Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FAS | 355 | Fas (TNF receptor superfamily, member 6) | 10 | APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22461695 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Down-regulation | - | Epigenetic inhibitors decitabine and vorinostat cooperate to upregulate Fas expression and suppress colon carcinoma metastasis. Altered expression of Fas, BNIP3, Bik, and Bcl-x(L) resulted in effective sensitization of the metastatic human colon carcinoma cells to FasL-induced apoptosis. |
| 22474491 | 2012 | Cell line : HCT 116, SW 480, HT 29, A 549, H 1299 Source : Food Industry Research and Development Institute (Hsinchu, Taiwan) Sample Type : - No. of Sample : - Stage : - | TUNEL assay and DNA gel electrophoresis | Down-regulation | - | Emilia sonchifolia (L.) DC (Compositae), an herbaceous plant found in Taiwan and India, is used as folk medicine and induced apoptosis both intrinsic and extrinsic pathway.
Methanolic Emilia sonchifolia Extract (ESE) was provided by Dr. YuHsuan Lan (School of Pharmacy, China Medical University). |
| 22669972 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Down-regulation | - | Fas functions as a suppressor of spontaneous sarcoma and colon carcinoma.
|
| 22997602 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Mutation | - | Due to microsatellite instability mutaion occurs in Fas gene. |
| 22753716 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : - Stage : - | - | Mutation & Down-regulation | - | Authors found a significant reduction in the levels of FAS and another lipogenic enzyme, LPL, in adipose tissue adjacent to tumor lesions, compared to the levels of FAS detected in paired tissue distant from neoplasia in patients with colorectal cancer. Authors also were detected that the serum levels of FAS in patients with colorectal cancer are associated with tumor stage. |
| 22199270 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 81 Stage : TNM Stage I-IV | RT-PCR | Unknown | - | - |
| 22508480 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Motility assay, immunofluorescence, RT-PCR and immunoblotting | Unknown | - | Fas signaling may induce epithelial-mesenchymal transition (EMT) to promote metastasis. Fas signaling downregulated epithelial markers, upregulated mesenchymal markers and promoted motility in gastrointestinal (GI) cancer cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Tumor necrosis factor receptor superfamily,CD molecules |
| Description | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011] |
| Chromosome | 10 |
| Location | 10q24.1 |
| Start | 88969801 |
| End | 89017059 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 47259 |
| OMIM ID | 134637 |
| HGNC ID | HGNC:11920 |
| Unigene ID | Hs.244139 |
| Ensembl ID | ENSG00000026103 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001141945.1 |
|---|---|
| Exon | complement(21139..21590) | mRNA Sequence | Download Select all |
| Length | 2755 |
CDS Information
| Location | join(13132..13212,19669..19779,33229..33394,37900..38037, 39089..39197,40739..40800,40953..41015,42199..42281, 43543..43567,44319..44650) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | XP_006717882.1 |
|---|---|
| Protein Name | Fas (TNF receptor superfamily, member 6) |
| Molecular Wt. (Da) | 40363 |
| Protein Sequence | Download Select all |
| Length | 362 |
| Uniprot ID | P35318 |
| Ensembl Protein ID | ENSP00000278175 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Palmitoylation | 199 |
| C | Palmitoylation | 178 |
| C | Palmitoylation | 199 |
| S | Phosphorylation | 209 |
| T | Phosphorylation | 214 |
| S | Phosphorylation | 188 |
| T | Phosphorylation | 193 |
| S | Phosphorylation | 212 |
| S | Phosphorylation | 191 |
| T | Phosphorylation | 219 |
| T | Phosphorylation | 198 |
Enzyme Information
| EC | 2.3.1.85 |
|---|---|
| Name | fatty-acid synthase FASN |
| Class | Transferases; Acyltransferases; Transferring groups other than aminoacyl groups |
| Sysname | acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) |
| Substrate | acetyl-CoA [CPD:C00024]; malonyl-CoA [CPD:C00083]; NADPH [CPD:C00005]; H+ |
| Product | long-chain fatty acid [CPD:C00638]; CoA [CPD:C00010]; CO2 [CPD:C00011]; NADP+ |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 317 | APAF1 | 3755 | NP_863651.1 | in vivo | 9267021 |
| 801 | CALM1 | 241 | NP_008819.1 | in vitro;in vivo | 14594800 |
| 1400 | CRMP1 | 3913 | NP_001014809.1 | yeast 2-hybrid | 16169070 |
| 4233 | MET | 1280 | NP_001120972.1 | in vitro;in vivo | 15911745 |
| 5578 | PRKCA | 1498 | NP_002728.1 | in vitro | 12586732 |
| 5777 | PTPN6 | 1475 | NP_536859.1 | in vitro;in vivo | 11786908 |
| 5906 | RAP1A | 1545 | NP_002875.1 | in vivo | 15207703 |
| 7430 | EZR | 475 | NP_003370.2 | in vitro;in vivo | 1 467 620 317 159 900 |
| 11161 | C14orf1 | 5201 | NP_009107.1 | yeast 2-hybrid | 16169070 |
| 55791 | C1orf103 | 17975 | NP_060842.3 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| African trypanosomiasis | hsa05143 |
| Allograft rejection | hsa05330 |
| Alzheimer's disease | hsa05010 |
| Apoptosis | hsa04210 |
| Autoimmune thyroid disease | hsa05320 |
| Chagas disease (American trypanosomiasis) | hsa05142 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Graft-versus-host disease | hsa05332 |
| Hepatitis B | hsa05161 |
| Herpes simplex infection | hsa05168 |
| Influenza A | hsa05164 |
| MAPK signaling pathway | hsa04010 |
| Measles | hsa05162 |
| Natural killer cell mediated cytotoxicity | hsa04650 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
| p53 signaling pathway | hsa04115 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| TNF signaling pathway | hsa04668 |
| Type I diabetes mellitus | hsa04940 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd10579 | 39-167 | TNFRSF6 |
| cl22855 | 39-167 | TNFRSF superfamily |
| cd08316 | 226-319 | Death_FAS_TNFRSF6 |
| cl14633 | 226-319 | DD superfamily |
| cd08784 | 232-311 | Death_DRs |
| smart00005 | 225-312 | DEATH |
| cd00185 | 59-147 | TNFRSF |
| cd13416 | 59-167 | TNFRSF16 |
| cd15835 | 50-165 | TNFRSF1B_teleost |
| cd10580 | 59-165 | TNFRSF10 |
| pfam00531 | 231-314 | Death |
| cd13423 | 54-149 | TNFRSF6_teleost |
| cd15834 | 58-166 | TNFRSF1A_teleost |
| cd15837 | 58-165 | TNFRSF26 |
| cd13405 | 55-143 | TNFRSF14_teleost |
| cd13407 | 54-173 | TNFRSF5 |
| cd10578 | 57-152 | TNFRSF3 |
| cd10577 | 57-166 | TNFRSF1B |
| cd13422 | 55-173 | TNFRSF5_teleost |
| cd10576 | 52-165 | TNFRSF1A |
| cd13420 | 56-149 | TNFRSF25 |
| cd13408 | 56-145 | TNFRSF7 |
| cd15836 | 54-167 | TNFRSF11A_teleost |
| cd13406 | 56-131 | TNFRSF4 |
| cd10575 | 59-165 | TNFRSF6B |
| cd01670 | 246-311 | Death |
| cd10581 | 42-173 | TNFRSF11B |
| cd10582 | 56-146 | TNFRSF14 |
| cd13424 | 56-152 | TNFRSF9_teleost |
| cd08306 | 246-314 | Death_FADD |
| cd15839 | 54-166 | TNFRSF_viral |
| pfam00020 | 129-165 | TNFR_c6 |
| cd13412 | 61-140 | TNFRSF11B_teleost |
| cd08313 | 243-311 | Death_TNFR1 |
| smart00208 | 129-165 | TNFR |
| cd13416 | 63-127 | TNFRSF16 |
| cd08317 | 253-302 | Death_ank |
| smart00208 | 85-127 | TNFR |
| cd13410 | 82-145 | TNFRSF9 |
| cd10583 | 59-166 | TNFRSF21 |
| pfam00020 | 85-127 | TNFR_c6 |
| cd13411 | 59-152 | TNFRSF11A |
| cd08315 | 246-316 | Death_TRAILR_DR4_DR5 |
Ontology Information
| HPRD ID | 61 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Peptide hormone (GO:0005180) |
| Biological Process | Regulation of physiological process (GO:0050791) |
Drug Information
No matching records could be found.