CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
22022540	2011	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Promoter reporter assays,	Polymorhpism	-	A transcription motif search revealed that the FasL promoter possessed two consensus T-cell factor (TCF/LEF1) binding elements (TBEs), which is either polymorphic (SNP -205C>G) or close to the functional SNP 844C>T. FasL is a target gene of the bcatenin/ T-cell factor pathway. Beta-catenin may be involved in FasL gene regulation and that FasL expression is influenced by FasL SNP haplotypes.

Gene Details

Chromosome: 1; NC_000001.10 (172628185..172636013)
View Larger Image

Gene Type	protein coding
Gene Family	Tumor necrosis factor (ligand) superfamily, CD molecules
Description	The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
Chromosome	1
Location	1q23
Start	172659008
End	172666873
Strand	+
Gene Sequence	>gi\|568815597:172659008-172666873 Homo sapiens chromosome 1, GRCh38.p2 Primary Assembly AGAATCAGAGAGAGAGAGATAGAGAAAGAGAAAGACAGAGGTGTTTCCCTTAGCTATGGAAACTCTATAA GAGAGATCCAGCTTGCCTCCTCTTGAGCAGTCAGCAACAGGGTCCCGTCCTTGACACCTCAGCCTCTACA GGACTGAGAAGAAGTAAAACCGTTTGCTGGGGCTGGCCTGACTCACCAGCTGCCATGCAGCAGCCCTTCA ATTACCCATATCCCCAGATCTACTGGGTGGACAGCAGTGCCAGCTCTCCCTGGGCCCCTCCAGGCACAGT TCTTCCCTGTCCAACCTCTGTGCCCAGAAGGCCTGGTCAAAGGAGGCCACCACCACCACCGCCACCGCCA CCACTACCACCTCCGCCGCCGCCGCCACCACTGCCTCCACTACCGCTGCCACCCCTGAAGAAGAGAGGGA ACCACAGCACAGGCCTGTGTCTCCTTGTGATGTTTTTCATGGTTCTGGTTGCCTTGGTAGGATTGGGCCT GGGGATGTTTCAGCTCTTCCACCTACAGAAGGAGCTGGCAGAACTCCGAGAGGTAAGCCTGCCGGCAGAC TGCTGTGCCCTGGAGGCACCAGGCATAAGGGGATGGAGGGCCCACTGCCTGGCTTGCAAAGTGCTTTTCA ATCCTTTTTTTTTTTTTCTTAGAAATGGGTTGTTCTAGTTATTCTATTCTATAGACAGAGAAATGGAGGC TCATAGGGGTGAAGGGAATATTTTTTACTTTGTAAAGAATCAGAGCCCAACAGTTTGTCTTTCCTCAGTT GTCAACTCAGTCTGTTGAACCACTTACTGCCTCATACCTATTGATTTAAGGAGTAAAAAACAAACAAACA AAACTTTTAAGTTTTGCTTGGAAGTAAATTTGTTCAGATGACCAAACTAAATCTTGAAAATTGGTACGAT TCCAAATCACAAAACTGAGGGACAGTGAGGCAAAATTGCTTGGCCAAAGCCCAAGTTAGCAGAACTTCTG AGGTATTTGGATTCTCTTTCCAGGGCTTGGTTTATTTGACGATTCTGCCTCTTTTGCTTAAAGAATTTTA TTTTTATTATACATCTTTTCTCTTTCTGTTTTACTAGTCTACCAGCCAGATGCACACAGCATCATCTTTG GAGAAGCAAATAGGTGAGTCTTTTTTCGCATGTACATTGAGTTCCCAAAGATGATCCTCAGCACAGAACT ATGTTAATGGAATGCCTTAAATTCTGTCCCACACTTTGGTTTCTGTACACTATAAGAGGAATTCTGGCTA ATTCAGAATCTCTGGTCTATGATTCCTTGAGCTGCTTTAAAAATGTGAAGTGAATTGAATTGCTCACAAT CAATATAGCTGAGCACTGCACACAATTCAAAATCACTTCCACTTGACTTTGGAAAGAGACACACATATAC AACCCTGGACCTTTGCCCCCTGAGAAGTGGCTCCAGGCCTGTCCCCTTCCACAGACATCCTGGTCCTGGC ACACACGCCAGTGGCTGTAACTCCTGGGAAGAGAAGGCGAAATGAAGGCAGAGACAGATGTTTCTGAGAA ACGTCCTTTCCTCTTTTAAATGCCCTAAAGAGATTACATTGAAGCTTTATTTACAATATGTTTTATAGGA TGTAAGCTTTTAAAACATGGATAATCAATTCCCCACATTAGAATGGTTTTTCTTGAAGTCACTGAGAAGC TTAAGGGAAGACTTCAGCCATCATTCAAAGGATGTTCAGCTTCACCCACAGAGGCAGTCATGAGGTACCC TTGATCACAAAGGAAAATCCTTTGTATGGGAGCTAGGGCAAGAAGATGATAGGTTGAACACTGATCTCAT GAAATTTCAGGGCATAGTTGTGCAAGCTCTGTACAGATAGATTTTACAGTGTGCTTCACTAGTCTAAGAT TCATTGAAATTTTAGATTTAGATTTACAATGAGATTCATTGAATTTTTAGAGGTGGAAGGAAGCTTAGAA TATATCTAGTCCAGCCATTTCATTTTTTGGAAGAGAAACAAAATACCAGATGGATTAGGTGAATATGCCC AAGACCACTGGTATGCCATTGGGGCTAGAAGGAACACAGGCTCTTGATGCCTTGTCACCTACAGGGCTTT CCAGTACTGGACTGGTGCCTCATGAAGGAGGGAAACTCCTGTCTCTCTGTAGTGAGCATGGAATAAGAAA TAGATGAAAAGCAGGATACCTCTGCAAAGACTATAGGTAGATCTCATCCTTAGAAACTCAGAATAAAGAA GAAGGCAGCACTGGCCATCTATTAAGTGAAGCAAGTTCCAGTTTCTCCGGATGTGGCTACTGCACATGAC CCAGTCGCCTGTCTACTATCCTAGACTGTTAAGTTCTTATATGAGCCACTGTTGGGATGCTCTGGCCCCT GCTTCTGTGTCCTAATCCTTAAATGTTAGAAAGTCCATATGTACACAAGCAGAGTGGAAATATTTGATAG AAAAGTAAAGCCTCTGGAGGACGTCTGAAATAAGATCATTTTGAAAATCTGTGGAATGTGCCTGGTCTGA TAGGTATCTAATTATTCATCTTTCACCCACTCTCTGGAGTCAATTTAGTGATTAAAAGTCAAATGATCAG GTGAGTCAGATCCATCTACCCCAGTAAGCAATTATGTTCTCTAGATCAACCCAAATAAACCAGAAATTGG TAAATCATCACATGGAAATCAAATCAGTAACTTTACTAATAAGAAAAGAGATGCAAATTAAAAATAGGGA ATACCAATTTTCATCAAATTAATAAAGATTAAAAAAAAACCCAGACTGACAAAGATTTGAGAGAAAAGTG CCTGTGCAAACATTAGTTTCAGCCAGTATACATGTAAATTGCTATAACTTTTTTTGAAGAGCGCTTTAGA AATACATAGCAAAAGCTTGTAACTAGTAGTTTACGTTGTAATCCTATCGCTAAGAATTTATCTTAAGAAA ATAATCAGAGATGTGCCCGAAGATTTATATATAAGGATGTTCATTACTTCCTTATGAGCCTATTTATAAT AAATAATTCAGAAGAAACTTGAATGCCTCATACGAGATTAGTTATATACATTATGGTGTATTCAGACAAG CACATAATAAGCAGCAACTAAAAGTGATGTATCAGAAGGACATTTAATGCTTTGGGGATTGTGCACTCTG TATTGTTAGATAAAAAGACAAGTTACAAAAGGGTATGTTTAGTTTCATACTGACTATGTAACCATGTATG CACATTTTTATATTCTTAGGAACTGGAAAGTTTTACACACTGACATACTAACAGTGATTTTCTCTGGGAG ATACTATTATAGATTATTTATACTTTCTAATTTGCTCCTTTTTACATTTTCCATTTTTTTCCGGTTAACT AATTAAATCTTTTATTCATTCACATGTGTGAGGCTAGATGTTGGGTGTTGGATGCTGATTGAGGATGAGC CAGCCCAGGGGGCCTGTCCTTATGGAGCTTTTAGCAGGGGGAAGAAGCTAAACAAAAGCAAGCAAACAGA CCATGCAATTCCAAAGTTGTACTAAGTACAACCTGAGAATCTTCTTTAAGGAGGTGTTGTTTACGCTAAC ACCTTGGGGGTCAGAAGCCCGATGAGTGAACGGCTGTGTGCATGTGCTGTGGAGTGGGGTGGGGCTGGGG GCGGGCATTTCAGCGCTGGGAACGGCACATGCAAAAACCCTGGGGCAGGAAGCACTCATAACCAGTGTCT AGGATATCCTTGCAATTTATTTATTCCAGTATAGGTACAGCAGATATTCTTAGTGAGCATGTTCTGTAAG AATAACGTTGTACTAGGCTCTGTGAGGGATATAAAGACATGCAACATGTGGTTCTCTGTTCCGTTTCCTG CCGGTGCGTGGCTGAGTGCCAGATTAGTTGCTCGGGTGGTTTGCGGTGTAGGAATGCAGAGGAGACTCAG TTTTGCCTTTCCTGTTCGCTAACACCTCCTACATGGTGGGTTGTCTTGGATGACTAGAGAGGTCATGATT GCTCAGCTAATGTTCTCTGTGGATTGGGCCATTCTCATACCATATGTGAGTTTTACAGGCTAATCACGAA CCTGACATAGACAAGCATCTCCTGTGAATATTTATTGAAGTCTCAGTTAGCTGAATTCATTAGCTAAGTG GCAGCTGTCTATCTTGTCTGAAACAGTTGAAGTCAGAGAAATAGTGTCTGTTTTGAGAACTATTGTCTAT CCTTCCATTTAATTTGTCCAACATTTGCTAGTAACATGCCCTGTGTTAGAAACTGGGCTTCTCTGGTGAA CTCAACGTATCGTAAGGAACTTGTCGTTATTTGAGGGGAATAAGATAATTTATGTAGTTACCCCAGAGAC AAGAGGAGTCAGAAATGACAAGAGAGGGGAAGACAGAGGGATCCTAGATTTCAAAAGAGGGGCAGATCAT ATTTGATCAAAAAAGGCTTGAGAGGGTTTCCCAAAGAAAGCGGTAATAGGTAGTCCTTATGGGATGTTTA GGAATTTGACACAGAAATCTGCTTGAAAGAACATTACGGGCAGAAGACATGGCATGAACAAAGGCACAGA GGAAGGAAAGTGGGGGTATGTGTAGGCCACAGAACTCCCGTTGTGTGGCAATGCTCAGTGGGAGTAAGGA GATAAGGCTGGACAGATGGGCTGGGATTGTGTGATGGGGATACTTGTATACGACGGCATCTTCGGGGAGG AGCAATTAAAGGTGTTTGAGGACTCAGTGATATGAGGTGATTGTCAGAGGTCTTAAGATAATTAATTTGG GGCAGATTGTAAAATGTCACTGGGGGAAGATCTGGTGACACGCAGACAGATCAGTAGTCTTCTTCAGCCT CTGTCCTGTAAGTCTTTGGAACAAGAGAATCAGAGTGGACAGAGCCCTGGAATTGGCGTCAGGAGAGCAG GGTGTGGTCCCATCTGTGATGCTGACTAGCTGGGTCTTCTTGGATTAGTCACCCAACTTCTAAGCTCATT TTGCAATCGATAAGGTGGGACAATAATACCTACCTCAAAGGGTTGTGGTGAGTTCTAAATGCAATAACTG ACATGACAGCTCTTTATGAATAAATGTTTATATTAATTATGTTTTATTGTAACATTATAATTTATACATA TGTCAATCTTAATTTGGTTTATTTTTTTACCTCTTTGTTTCTGAAATATAGACTACTATGAATCCTGCAG TTCAGACCTACATGATTAGTATATGTTAGACTGTTGCCATTTACGGTTTTAAAATCTTTTTTTTAAAATG ATTGGATTTAAATTCCCACCAAAATAATAGTTGCTATTTCATTTTAACATATATTTTTCCTCTCTCTATG ATACAGGCCACCCCAGTCCACCCCCTGAAAAAAAGGAGCTGAGGAAAGTGGCCCATTTAACAGGTCTGTA TCTGGAAGGTACAGGTGAGATTTGGGAAAGCTTTTGGCAAAAGGCAAAATGGCTGCCTGGTTTCCATTAC CAGGCTCTAGAGAGTTGTTACTTCCTGGAGACAGTATTTGAACCCAATAATACTAACACTTTTCTTGTCG AGTCAGTCTTATGAACACACTTTGATCCCCTATTCTCTGGGCAAGGCCCTCTTCTAAATTGGAGACCTGG AGCTGATTATGACATGACCCCTGCCCATAAGAAGCTCATTCTTTTCAGTCATTCCAAAGTCCCTTGGGGG ATTGGGGGCACAGATCCAAGAGGTGAGAGATGAGAAGGTGAGGAATGAGGACTTATTTTAGTCAGTGCTT TCTTGGTTTTCTGGAAGAGCTTCACTCTGCTTTGTCCAAGAGTATAAATAGGAGTGAGAAGGGAGACTCA ATCCTGGCACTTGTAGAGTTTCAATATGTGCCTGTAAAGTGGAGTGAAATGATATGGTATGGGCACTCCC ATTATAAACTACATAAATAATGGAATAAATATCACAGAAAGTGGTAGGCTATTGTCCCTGGAATTATTTA GGCAGAAATTATAGAATGATCCGGTCACATCAGCAGACACTTACTGAATACCTGCTGTGTGCCAATTTGG GGATGTGAAGATGAGTAGCACATGGCTCTTGCCCCCAGGGAGCTTGACATCTAATAGGGAAAGACAGGCA CTTATGATAATTTCAGTACTTCAGAGATTTAGGTTATGTTCATGATGTTGTGGGGATACAAAGAAAAGGG AACTGTACCCCAAATTGAGGGGCTGAATAATTCTTACTGCAGGTGAGAAGATGGACCAGATGGTCCCTAA GATCCTTCCCAACTTTAGAACTTTAGAGTTCCTTGGATTTGGCTTTTTCCTTCAGGAAAGGACTTCAAAG CCTAGCAGATTTGGTGCTAGTTCTGAAGATAGTAAAATCTTTGTTCCAGAGAGCAAATATTTTCTCAATA ATTTCTTACTGCAATGGATTACGGGTATATACTATTGTTCCAATTGTGTGGATGACAAAATAGGACAACG TTGTTGAGGAAATTCTGTGATGGATCAAGTTCTGACCCCTCAGCCAGTTCTATACCAGCTGTCATTCTGG GTGAAACATTTGTTGAAGGAAGGGCCCACAGTTTTGCCTTAGAAACTTAGTTTGTTGGATGCATGACTAT TCCTTGTTGAAAGCTCCTTTTGGATTTATTTCAGGCAAGTCCAACTCAAGGTCCATGCCTCTGGAATGGG AAGACACCTATGGAATTGTCCTGCTTTCTGGAGTGAAGTATAAGAAGGGTGGCCTTGTGATCAATGAAAC TGGGCTGTACTTTGTATATTCCAAAGTATACTTCCGGGGTCAATCTTGCAACAACCTGCCCCTGAGCCAC AAGGTCTACATGAGGAACTCTAAGTATCCCCAGGATCTGGTGATGATGGAGGGGAAGATGATGAGCTACT GCACTACTGGGCAGATGTGGGCCCGCAGCAGCTACCTGGGGGCAGTGTTCAATCTTACCAGTGCTGATCA TTTATATGTCAACGTATCTGAGCTCTCTCTGGTCAATTTTGAGGAATCTCAGACGTTTTTCGGCTTATAT AAGCTCTAAGAGAAGCACTTTGGGATTCTTTCCATTATGATTCTTTGTTACAGGCACCGAGAATGTTGTA TTCAGTGAGGGTCTTCTTACATGCATTTGAGGTCAAGTAAGAAGACATGAACCAAGTGGACCTTGAGACC ACAGGGTTCAAAATGTCTGTAGCTCCTCAACTCACCTAATGTTTATGAGCCAGACAAATGGAGGAATATG ACGGAAGAACATAGAACTCTGGGCTGCCATGTGAAGAGGGAGAAGCATGAAAAAGCAGCTACCAGGTGTT CTACACTCATCTTAGTGCCTGAGAGTATTTAGGCAGATTGAAAAGGACACCTTTTAACTCACCTCTCAAG GTGGGCCTTGCTACCTCAAGGGGGACTGTCTTTCAGATACATGGTTGTGACCTGAGGATTTAAGGGATGG AAAAGGAAGACTAGAGGCTTGCATAATAAGCTAAAGAGGCTGAAAGAGGCCAATGCCCCACTGGCAGCAT CTTCACTTCTAAATGCATATCCTGAGCCATCGGTGAAACTAACAGATAAGCAAGAGAGATGTTTTGGGGA CTCATTTCATTCCTAACACAGCATGTGTATTTCCAGTGCAATTGTAGGGGTGTGTGTGTGTGTGTGTGTG TGTGTGTGTGTATGACTAAAGAGAGAATGTAGATATTGTGAAGTACATATTAGGAAAATATGGGTTGCAT TTGGTCAAGATTTTGAATGCTTCCTGACAATCAACTCTAATAGTGCTTAAAAATCATTGATTGTCAGCTA CTAATGATGTTTTCCTATAATATAATAAATATTTATGTAGATGTGCATTTTTGTGAAATGAAAACATGTA ATAAAAAGTATATGTTAGGATACAAA Download Select all
Length	7866
OMIM ID	134638
HGNC ID	HGNC:11936
Unigene ID	Hs.2007
Ensembl ID	ENSG00000117560
PharmGKB ID	PA56

mRNA Information

mRNA ID	NM_000639.2
Exon	join(1..542,1088..1133,5327..5383,6615..7866)
mRNA Sequence	>356 GAGGTGTTTCCCTTAGCTATGGAAACTCTATAAGAGAGATCCAGCTTGCCTCCTCTTGAGCAGT CAGCAACAGGGTCCCGTCCTTGACACCTCAGCCTCTACAGGACTGAGAAGAAGTAAAACCGTTT GCTGGGGCTGGCCTGACTCACCAGCTGCCATGCAGCAGCCCTTCAATTACCCATATCCCCAGAT CTACTGGGTGGACAGCAGTGCCAGCTCTCCCTGGGCCCCTCCAGGCACAGTTCTTCCCTGTCCA ACCTCTGTGCCCAGAAGGCCTGGTCAAAGGAGGCCACCACCACCACCGCCACCGCCACCACTAC CACCTCCGCCGCCGCCGCCACCACTGCCTCCACTACCGCTGCCACCCCTGAAGAAGAGAGGGAA CCACAGCACAGGCCTGTGTCTCCTTGTGATGTTTTTCATGGTTCTGGTTGCCTTGGTAGGATTG GGCCTGGGGATGTTTCAGCTCTTCCACCTACAGAAGGAGCTGGCAGAACTCCGAGAGTCTACCA GCCAGATGCACACAGCATCATCTTTGGAGAAGCAAATAGGCCACCCCAGTCCACCCCCTGAAAA AAAGGAGCTGAGGAAAGTGGCCCATTTAACAGGCAAGTCCAACTCAAGGTCCATGCCTCTGGAA TGGGAAGACACCTATGGAATTGTCCTGCTTTCTGGAGTGAAGTATAAGAAGGGTGGCCTTGTGA TCAATGAAACTGGGCTGTACTTTGTATATTCCAAAGTATACTTCCGGGGTCAATCTTGCAACAA CCTGCCCCTGAGCCACAAGGTCTACATGAGGAACTCTAAGTATCCCCAGGATCTGGTGATGATG GAGGGGAAGATGATGAGCTACTGCACTACTGGGCAGATGTGGGCCCGCAGCAGCTACCTGGGGG CAGTGTTCAATCTTACCAGTGCTGATCATTTATATGTCAACGTATCTGAGCTCTCTCTGGTCAA TTTTGAGGAATCTCAGACGTTTTTCGGCTTATATAAGCTCTAAGAGAAGCACTTTGGGATTCTT TCCATTATGATTCTTTGTTACAGGCACCGAGAATGTTGTATTCAGTGAGGGTCTTCTTACATGC ATTTGAGGTCAAGTAAGAAGACATGAACCAAGTGGACCTTGAGACCACAGGGTTCAAAATGTCT GTAGCTCCTCAACTCACCTAATGTTTATGAGCCAGACAAATGGAGGAATATGACGGAAGAACAT AGAACTCTGGGCTGCCATGTGAAGAGGGAGAAGCATGAAAAAGCAGCTACCAGGTGTTCTACAC TCATCTTAGTGCCTGAGAGTATTTAGGCAGATTGAAAAGGACACCTTTTAACTCACCTCTCAAG GTGGGCCTTGCTACCTCAAGGGGGACTGTCTTTCAGATACATGGTTGTGACCTGAGGATTTAAG GGATGGAAAAGGAAGACTAGAGGCTTGCATAATAAGCTAAAGAGGCTGAAAGAGGCCAATGCCC CACTGGCAGCATCTTCACTTCTAAATGCATATCCTGAGCCATCGGTGAAACTAACAGATAAGCA AGAGAGATGTTTTGGGGACTCATTTCATTCCTAACACAGCATGTGTATTTCCAGTGCAATTGTA GGGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGACTAAAGAGAGAATGTAGATATTGTG AAGTACATATTAGGAAAATATGGGTTGCATTTGGTCAAGATTTTGAATGCTTCCTGACAATCAA CTCTAATAGTGCTTAAAAATCATTGATTGTCAGCTACTAATGATGTTTTCCTATAATATAATAA ATATTTATGTAGATGTGCATTTTTGTGAAATGAAAACATGTAATAAAAAGTATATGTTAGGATA CAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA Download Select all
Length	1909

CDS Information

Location	join(195..542,1088..1133,5327..5383,6615..7009)
CDS Sequence	>gi\|4557328:158-1003 Homo sapiens Fas ligand (TNF superfamily, member 6) (FASLG), mRNA ATGCAGCAGCCCTTCAATTACCCATATCCCCAGATCTACTGGGTGGACAGCAGTGCCAGCTCTCCCTGGG CCCCTCCAGGCACAGTTCTTCCCTGTCCAACCTCTGTGCCCAGAAGGCCTGGTCAAAGGAGGCCACCACC ACCACCGCCACCGCCACCACTACCACCTCCGCCGCCGCCGCCACCACTGCCTCCACTACCGCTGCCACCC CTGAAGAAGAGAGGGAACCACAGCACAGGCCTGTGTCTCCTTGTGATGTTTTTCATGGTTCTGGTTGCCT TGGTAGGATTGGGCCTGGGGATGTTTCAGCTCTTCCACCTACAGAAGGAGCTGGCAGAACTCCGAGAGTC TACCAGCCAGATGCACACAGCATCATCTTTGGAGAAGCAAATAGGCCACCCCAGTCCACCCCCTGAAAAA AAGGAGCTGAGGAAAGTGGCCCATTTAACAGGCAAGTCCAACTCAAGGTCCATGCCTCTGGAATGGGAAG ACACCTATGGAATTGTCCTGCTTTCTGGAGTGAAGTATAAGAAGGGTGGCCTTGTGATCAATGAAACTGG GCTGTACTTTGTATATTCCAAAGTATACTTCCGGGGTCAATCTTGCAACAACCTGCCCCTGAGCCACAAG GTCTACATGAGGAACTCTAAGTATCCCCAGGATCTGGTGATGATGGAGGGGAAGATGATGAGCTACTGCA CTACTGGGCAGATGTGGGCCCGCAGCAGCTACCTGGGGGCAGTGTTCAATCTTACCAGTGCTGATCATTT ATATGTCAACGTATCTGAGCTCTCTCTGGTCAATTTTGAGGAATCTCAGACGTTTTTCGGCTTATATAAG CTCTAA Download Select all
CCDS ID	CCDS1304.1

Protein Information

Protein ID	NP_000630.1
Protein Name	Fas ligand (TNF superfamily, member 6)
Molecular Wt. (Da)	31354
Protein Sequence	>356 MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPPPPLP PLPLPPLKKRGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLE KQIGHPSPPPEKKELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVY SKVYFRGQSCNNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADH LYVNVSELSLVNFEESQTFFGLYKL Download Select all
Length	281
Uniprot ID	P29275
Ensembl Protein ID	ENSP00000304501

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
N	Glycosylation	184
N	Glycosylation	250
N	Glycosylation	260

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
355	FAS	609	NP_000034.1	in vitro;in vivo	92 280 589 126 929
2885	GRB2	150	NP_002077.1	in vitro;in vivo	117 415 991 202 301 000 000 000
5300	PIN1	3031	NP_006212.1	in vivo	11741599
7430	EZR	475	NP_003370.2	in vitro;in vivo	11013215
9051	PSTPIP1	5891	NP_003969.2	in vitro;in vivo;yeast 2-hybrid	16204241
23048	FNBP1	10446	NP_055848.1	in vivo	12023017

Pathway Information

Pathway Name	Pathway ID
African trypanosomiasis	hsa05143
Allograft rejection	hsa05330
Apoptosis	hsa04210
Autoimmune thyroid disease	hsa05320
Chagas disease (American trypanosomiasis)	hsa05142
Cytokine-cytokine receptor interaction	hsa04060
FoxO signaling pathway	hsa04068
Graft-versus-host disease	hsa05332
Hepatitis B	hsa05161
Herpes simplex infection	hsa05168
Influenza A	hsa05164
MAPK signaling pathway	hsa04010
Measles	hsa05162
Natural killer cell mediated cytotoxicity	hsa04650
Neurotrophin signaling pathway	hsa04722
Non-alcoholic fatty liver disease (NAFLD)	hsa04932
Pathways in cancer	hsa05200
PI3K-Akt signaling pathway	hsa04151
Proteoglycans in cancer	hsa05205
Ras signaling pathway	hsa04014
Type I diabetes mellitus	hsa04940

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00184	146-279	TNF
cl00147	146-279	TNF superfamily
smart00207	160-281	TNF
pfam00229	160-281	TNF

Ontology Information

HPRD ID	15971
Molecular Class	Ligand
Molecular Function	G-protein coupled receptor activity (GO:0004930)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report