGCCTGTT TCATCCTGAAGACACAGGCCAGGTATTTCAGGTCAGCCACAGCTTCCCACACCCGCTCTACGATATGAGC CTCCTGAAGAATCGATTCCTCAGGCCAGGTGATGACTCCAGCCACGACCTCATGCTGCTCCGCCTGTCAG AGCCTGCCGAGCTCACGGATGCTGTGAAGGTCATGGACCTGCCCACCCAGGAGCCAGCACTGGGGACCAC CTGCTACGCCTCAGGCTGGGGCAGCATTGAACCAGAGGAGTGTACGCCTGGGCCAGATGGTGCAGCCGGG AGCCCAGATGCCTGGGTCTGAGGGAGGAGGGGACAGGACTCCTAGGTCTGAGGGAGGAGGGCCAAGGAAC CAGGTGGGGTCCAGCCCACAACAGTGTTTTTGCCTGGCCCGTAGTCTTGACCCCAAAGAAACTTCAGTGT GTGGACCTCCATGTTATTTCCAATGACGTGTGTGCGCAAGTTCACCCTCAGAAGGTGACCAAGTTCATGC TGTGTGCTGGACGCTGGACAGGGGGCAAAAGCACCTGCTCGGTGAGTCATCCCTACTCCCAAGATCTTGA GGGGAAAGGTGAGTGGGGACCTTAATTCTGGGCTGGGGTCTAGAAGCCAACAAGGCGTCTGCCTCCCCTG CTCCCCAGCTGTAGCCATGCCACCTCCCCGTGTCTCATCTCATTCCCTCCTTCCCTCTTCTTTGACTCCC TCAAGGCAATAGGTTATTCTTACAGCACAACTCATCTGTTCCTGCGTTCAGCACACGGTTACTAGGCACC TGCTATGCACCCAGCACTGCCCTAGAGCCTGGGACATAGCAGTGAACAGACAGAGAGCAGCCCCTCCCTT CTGTAGCCCCCAAGCCAGTGAGGGGCACAGGCAGGAACAGGGACCACAACACAGAAAAGCTGGAGGGTGT CAGGAGGTGATCAGGCTCTCGGGGAGGGAGAAGGGGTGGGGAGTGTGACTGGGAGGAGACATCCTGCAGA AGGCGGGAGTGAGCAAACACCTGCCGCAGGGGAGGGGAGGGCCCTGCGGCACCTGGGGGAGCAGAGGGAA CAGCATCTGGCCAGGCCTGGGAGGAGGGGCCTAGAGGGCGTCAGGAGCAGAGAGGAGGTTGCCTGGCTGG AGTGAAGGATCGGGGCAGGGTGCGAGAGGGAAGAAAGGACCCCTCCTGCAGGGCCTCACCTGGGCCACAG GAGGACACTGCTTTTCCTCTGAGGAGTCAGGAACTGTGGATGGTGCTGGACAGAAGCAGGACAGGGCCTG GCTCAGGTGTCCAGAGGCTGCCGCTGGCCTCCCTATGGGATCAGACTGCAGGGAGGGAGGGCAGCAGGGA TGTGGAGGGAGTGATGATGGGGCTGACCTGGGGGTGGCTCCAGGCATTGTCCCCACCTGGGCCCTTACCC AGCCTCCCTCACAGGCTCCTGGCCCTCAGTCTCTCCCCTCCACTCCATTCTCCACCTACCCACAGTGGGT CATTCTGATCACCGAACTGACCATGCCAGCCCTGCCGATGGTCCTCCATGGCTCCCTAGTGCCCTGGAGA GGAGGTGTCTAGTCAGAGAGTAGTCCTGGAAGGTGGCCTCTGTGAGGAGCCACGGGGACAGCATCCTGCA GATGGTCCTGGCCCTTGTCCCACCGACCTGTCTACAAGGACTGTCCTCGTGGACCCTCCCCTCTGCACAG GAGCTGGACCCTGAAGTCCCTTCCCCACCGGCCAGGACTGGAGCCCCTACCCCTCTGTTGGAATCCCTGC CCACCTTCTTCTGGAAGTCGGCTCTGGAGACATTTCTCTCTTCTTCCAAAGCTGGGAACTGCTATCTGTT ATCTGCCTGTCCAGGTCTGAAAGATAGGATTGCCCAGGCAGAAACTGGGACTGACCTATCTCACTCTCTC CCTGCTTTTACCCTTAGGGTGATTCTGGGGGCCCACTTGTCTGTAATGGTGTGCTTCAAGGTATCACGTC ATGGGGCAGTGAACCATGTGCCCTGCCCGAAAGGCCTTCCCTGTACACCAAGGTGGTGCATTACCGGAAG TGGATCAAGGACACCATCGTGGCCAACCCCTGAGCACCCCTATCAACCCCCTATTGTAGTAAACTTGGAA CCTTGGAAATGACCAGGCCAAGACTCAAGCCTCCCCAGTTCTACTGACCTTTGTCCTTAGGTGTGAGGTC CAGGGTTGCTAGGAAAAGAAATCAGCAGACACAGGTGTAGACCAGAGTGTTTCTTAAATGGTGTAATTTT GTCCTCTCTGTGTCCTGGGGAATACTGGCCATGCCTGGAGACATATCACTCAATTTCTCTGAGGACACAG ATAGGATGGGGTGTCTGTGTTATTTGTGGGGTACAGAGATGAAAGAGGGGTGGGATCCACACTGAGAGAG TGGAGAGTGACATGTGCTGGACACTGTCCATGAAGCACTGAGCAGAAGCTGGAGGCACAACGCACCAGAC ACTCACAGCAAGGATGGAGCTGAAAACATAACCCACTCTGTCCTGGAGGCACTGGGAAGCCTAGAGAAGG CTGTGAGCCAAGGAGGGAGGGTCTTCCTTTGGCATGGGATGGGGATGAAGTAAGGAGAGGGACTGGACCC CCTGGAAGCTGATTCACTATGGGGGGAGGTGTATTGAAGTCCTCCAGACAACCCTCAGATTTGATGATTT CCTAGTAGAACTCACAGAAATAAAGAGCTGTTATACTGTGGTTTATTCTGGTTTGTTACATTGACAGGAG ACACACTGAAATCAGCAAAGGAAACAGGCATCTAAGTGGGGATGTGAAGAAAACAGGGAAAATCTTTCAG TTGTTTTCTCCCAGTGGGGTGTTGTGGACAGCACTTAAATCACACAGAAGTGATGTGTGACCTTGTGTAT GAAGTATTTCCAACTAAGGAAGCTCACCTGAGCCTTAGTGTCCAGAGTTTTTATTGGGGGTCTGTAGGAT AGGCATGGAGTACTGGAATAGCTGACCTTAACTTCTCAGACCTGAGGTTCCCAAGAGTTCAAGCAGATAC AGCATGGCCTAGAGCCTCAGATGTACAAAAACAGGCATTCATCATGAATCGCACTGTTAGCATGAATCAT CTGGCACGGCCCAAGGCCCCAGGTATACCAAGGCACTTGGGCCGAATGTTCCAAGGGATTAAATGTCATC TCCCAGGAGTTATTCAAGGGTGAGCCCTGTACTTGGAACGTTCAGGCTTTGAGCAGTGCAGGGCTGCTGA GTCAACCTTTTACTGTACAGGGGGGTGAGGGAAAGGGAGAAGATGAGGAAACCGCCTAGGGATCTGGTTC TGTCTTGTGGCCAAGTGGACCATGGGGCTATCCCAAGAAGGAGGAATTCAGAAATAGGGGAAGGTTGAGG AAGGACACTGAACTCAAAGGGGATACAGTGATTGGTTTATTTGTCTTCTCTTCACAACATTGGTGCTGGA GGAATTCCCACCCTGAGGTTATGAAGATGTCTGAACACCCAACACATAGCACTGGAGATATGAGCTCGAC AAGAGTTTCTCAGCCACAGAGATTCACAGCCTAGGGCAGGAGGACACTGTACACCAGGCAGAATGACATG GGAATTGCGCTCACGATTGGCTTGAAGAAGCAAGGACTGTGGGAGGTGGGCTTTGTAGTAACAAGAGGGC AGGGTGAACTCTGATTCCCATGGGGGAATGTGATGGTCCTGTTACAAATTTTTCAAGCTGGCAGGGAATA AAACCCATTACGGTGAGGACCTGTGGAGGGCGGCTGCCCCAACTGATAAAGGAAATAGCCAGGTGGGGGC CTTTCCCATTGTAGGGGGGACATATCTGGCAATAGAAGCCTTTGAGACCCTTTAGGGTACAAGTACTGAG GCAGCAAATAAAATGAAATCTTATTTTTCAACTTTATACTGCATGGGTGTGAAGATATATTTGTTTCTGT ACAGGGGGTGAGGGAAAGGAGGGGAGGAGGAAAGTTCCTGGAGGTCTGGTTTGGTCTTGTGATCCAGGGG GTCTTGGAACTATTTAAATTAAATTAAATTAAAACAAGCGACTGTTTTAAATTAAATTAAATTAAATTAA ATTAAATTAAATTAAATTTTACTTTATTTTATCTTAAGTTCTGGGCTACATGTGCAGGACGTGCAGCTTT GTTACATAGGTAAACATGTGCCATGGTGGTTTGCTGTACCTATCAACCCATCACCTAGGTATTAAGCCCA GCATGCATTAGCTGTTTTTCCTGACGCTCTCCCTCTCCCTGACTCCCACAACAGGCCCCAGTGTGTGTTG TTCCCCTCCCTGTGTCCATGTGTTCTCATTGTTCAGCTCCCACTTATAAGTGAGAACATGTGGTGTTTGG TTTTCTGTTTCTGTGTTAGTTTGCTGAGGATAATGGCTTCCACCTCCATCCATGTTCCTGCAAAGGACGT GATCTTATTCTTTTTTATGGTTGCATAGAAATTGTTTTTACAAATCCAATTGATATTGTATTTAATTACA AGTTAATCTAATTAGCATACTAGAAGAGATTACAGAAGATATTAGGTACATTGAATGAGAAAATATATAA AATAGGACGAAGGTGAAATATTAGGTAGGAAAAGTATAATAGTTGAAAGAAGTAAAAAAAAATATGCATG AGTAGCAGAATGTAAAAGAGGTGAAGAACGTAATAGTGACTTTTTAGACCAGATTGAAGGACAGAGACAG AAAAATTTTAAGGAATTGCTAAACCATGTGAGTGTTAGAAGTACAGTCAATAACATTAAAGCCTCAGGAG GAGAAAAGAATAGGAAAGGAGGAAATATGTGAATAAATAGTAGAGACATGTTTGATGGATTTTAAAATAT TTGAAAGACCTCACATCAAAGGATTCATACCGTGCCATTGAAGAGGAAGATGGAAAAGCCAAGAAGCCAG ATGAAAGTTAGAAATATTATTGGCAAAGCTTAAATGTTAAAAGTCCTAGAGAGAAAGGATGGCAGAAATA TTGGCGGGAAAGAATGCAGAACCTAGAATATAAATTCATCCCAACAGTTTGGTAGTGTGCAGCTGTAGCC TTTTCTAGATAATACACTATTGTCATACATCGCTTAAGCGAGTGTAAAATGGTCTCCTCACTTTATTTAT TTATATATTTATTTAGTTTTGAGATGGAGCCTCGCTCTGTCTCCTAGGCTGGAGTGCAATAGTGCGATAC CACTCACTGCAACCTCTGCCTCCTCTGTTCAAGTGATTTTCTTACCTCAGCCTCCCGAGTAGCTGGGATT ACAGGTGCGTGCCACCACACCCGGCTAATTTTTGTATTTTTTGTAGAGACGGGGTTTTGCCATGTTGGCC AGGCTGGTCTTGAACTCCTGACATCAGGTGATCCACCTGCCTTGGCCTCCTAAAGTGCTGGGATTACAGG CATGAGCCACCGTGCCCAATCACTTTATTTATTTTTTATTTTTATTTTTAAATTTCAGCTTCTATTTGAA ATACAGGGGGCACATATATAGGATTGTTACATGGGTATATTGAACTCAGGTAGTGATCATACTACCCAAC AGGTAGGTTTTCAACCCACTCCCCCTCTTTTCCTCCCCATTCTAGTAGTGTGCAGTGTCTATTGTTCTCA TGTTTATGTCTATGTGTGCTCCAGGTTTAGCTCCCACCTGTAAGTGAGAACGTGTGGTATTTGATTTTCT GTCCCTGTGTTAATTCACTTAGGATTATGGCTTCCAGCTCCATTCATATTGCTGTAAAGGATATGATTCA TTTTTCATGGCCATGCAGTATTCCATATTGCGTATAGATCACATTTTCTTTCTTTTTTTTTTTTGAGACG GAGTCTTGCTTTGCTGCCTAGGCTGGAGTGCAGTAGCACGATCTCGGCTCACTGCAAGCTTCACCTCCGG GGTTCACGTCATTCTTCTGTCTCAGCTTCCCAAGTAGCTGGGACTACAGGCGCCCGCCACCACGTCCGGC TAATTTTTTTGTGTGTTTTTAGTAGAGATGGGGGTTTCACTGTGTTAGCCAGGATGGTCTTGATCTCCTG ACCTTGTGGTCCACCTGCCTCGGTCTCCCAAAGTGCTGGGATTACAGGGGTGAGCCACTGCGCCCGGCCC ATATATACCACATTTTCTTTAACCAATCCACCATTGATGGGCAACTAGGTAGATTCCATGGATTCCACAG TTTTGCTATTGTGTGCAGTGTGGCAGTAGACATATGAATGAATGTGTCTTTTTGGTATAATGATTTGCAT TCCTTTGGGTATACAGTCATTAATAGGAGTGCTGGGTTGAACGGTGGCTCTGTTTAAAATTCTTTGAGAA TTTTCCAAACTGTTTGCCATAGAGAACAAACTAATTTACATTTCCACGAACAGTATATAAGCATTCCCTT TTCTCCACAGCTTTGTCATCATGGTTTTTTTTTCTTTATTTTAAAAAAGAATATGTTGTTGTTTTCCCAG GGTACATGTGCAGGATGTGCAGGTTTGTTACATAGGTAGTAAACGTGAGCCATGGTGGTTTGCTGCACCT GTCAACCCATTACCTGGGTATGAAGCCCTGCCTGCATTAGCTCTTTTCCCTAATGCTCTCACTACTGCCC CACCCTCACCCTGACAGGGCAAACAGACAACCTACAGAATGGGAGGAAATTTTTGCAATCTATTCATCTG ACAAAGGTCAAGAATATCCAGAATCTACAAGGAACTTAAGCAAATTTTTACTTTTTAATAATAGCCACTC TGACTGGCGTGAAATGGTATCTCATTGTGGTTTTCATTTGAATTTCTCTGATGATCAGTGACAATGAGCA TTTTTTCATATTTGTTGGCTGCTTGTACGTCTTTTGAGAAGTGTCTCTTCATGCCTTTTGGCCACTTTAA TGGGATTATTTTTTGCTTTTTAGTTTAAGTTCCTTATAGATTCTGGATATTAGACTTCTTATTGGATGCA TAGTTTGTGAATACTCTCTTCCATTCTGTAGGTTGTCTGTTTACTCTATTGATGGCTTCTTTTGCTGTGC CGAAGCATCTTAGTTTAATTAGAAACCACCTGCCAATTTTTGTTTTTGTTGCAATTGCTTTTGGGGACTT AGTCATAAACTCTTTGCCAAGGTCTGGGTCAAGAAGAGTATTTCCTAGGTTTTCTTCTAGAATTTTGAAA GTCTGAATGTAAACATTTGCATTTTTAATGCATCTTGAGTTAGCTTTTGTATATGTGAAAGGTCTACTCT CATTTTCTTTCCCTCTTTCTTTCTTTCTTTTCTTTCCCTCTTTCTTTCTTTCTTTTCTTTCTTTCTTTCT TTCTTTCTTTCTTTCTTTCTTTCTTTCTTTTTGTCCTTCTTTCTTTCTTTCTCTTTCTTTCTCTCTTTCT TTTTTTTTTTTTTTGATGGAGTATTGCTCTGTTGCCCAGGCTGCAGTGCAGTGGCACGATCTTGGCTCAC TGCAACCTCTGCCTCCTGGGTTCAACTGATTCTCCTGCATCAGCCTTCCAAGTAGCTGGGATTATAGGCG CCCGCCACCACGCCCGACTAATTTTTGTATTTTTAGTAGAGACGGGGTTGTGCCATGTTGGCCAGGCTGG TTTGAAACTCCTGACCTCAAACGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGC CACTGTGCCCAGCCAAGAATGTCATTTTCTAAGAGGTCCAAGAACCTCAAGATATTTTGGGACCTTGAGA AGAGAGGAATTCATACAGGTATTACAAGCACAGCCTAATGGCAAATCTTTGGCGTGGCTTGGCTTCAAGA CTTTAGGCTCTTAAAAGTCGAATCCAAAATTTTTTATAAAAGCTCCAGCTAAGCTACCTTAAAAGGGGCC TGTATGGCTGATCACTCTTCTTGCTATACTTTACACAAATAAACAGGCCAAATATAATGAGGCCAAAATT TATTTTGCAAATAAATTGGTCCTGCTATGATTTACTCTTGGTAAGAACAGGGAAAATAGAGAAAAATTTA GATTGCATCTGACCTTTTTTTCTGAATTTTTATATGTGCCTACAATTTGAGCTAAATCCTGAATTATTTT CTGGTTGCAAAAACTCTCTAAAGAAGAACTTGGTTTTCATTGTCTTCGTGACACATTTATCTGGCTCTTT ACTAGAACAGTTTTCTTGTTTTTGGTGTTCTAGCTTGTGTGCCTTACAGTTCTACTCTTCAAATTATTGT TATGTGTATCTCATAGTTTTCCTTCTTTTGAGAAAACTGAAGCCATGGTATTCTGAGGACTAGAGATGAC TCAACACAGCTGGTGAATCTCCTCATATGCAATCCACTGGGCTTGATCTGCTTCAGATTGCTGATGCACT GCTGCTAAAGCTATACATTTAAAACCCTCACTAAAGGATCAGGGACCATCATGGAAGAGGAGGAAACATG AAATTGTAAGAGCCAGATTCGGGGGGTAGAGTGTGGAGGTCAGAGCAACTCCACCTTGAATAAGAAGGTA AAGCAACCTATCCTGAAAGCTAACCTGCCATGGTGGCTTCTGATTAACCCCTGTTCTGGGAAGACTGACA GTTTGGGTCTGTGTCATTGCCCAAATCTCATGTTAAATTGTAATCCCCAGTGTTCGGAGGTGGGACTTGG TGGTAGGTGATTCGGTCATGGGAGTAGATTTTCTTCTTTGTGGTGTTACAGTGATAGTGAGTGAGTTCTC GTGAGATCTGGTCATTTAAAAGTGTGTGGCCCCTCCCCTCCCTCTCTTGGTCCTCCTACTGCCATGTAAG ATACCTGCTCCTGCTTTGCCTTCTACCATAAGTAAAAGCCCCCTGAGGCCTCCCCAGAAGCAGATGCCAC CATGCTTCCTGTACAGCCTGCAGAACCATCAGCCAATTAAACCTCTTTTCTGTATAAATTACCAGTCTTG AGTATTTCTTTACAGCAGTGTGAGAACGGACTAATACAAGGATCTCCAAAATTCCAAGTTTATGTATTCT TTCTTGCCAAATAGCAGGTATTTACCATAAATCCTGTCCTTAGGTCAAACAACCTTGATGGCATCGTACT TCAATTGTCTTACACATTCCTTCTGAATGACTCCTCCCCTATGGCATATAAGCCCTGGGTCTTGGGGGAT AATGGCAGAGGGGTCCACCATCTTGTCTGGCTGCCACCTGAGACACAGACATGGCTTCTGTTGGTAAGTC TCTATTAAATGTTTCTTTCTAAGAAACTGGATTTGTCAGCTTGTTTCTTTGGACTCTCAGCTTCCTCAGA CTTTGGGGTAGGTTGCACAACCCTGCCCACCATGAAACAAATGTTTAATATGATAAATATGGATAGATAT AATCCACATAAATAAAAGCTCTTGGAGGGCCCTCAATAATTGTTAAGAGTGTAAATGTGTCCAAAGATGG AAAATGTTTGAGAACTACTGTCCCAGAGATTTTCCTGAGTTCTAGAGTGTGGGAATATAGAACCTGGAGC TTGGCTTCTTCAGCCTAGAATCAGGAGTATGGGGCTGAAGTCTGAAGCTTGGCTTCAGCAGTTTGGGGTT GGCTTCCGGAGCACATATTTGACATGTTGCGACTGTGGTTTGGGGTTTGGTATTTGCTCTGAATCCTAAT GTCTGTCCTTGAGGCATCTAGAATCTGAAATCTGTGGTCAGAATTCTATTATCTTGAGTAGGACATCTCC AGTCCTGGTTCTGCCTTCTAGGGCTGGAGTCTGTAGTCAGTGACCCGGTCTGGCATTTCAACTTCATATA CAGTGGGCTATCTTTTGGTCCATGTTTCAACCAAACAACCGAATAAACCATTAGAACCTTTCCCCACTTC CCTAGCTGCAATGTTAAACCTAGGATTTCTGTTTAATAGGTTCATATGAATAATTTCAGCCTGATCCAAC TTTACATTCCTTCTACCGTTATTCTACACCCACCTTAAAAATGCATTCCCAATATATTCCCTGGATTCTA CCTATATATGGTAATCCTGGCTTTGCCAGTTTCTAGTGCATTAACATACCTGATTTACATTCTTTTACTT TAAAGTGGAAATAAGAGTCCCTCTGCAGAGTTCAGGAGTTCTCAAGATGGCCCTTACTTCTGACATCAAT TGAGATTTCAAGGGAGTCACCAAGATCATCCTCAGGTTCAGTGATTGCTGGTAGCCCTCATATAACTCAA TGAAAGCTGTTATGCTCATGGCTATGGTTTATTACAGCAAAAGAATAGAGATGAAAATCTAGCAAGGGAA GAGTTGCATGGGGCAAAGACAAGGAGAGCTCCAAGTGCAGAGATTCCTGTTGTTTTCTCCCAGTGGTGTC ATGGAAAGCAGTATCTTCTCCATACAATGATGTGTGATAATATTCAGTGTATTGCCAATCAGGGAACTCA ACTGAGCCTTGATTATATTGGAGCTTGGTTGCACAGACATGTCGACCACCTTCATGGCTGAACTTTAGTA CTTAGCCCCTCCAGACGTCTACAGCTGATAGGCTGTAACCCAACATTGTCACCATAAATCACATTGTTAG ACTATCCAGTGTGGCCCAAGCTCCCGTGTAAACACAGGCACTCTAAACAGGCAGGATATTTCAAAAGCTT AGAGATGACCTCTCAGGAGCTGAATGCAAAGACCTGGCCTCTTTGGGCAAGGAGAATCCTTTACTGCACA CTCTCCTTCACAGGGTTATTGTGAGGATCAAATGTGGTCATGTGTGTGAGACACCAGCACATGTCTGGCT GTGGAGAGTGACTTCTATGTGTGCTAACATTGCTGAGTGCTAAGAAAGTATTAGGCATGGCTTTCAGCAC TCACAGATGCTCATCTAATCCTCACAACATGGCTACAGGGTGGGCACTACTAGCCTCATTTGACAGAGGA AAGGACTGTGGATAAGAAGGGGGTGACCAATAGGTCAGAGTCATTCTGGATGCAAGGGGCTCCAGAGGAC CATGATTAGACATTGTCTGCAGAGAAATTATGGCTGGATGTCTCTGCCCCGGAAAGGGGGATGCACTTTC CTTGACCCCCTATCTCAGATCTTGACTTTGAGGTTATCTCAGACTTCCTCTATGATACCAGGAGCCCATC ATAATCTCTCTGTGCCCTCTCCCCTTCCTCAGTCTTACTGCCCACTCTTCCCAGCTCCATCTCCAGCTGG CCAGGTGTAGCCACAGTACCTAACTCTTTGCAGAGAACTATAAATGTGTATCCTACAGGGGAGAAAAAAA AAAGAACTCTGAAAGAGCTGACATTTTACCGACTTGCAAACACATAAGCTAACCTGCCAGTTTTGTGCTG GTAGAACTCATGAGACTCCTGGGTCAGAGGCAAAAGATTTTATTACCCACAGCTAAGGAGGCAGCATGAA CTTTGTGTTCACATTTGTTCACTTTGCCCCCCAATTCATATGGGATGATCAGAGCAGTTCAGGTGGATGG ACACAGGGGTTTGTGGCAAAGGTGAGCAACCTAGGCTTAGAAATCCTCAATCTTATAAGAAGGTACCAGC AAACTTGTCCAGTCTTTGTATCTGACGGAGATATTATCTTTATAATTGGGTTGAAAGCAGACCTACTCTG GAGGAACATATTGTATTTATTGTCCTGAACAGTAAACAAATCTGCTGTAAAATAGACGTTAACTTTATTA TCTAAGGCAGTAAGCAAACCTAGATCTGAAGGCGATACCATCTTGCAAGGCTATCTGCTGTACAAATATG CTTGAAAAGATGGTCCAGAAAAGAAAACGGTATTATTGCCTTTGCTCAGAAGACACACAGAAACATAAGA GAACCATGGAAAATTGTCTCCCAACACTGTTCACCCAGAGCCTTCCACTCTTGTCTGCAGGACAGTCTTA ACATCCCATCATTAGTGTGTCTACCACATCTGGCTTCACTGTGCCTAACCAAGATTTCTAGGTCCAGTTC CCCACCATGTTTGGCAGTGCCCCACTGCCAACCCCAGAATAAGGGAGTGCTCAGAATTTCGAGGGGACAT GGGTGGGGATCAGAACTTCTGGGCTTGAGTGCAGAGGGGGCCCATACTCCTTGGTTCCGAAGGAGGAAGA GGCTGGAGGTGAATGTCCTTGGAGAGGAGGAATGTGGGTTCTGAACTCTTAAATCCCCAAGGGAGGAGAC TGGTAAGGTCCCAGCTTCCGAGGTACTGACGTGGGAATGGCCTGAGAGGTCTAAGAATCCCGTATCCTCG GGAAGAAGGGGCTGAAATTGTGAGGGGTTGAGTTGCAGGGGTTTGTTAGCTTGAGACTCCTTGGTGGGTC CCTGGGAAGCAAGGACTGGAACCATTGGCTCCAGGGTTTGGTGTGAAGGTAATGGAATCTCCTGATTCTC AAAGGGTCAGAGGACTGAGAGTTGCCCATGCTTTGATCTTTCCATCTACTCCTTACTCCACTTGAGGGTA ATCACCTACTCTTCTAGTTCCACAAGAGTGCGCCTGCGCGAGTATAATCTGCACATGTGCCATGTCCCGA GGCCTGGGGCATCATCCACTCATCATTCAGCATCTGCACTATGCGGGCGAGGCCGGCGCCATGACGTCAT GTAGCTGCGACTATCCCTGCAGCGCGCCTCTCCCGTCACGTCCCAACCATGGAGCTGTGGACGTGCGTCC CCTGGTGGATGTGGCCTGCGTGGTGCCAGGCCGGGGCCTGGTGTCCGATAAAGATCCTAGAACCACAGGA AACCAGGACTGAAAGGTGCTAGAGAATGGCCATATGTCGCTGTCCATGAAATCTCAAGGACTTCTGGGTG GAGGGCACAGGAGCCTGAACTTACGGGTTTGCCCCACTCCACTGTCCTCCCAAGTGAGTCTCCCAGATAC GAGGCACTGTGCCAGCATCAGCTTCATCTGTACCACATCTTGTAACAGGGACTACCCAGGGCCCTGATGA ACACCATGGTGTGTGCAGGAAGAGCGGGTGAAGGCACGGACTCCTGTGTGGTCAGAGCCCAGAGGGGGCC ATGACGGGTGGGGAGGAGGCTGTGGACTGGCTCGAGAAGTGGGATGTGGTTGTGTTTGATCTCCTTTGGC CAGATAAAGTGCTGGATATAGCATTGAAAACGGAGTATGAAGACCAGTTAGAATGGAGGGTCAGGTTGGA GTTGAGTTACAGATGGGGTAAAATTCTGCTTCGGATGAGTTTGGGGATTGGCAATTTAAAGGTGGTTTGG GATGGCATGGCTTTGGGATGGAAATAGGTTTGTTTTTATGTTGGCTGGGAAGGGTGTGGGGATTGAATTG GGGATGAAGTAGGTTTAGTTTTGGAGATAGAATACATGGAGCTGGCTATTGCATGCGAGGATGTGCATTA GTTTGGTTTGATCTTTAAATGAAGGAGGCTATTAGGGTTGTCTTGAATTAGATTAAGTTGTGTTGGGTTG ATGGGTTGGGCTTGTGGGTGATGTGGTTGGATTGGGCTGTGTTAAATTGGTTTGGGTCAGGTTTTGGTTG AGGTTATCATGGGGATGAGGATATGCTTGGGACACTGGATTCAGGTGGTTCTCATTCAAGCTGAGGCAAA TTTCCTTTCAGACGGTCATTCCAGGGAACGAGTGGTTGTGTGGGGGAAATCAGGCCACTGGCTGTGAATA TCCCTCTATCCTGGTCTTGAATTGTGATTATCTATGTCCACTTCTGTCTCCTTCACTGTACTTGGAATTG ATCTGGTCATTCAGCTGGAAATGGGGGAAGATTTTGTCAAATTCTTGAGACACAGCTGGGTCTGGATCAG CGTAAGCTGCTCTGGTTTTATTGAACAGATGAAATCACATTTTTTTTTTCAAAATCAAAGAAATCTTATA GAGTTAACAGTGGACTCTTATAATAAGAGTTAACACCAGGACTCTTATTCTTGATTCTTTTCTGAGACAC CAAAATGAGATTTCTCAATGCCACCCTAATTCTTTTTTTTTTTTTTTTTTTTTTTGAGACACAGTCTGGG TCTTTTGCTCTGTCACTCAGGCTGGAGCGCAGTGGTGTGATCATAGCTCACTGAACCCTTGACCTCCTGG ACTTAAGGGATCCTCCTGCTTCAGCCTCCTGAGTAGATGGGGCTACAGGTGCTTGCCACCACACCTGGCT AATTAAATTTTTTTTTTTTTTTTGTAGAGAAAGGGTCTCACTTTGTTGCCCTGGCTGATCTTGAACTTCT GACTTCAAGTGATTCTTCAGCCTTGGACTCCCAAAGCACTGGGATTGCTGGCATGAGCCACTCACCGTGC CTGGCTTGCAGCTTAATCTTGGAGTGTATAAACCTGGCTCCTGATAGCTAGACATTTCAGTGAGAAGGAG GCATTGGATTTTGCATGAGGACAATTCTGACCTAGGAGGGCAGGTCAACAGGAATCCCCGCTGTACCTGT ACGTTGTACAGGCATGGAGAATGAGGAGTGAGGAGCCACCGGAACCCCATATTGTTTAGTGGACATTGGA TTTTGAAATAATAGGGAACTTGGTCTGGGAGAGTCATATTTCTGGATTGGACAATATGTGGTATCACAAG GTTTTATGATGAGGGAGAAATGTATGTGGGGAACCATTTTCTGAGTGTGGAAGTGCAAGAATCAGAGAGT ACTGAATGCCAACGCTTCTATTTCAGGAACATGGTAAGTTGGAGGTCCAGCTTCTGGGCTCAGACGGGTA TAGGGACCAGGAAGTCTCACAATCCGATCATTCTGATATTTCAGGGCATATTAGGTTTGGGGTGCAAAGG AAGTACTTGGGACTTAGGCACATGAGACTTTGTATTGAAAATCAATGATTGGGGCTGGCCGTGGTGGCTC ACGCCTGTAATCTCATCACTTTGGGAGACCGAAGTGGGAGGATGGCTTGAGCCCAGGAGTTGGAGACCAG CCTAGGCAACATAGCCAGACCCTCTCTCTACAAAAAAATTAAAAATTAGCTGGATGTGGTGGTGCATGCT TGTGGTCTCAGCTATCCTGGAGGCTGAGACAGGAGAATCGGTTGAGTCTGGGAGTTCAAGGCTACAGGGA GCTGCGATCACGCCGCTGCACTCCAGCCTGGGAAACAGAGTGAGACTGTCTCAGAATTTTTTTAAAAAAG AATCAGTGATCATCCCAACCCCTGTTGCTGTTCATCCTGAGCCTGCCTTCTCTGGCTTTGTTCCCTAGAT CACATCTCCATGATCCATAGGCCCTGCCCAATCTGACCTCACACCGTGGGAATGCCTCCAGACTGATCTA GTATGTGTGGAACAGCAAGTGCTGGCTCTCCCTCCCCTTCCACAGCTCTGGGTGTGGGAGGGGGTTGTCC AGCCTCCAGCAGCATGGGGAGGGCCTTGGTCAGCATCTAGGTGCCAACAGGGCAAGGGCGGGGTCCTGGA GAATGAAGGCTTTATAGGGCTCCTCAGGGAGGCCCCCCAGCCCCAAACTCACCACCTGGCCGTGGACACC TGTGTCAGCATGTGGGACCTGGTTCTCTCCATCGCCTTGTCTGTGGGGTGCACTGGTGAGATTGGGGGGA TAAAGGAAGGGGGGCGGGTTCTGACTCTTATGCTGAAGCCCTTTTCCTCCCACCCAGTGCCCCAGCCTCG TCCCTTCAGCCCACAGTTCAGCCCAGACAATGTGCCCCTGACTCTTCCACATTGCAATAGTCCTCATGCC CACACTAGGTCCCCGCTCCCTCCCACTTACCTCAGACCTTTCTCTCCATTGCCCAGCCAAATCCCTGCTC CCAGCTGCTTTACTAAAGAGCAAGTTCCTGGGCATCTCTGTGTTTCTCTTTATGGGGTTCAAAACCTTTC AAGGACCTCTCTCCATGCCACTGGTTCCTTGGACCCTATCACTGGGCTGCCTCCTGAGCCCCTCAGTCCT ACCACAGTCTACTGACTTTTCCTATTCAGCTGTGAGCATTCAACCCTGTCCCCTGGACCTTGACACCTGG CTCCCCAACCCTGTCCCAGGAAACCCAGATTCCACCAGACACTTCCTTCTTCCCCCCGAGGCTATCTGGC CTGAGACAACAAATGCTGCCTCCCACCCTGAGTCTGGCACTGGGACTTTCAGAACTCCTCCTTCCCTGAC TCTTTGCCCCAGACCCGTCATTCAATGGCTAGCTTTTTCCATGGGAAAAACACGAGCACCCCCAACCACA ACGGCCAGTTCTCTGATTCCCTAAATCCGCACCCTTTTCAAAACCTCAAAAACAAAACAAAACAAAACAA AGCAAGAAACAACTCAGGCAGAACTGTTTGCTTAACCTTGGACATGGTAAACCATCCAAAACCTTCCTCT CCCAGCAACTAAACCTCTCCACTGGGCACTTATCCTTGGTTTCTGGAACCTCTTATTCTCTTAGAACCCA CAGCTGCCACCACAGTGTCCCTTCTCCCAGTGTAAGACCCCAAATCACTCCAAATGACCCAACCCCCAAC CCGATGCCTGCTTCAGATGTTTCCCATGTCCCCTACTCTGATCTCTGGGGTCAGCTCCGTTCTCAGAGCA TGAAGCCTCCCGACCTGGTCCAGCCACCAACCCGCTAACGCAGGGAATAGCTACAGAATTGCCAGCCCTC CCAGGACCCCTTGCTTGTGTCCTGGACTCCCAGTCCTGGTCCTCTGCCCCCATGTCTCTTCAAACCCACA GCTCAGCTCCCTCCCCTATCCAATTCTTTTGGGTCTGATCCCCCTGACCCAGCACCCCCTCCGCAGGTGC CGTGCCCCTCATCCAGTCTCGGATTGTGGGAGGCTGGGAGTGTGAGAAGCATTCCCAACCCTGGCAGGTG GCTGTGTACAGTCATGGATGGGCACACTGTGGGGGTGTCCTGGTGCACCCCCAGTGGGTGCTCACAGCTG CCCATTGCCTAAAGAAGTAAGTAGGACCCTGGGATCTGGGGAGGGAATGGCTGTGTCCCACAGGAATAAC AGCGGGATGCTTCCCCCAGGGTCACTTCTCAGGTGAGGCTTCAGACTAAAGGAGAGAGGGAAGGTCCTGG CCCAGGTCGCACCCGGAGGCAGAGCTGGGGCTGGACCACTCTCCCCATGGCTGCCTGGGTTTCTCTCTGT GTCTGATCTCGCTGTGTCTCTTGGTATCTGGCTCTGGTTGTGTCTGTATGACTGTGTTTTGGTCTCTATG TCCCTCTCTCTTTTCTGTCTCCCTGTGTCTGTGTCTCCCCCGTCTCTGTCTCTGGGTCTCTCTGTGGCCA TCTCTGTCACCGTGTGTCTCACCCTGCATCTCTTTGCCTGTCTTTCTCTCTGGGTCTCTGCCTCAGCCCT TCCTCATCACTACTGAACACACCCCGTGAGGGTGGGTGGGGAGCACCCAGAAAAAGGAAGGACTTTAAGC TCAATGTGTGTGCATGTGAGGGGGTGCCTGTCATTGCACAGCACTCTCTGCAGGACATCCCTCCACCCTG GGGAGACACAGGGAGGGCTGGTTTCAGCTGTAGCTGGGTGCACAATTGAGGAGGGAGGAAGGAGAAGGGG AAACAAGAAAGGAGGGGAAGGTGGCCGGGCACGGTGGCCCACGCCTGTAATCCCAGCACTTTGGGAGGCC GAGGTGGGTGGATCATCTGAGGTCAGGAGTTTGAAACCAGCCTGGCCAACATGGCAAAACCCCGTCTCTA CTAAAAATACAAAAAGTAGCCAGGCGTGGTGCTGCGCGCCTGTAATCCCAATTACTAGGGAGGCTGAGGC AGGAGAATCGCTTGAACCCGGGAGGGAGAGGTTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTG GGTGACAGAGCAAGACTCCATCTCAGAAAAAACAAACAAACAAACAAACAACAAAAAAAATCGAAAGGAG GGGAAGGGAGCTGGAGAGAGAAAGGGGGACGTGGCCCTGAGCTGTGGGCCGGGCCACCCGCCACTACAGA GCCCTCACTCCAGCCCCAGCTGCAGGTGAGCCACCCTCATGCCTCTCCTCCTCCCCCTGCTACTCCACAC TCCTCAGATGCCCCCGTGGCCTCCCTCCTTTTTCTCTCCCACACTGTATCACCCCTGGCTTCCTCTCTGC TGTTTCTCCTTCTCTCTCTGACTTCCCGCATCCTTTTCTCATTTGTCTATTTCTCACTCCCTTCCTGGTT CTGTTCTTTCTCCCTTCCTCTTCCCCATGTCTATTTCTTGCTGTCTCTGTCTCTTCTTTGCTCATCCTAA TTCTCACTGTTCTCCCTTCTGTTTTTGTCATTCCTCTGCCATTTTATGCTCTCTCTTTTCCACTTCGTTT CTTTCAGTTTCTGTCTCTGCCTCTCACATGATCACACTCCTGTTTTCTAACTCACTGTCTGTATTTCACC ACGACTATATCTCCCCGACCCCTGTGCTTTTCTCACTGTTTCTTTTTCTTCCCTTTGGAGTCTCCCTTAT CCTCCCCTGCCCCATCTACCTTTCCCCATTTTCTCTCTCCTCATGCATCCACCCCCTTCCTCCCCAGGAA TAGCCAGGTCTGGCTGGGTCGGCACAACCTGTTTGAGCCTGAAGACACAGGCCAGAGGGTCCCTGTCAGC CACAGCTTCCCACACCCGCTCTACAATATGAGCCTTCTGAAGCATCAAAGCCTTAGACCAGATGAAGACT CCAGCCATGACCTCATGCTGCTCCGCCTGTCAGAGCCTGCCAAGATCACAGATGTTGTGAAGGTCCTGGG CCTGCCCACCCAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGGCAGCATCGAACCAGAG GAGTGTACGCCTGGGCCAGATGGTGTAGCTGGGAGCCCAGATGCCTGGGTCTGAGGGAAGTGGGGCCAAA GAACCAGGTGGGGTCCGGCCACAGCCCAGTTTTTCTCTGACCCATAGTCTTGCGCCCCAGGAGTCTTCAG TGTGTGAGCCTCCATCTCCTGTCCAATGACATGTGTGCTAGAGCTTACTCTGAGAAGGTGACAGAGTTCA TGTTGTGTGCTGGGCTCTGGACAGGTGGTAAAGACACTTGTGGGGTGAGTCATCCCTACTCCCAACATCT GGAGGGGAAAGGTGAGTGAAGACCCTAATTCTGGGCTGCAATCTGAAAGCTAACCAGACATCTGCCTCCC CTGCTCCCCAGCTATAGCCACGCCCCCTCCCCATGCCTCATCTGCCGCCCTCCTTCCCCCTTCCCTGACT CCCTCAACACAAGAGGTGATTCTCACAGCATAATTCACCCATTCCTGTGTTGAGCACATGCTTACTGGGC ACCTGCTACGTGACCAGCATTGCCGTAGACCCTGGGAAGCAGCAGTGAACAGGTAGAGAGCAGCCTCTCC CTCCTGCAGCCCCCATGCTGGTGAGGGGCACTGGCAGGAACAGTGGACCCAACATGGAAATGCTGGAGGG TGTCAGGAAGTGATCGGGCTCTGGGGCAGGGAGGAGGGGTGGGGAGTGTCACTGGGAGGGGACATCCTGC AGAAGGTAGGAGTGAGCAAACACCCGCTGCAGGGGAGGGGAGAGCCCTGCGGCACCTGGGGGAGCAGAGG GAGCAGCACCTGCCCAGGCCTGGGAGGAGGGGCCGGGAGGGCGTGAGGAGGAGCGAGGGGGCTGCATGGC TGGAGTGAGGGATCAGGGGCAGGGCGCGAGATGGCCTCACACAGGGAAGAGAGGGCCCCTCCTGCAGGGC CTCACCTGGGCCACAGGAGGACACTGCTTTTCCTCTGA Download Select all
Length	5850
OMIM ID	176820
HGNC ID	HGNC:6364
Unigene ID	Hs.171995
Ensembl ID	-
PharmGKB ID	PA164741810

mRNA Information

mRNA ID	NM_001030047.1
Exon	join(1..87,1326..1485,3115..3401,3545..3681,4616..5850)
mRNA Sequence	>gi\|71834852\|ref\|NM_001030047.1\| Homo sapiens kallikrein related peptidase 3 (KLK3), transcript variant 3, mRNA AGCCCCAAGCTTACCACCTGCACCCGGAGAGCTGTGTCACCATGTGGGTCCCGGTTGTCTTCCTCACCCT GTCCGTGACGTGGATTGGTGCTGCACCCCTCATCCTGTCTCGGATTGTGGGAGGCTGGGAGTGCGAGAAG CATTCCCAACCCTGGCAGGTGCTTGTGGCCTCTCGTGGCAGGGCAGTCTGCGGCGGTGTTCTGGTGCACC CCCAGTGGGTCCTCACAGCTGCCCACTGCATCAGGAACAAAAGCGTGATCTTGCTGGGTCGGCACAGCCT GTTTCATCCTGAAGACACAGGCCAGGTATTTCAGGTCAGCCACAGCTTCCCACACCCGCTCTACGATATG AGCCTCCTGAAGAATCGATTCCTCAGGCCAGGTGATGACTCCAGCCACGACCTCATGCTGCTCCGCCTGT CAGAGCCTGCCGAGCTCACGGATGCTGTGAAGGTCATGGACCTGCCCACCCAGGAGCCAGCACTGGGGAC CACCTGCTACGCCTCAGGCTGGGGCAGCATTGAACCAGAGGAGTTCTTGACCCCAAAGAAACTTCAGTGT GTGGACCTCCATGTTATTTCCAATGACGTGTGTGCGCAAGTTCACCCTCAGAAGGTGACCAAGTTCATGC TGTGTGCTGGACGCTGGACAGGGGGCAAAAGCACCTGCTCGTGGGTCATTCTGATCACCGAACTGACCAT GCCAGCCCTGCCGATGGTCCTCCATGGCTCCCTAGTGCCCTGGAGAGGAGGTGTCTAGTCAGAGAGTAGT CCTGGAAGGTGGCCTCTGTGAGGAGCCACGGGGACAGCATCCTGCAGATGGTCCTGGCCCTTGTCCCACC GACCTGTCTACAAGGACTGTCCTCGTGGACCCTCCCCTCTGCACAGGAGCTGGACCCTGAAGTCCCTTCC CCACCGGCCAGGACTGGAGCCCCTACCCCTCTGTTGGAATCCCTGCCCACCTTCTTCTGGAAGTCGGCTC TGGAGACATTTCTCTCTTCTTCCAAAGCTGGGAACTGCTATCTGTTATCTGCCTGTCCAGGTCTGAAAGA TAGGATTGCCCAGGCAGAAACTGGGACTGACCTATCTCACTCTCTCCCTGCTTTTACCCTTAGGGTGATT CTGGGGGCCCACTTGTCTGTAATGGTGTGCTTCAAGGTATCACGTCATGGGGCAGTGAACCATGTGCCCT GCCCGAAAGGCCTTCCCTGTACACCAAGGTGGTGCATTACCGGAAGTGGATCAAGGACACCATCGTGGCC AACCCCTGAGCACCCCTATCAACCCCCTATTGTAGTAAACTTGGAACCTTGGAAATGACCAGGCCAAGAC TCAAGCCTCCCCAGTTCTACTGACCTTTGTCCTTAGGTGTGAGGTCCAGGGTTGCTAGGAAAAGAAATCA GCAGACACAGGTGTAGACCAGAGTGTTTCTTAAATGGTGTAATTTTGTCCTCTCTGTGTCCTGGGGAATA CTGGCCATGCCTGGAGACATATCACTCAATTTCTCTGAGGACACAGATAGGATGGGGTGTCTGTGTTATT TGTGGGGTACAGAGATGAAAGAGGGGTGGGATCCACACTGAGAGAGTGGAGAGTGACATGTGCTGGACAC TGTCCATGAAGCACTGAGCAGAAGCTGGAGGCACAACGCACCAGACACTCACAGCAAGGATGGAGCTGAA AACATAACCCACTCTGTCCTGGAGGCACTGGGAAGCCTAGAGAAGGCTGTGAGCCAAGGAGGGAGGGTCT TCCTTTGGCATGGGATGGGGATGAAGTAAGGAGAGGGACTGGACCCCCTGGAAGCTGATTCACTATGGGG GGAGGTGTATTGAAGTCCTCCAGACAACCCTCAGATTTGATGATTTCCTAGTAGAACTCACAGAAATAAA GAGCTGTTATACTGTG Download Select all
Length	1906

CDS Information

Location	42..758
CDS Sequence	>lcl\|NM_001030047.1_cds_NP_001025218.1_1 [gene=KLK3] [protein=prostate-specific antigen isoform 3 preproprotein] [protein_id=NP_001025218.1] [location=42..758] ATGTGGGTCCCGGTTGTCTTCCTCACCCTGTCCGTGACGTGGATTGGTGCTGCACCCCTCATCCTGTCTC GGATTGTGGGAGGCTGGGAGTGCGAGAAGCATTCCCAACCCTGGCAGGTGCTTGTGGCCTCTCGTGGCAG GGCAGTCTGCGGCGGTGTTCTGGTGCACCCCCAGTGGGTCCTCACAGCTGCCCACTGCATCAGGAACAAA AGCGTGATCTTGCTGGGTCGGCACAGCCTGTTTCATCCTGAAGACACAGGCCAGGTATTTCAGGTCAGCC ACAGCTTCCCACACCCGCTCTACGATATGAGCCTCCTGAAGAATCGATTCCTCAGGCCAGGTGATGACTC CAGCCACGACCTCATGCTGCTCCGCCTGTCAGAGCCTGCCGAGCTCACGGATGCTGTGAAGGTCATGGAC CTGCCCACCCAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGGCAGCATTGAACCAGAGG AGTTCTTGACCCCAAAGAAACTTCAGTGTGTGGACCTCCATGTTATTTCCAATGACGTGTGTGCGCAAGT TCACCCTCAGAAGGTGACCAAGTTCATGCTGTGTGCTGGACGCTGGACAGGGGGCAAAAGCACCTGCTCG TGGGTCATTCTGATCACCGAACTGACCATGCCAGCCCTGCCGATGGTCCTCCATGGCTCCCTAGTGCCCT GGAGAGGAGGTGTCTAG Download Select all
CCDS ID	CCDS12807.1

Protein Information

Protein ID	NP_001025218.1
Protein Name	kallikrein-related peptidase 3
Molecular Wt. (Da)	0
Protein Sequence	>lcl\|NM_001030047.1_prot_NP_001025218.1_1 [gene=KLK3] [protein=prostate-specific antigen isoform 3 preproprotein] [protein_id=NP_001025218.1] [location=42..758] MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNK SVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHDLMLLRLSEPAELTDAVKVMD LPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVISNDVCAQVHPQKVTKFMLCAGRWTGGKSTCS WVILITELTMPALPMVLHGSLVPWRGGV Download Select all
Length	238
Uniprot ID	Q16819
Ensembl Protein ID	ENSP00000230588

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
K	Proteolytic Cleavage	169
N	Glycosylation	69
H	Proteolytic Cleavage	78
F	Proteolytic Cleavage	81
T	Phosphorylation	143
T	Phosphorylation	167
T	Phosphorylation	143
T	Phosphorylation	167
T	Phosphorylation	100
T	Phosphorylation	124

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
2	A2M	72	NP_000005.2	in vitro	8583572
12	SERPINA3	120	NP_001076.2	in vitro;in vivo	11 317 942 107 594 700 000 000
2057	EPOR	587	NP_000112.1	in vitro;in vivo	10374881
2335	FN1	626	NP_997647.1	in vitro	9016396
3486	IGFBP3	899	NP_001013416.1	in vitro	102 185 887 538 844
5265	SERPINA1	2463	NP_000286.3	in vitro	11317942
5340	PLG	1417	NP_000292.1	in vitro	10604721
5744	PTHLH	1348	NP_945316.1	in vitro	87 537 518 683 730
6406	SEMG1	1641	NP_002998.1	in vitro	110 274 129 092 810
6407	SEMG2	1642	NP_002999.1	in vitro	11027412
6590	SLPI	121	NP_003055.1	in vitro	7539415

Pathway Information

Pathway Name	Pathway ID
Pathways in cancer	hsa05200
Prostate cancer	hsa05215

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00190	25-256	Tryp_SPc
cl21584	25-256	Tryp_SPc superfamily
smart00020	24-253	Tryp_SPc
pfam00089	25-253	Trypsin
COG5640	6-255	COG5640

Ontology Information

HPRD ID	1280
Molecular Class	Serine protease
Molecular Function	Transmembrane receptor protein tyrosine kinase activity (GO:0004714)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO