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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IL1B | 3553 | interleukin 1, beta | 2 | IL1F2, IL-1B, IL1-BETA |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24194923 | 2013 | Cell line : - Source : - Sample Type : Nested case-cohort study No. of Sample : 970 CRC cases and 1789 healthy control Stage : - | Genotyping | Up-regulation/ polymorphism | - | Genetically determined low COX-2 and high IL-1? activity were associated with increased risk of CRC in this northern Caucasian cohort. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interleukins and interleukin receptors, "Endogenous ligands" |
| Description | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008] |
| Chromosome | 2 |
| Location | 2q14 |
| Start | 113587337 |
| End | 113594356 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 7020 |
| OMIM ID | 147720 |
| HGNC ID | HGNC:5992 |
| Unigene ID | Hs.126256 |
| Ensembl ID | ENSG00000125538 |
| PharmGKB ID | PA29808 |
mRNA Information
| mRNA ID | XM_006712496.1 |
|---|---|
| Exon | join(536..597,1163..1214,3205..3663,3954..4118,5358..5488, 6207..7029) | mRNA Sequence | Download Select all |
| Length | 1692 |
Protein Information
| Protein ID | XP_006712559.1 |
|---|---|
| Protein Name | interleukin 1, beta |
| Molecular Wt. (Da) | 21640 |
| Protein Sequence | Download Select all |
| Length | 191 |
| Uniprot ID | Q96FS4 |
| Ensembl Protein ID | ENSP00000377771 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| E | Proteolytic Cleavage | 141 |
| D | Proteolytic Cleavage | 27 |
| D | Proteolytic Cleavage | 116 |
| D | Proteolytic Cleavage | 27 |
| D | Proteolytic Cleavage | 116 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2 | A2M | 72 | NP_000005.2 | in vitro;in vivo | 97 141 812 466 831 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| African trypanosomiasis | hsa05143 |
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Alzheimer's disease | hsa05010 |
| Amoebiasis | hsa05146 |
| Apoptosis | hsa04210 |
| Chagas disease (American trypanosomiasis) | hsa05142 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Cytosolic DNA-sensing pathway | hsa04623 |
| Graft-versus-host disease | hsa05332 |
| Hematopoietic cell lineage | hsa04640 |
| Herpes simplex infection | hsa05168 |
| Inflammatory bowel disease (IBD) | hsa05321 |
| Inflammatory mediator regulation of TRP channels | hsa04750 |
| Influenza A | hsa05164 |
| Legionellosis | hsa05134 |
| Leishmaniasis | hsa05140 |
| Malaria | hsa05144 |
| MAPK signaling pathway | hsa04010 |
| Measles | hsa05162 |
| NF-kappa B signaling pathway | hsa04064 |
| NOD-like receptor signaling pathway | hsa04621 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
| Osteoclast differentiation | hsa04380 |
| Pertussis | hsa05133 |
| Prion diseases | hsa05020 |
| Rheumatoid arthritis | hsa05323 |
| Salmonella infection | hsa05132 |
| TNF signaling pathway | hsa04668 |
| Toll-like receptor signaling pathway | hsa04620 |
| Tuberculosis | hsa05152 |
| Type I diabetes mellitus | hsa04940 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00100 | 123-265 | IL1 |
| cl00094 | 123-265 | IL1 superfamily |
| smart00125 | 119-265 | IL1 |
| pfam00340 | 147-264 | IL1 |
| pfam02394 | 1-103 | IL1_propep |
| cl03569 | 1-103 | IL1_propep superfamily |
| PHA02651 | 141-261 | PHA02651 |
Ontology Information
| HPRD ID | 3125 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P01584 | DB01017 | Minocycline | SmallMoleculeDrug |
| P01584 | DB05260 | Gallium nitrate | SmallMoleculeDrug |
| P01584 | DB06168 | Canakinumab | BiotechDrug |
| P01584 | DB06372 | Rilonacept | BiotechDrug |