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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IL1RN | 3557 | interleukin 1 receptor antagonist | 2 | IL1RA, ICIL-1RA, IL1F3, IRAP, IL-1RN, MGC10430 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18987561 | 2009 | Cell line : - Source : University of Southern California medical facilities. Sample Type : Blood samples No. of Sample : 109 CRC stage II Stage : TNM Stage II | PCR-RFLP | Polymorhpism | - | Polymorphisms in IL1B, IL1RN, and VEGFA as well as IL1B/IL1RN haplotype analysis may serve as molecular markers for tumor recurrence in stage II colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interleukins and interleukin receptors, "Endogenous ligands" |
| Description | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016] |
| Chromosome | 2 |
| Location | 2q14.2 |
| Start | 113868693 |
| End | 113891593 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 22901 |
| OMIM ID | 147679 |
| HGNC ID | HGNC:6000 |
| Unigene ID | Hs.81134 |
| Ensembl ID | ENSG00000136689 |
| PharmGKB ID | PA29816 |
mRNA Information
| mRNA ID | XM_011511121.1 |
|---|---|
| Exon | join(1..225,11752..11835,13636..13750,20702..20764, 22084..22254,28325..28376,30212..30300,31681..31793, 33292..34652) | mRNA Sequence | Download Select all |
| Length | 2273 |
Protein Information
| Protein ID | XP_011509423.1 |
|---|---|
| Protein Name | interleukin 1 receptor antagonist |
| Molecular Wt. (Da) | 16011 |
| Protein Sequence | Download Select all |
| Length | 143 |
| Uniprot ID | Q15475 |
| Ensembl Protein ID | ENSP00000247182 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00100 | 37-174 | IL1 |
| cl00094 | 37-174 | IL1 superfamily |
| smart00125 | 34-174 | IL1 |
| pfam00340 | 60-173 | IL1 |
| PHA02651 | 31-176 | PHA02651 |
Ontology Information
| HPRD ID | 1271 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P18510 | DB06372 | Rilonacept | BiotechDrug |