Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20176658 | 2010 | Cell line : HCT116, HT29, DLD 1, SW480, SW620, Caco2 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Western blotting,real time RT-PCR | Up-regulation | - | IL4Ralpha, a component of the IL4R and IL13R, contributes to tumor formation in a mouse model of colitis-associated cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interleukins and interleukin receptors, "CD molecules" |
| Description | This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012] |
| Chromosome | 16 |
| Location | 16p12.1-p1 |
| Start | 27325161 |
| End | 27376099 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 50939 |
| OMIM ID | 147781 |
| HGNC ID | HGNC:6015 |
| Unigene ID | Hs.513457 |
| Ensembl ID | ENSG00000077238 |
| PharmGKB ID | PA29832 |
mRNA Information
| mRNA ID | XM_011545825.1 |
|---|---|
| Exon | join(1..150,26519..26606,28454..28592,31202..31353, 32800..32951,38873..39029,42141..42240,45249..45327, 47099..47148,48585..51111) | mRNA Sequence | Download Select all |
| Length | 3594 |
Protein Information
| Protein ID | XP_011544127.1 |
|---|---|
| Protein Name | interleukin 4 receptor |
| Molecular Wt. (Da) | 89528 |
| Protein Sequence | Download Select all |
| Length | 825 |
| Uniprot ID | P12755 |
| Ensembl Protein ID | ENSP00000367797 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 497 |
| Y | Phosphorylation | 575 |
| Y | Phosphorylation | 603 |
| Y | Phosphorylation | 631 |
| Y | Phosphorylation | 713 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3565 | IL4 | 989 | NP_000580.1 | in vitro;in vivo | 11786020 |
| 3596 | IL13 | 981 | NP_002179.2 | in vivo | 11709756 |
| 3667 | IRS1 | 943 | NP_005535.1 | in vivo | 8599766 |
| 3717 | JAK2 | 993 | NP_004963.1 | in vivo | 8609418 |
| 5590 | PRKCZ | 1504 | NP_002735.3 | in vitro;in vivo | 15526032 |
| 6778 | STAT6 | 3302 | NP_003144.3 | in vitro | 15661890 |
| 9046 | DOK2 | 5411 | NP_003965.2 | in vitro | 10856136 |
| 9655 | SOCS5 | 6159 | NP_054730.1 | in vitro | 12242343 |
| 10425 | ARIH2 | 9286 | NP_006312.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Hematopoietic cell lineage | hsa04640 |
| Inflammatory bowel disease (IBD) | hsa05321 |
| Jak-STAT signaling pathway | hsa04630 |
| PI3K-Akt signaling pathway | hsa04151 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00063 | 123-219 | FN3 |
| cl21522 | 123-219 | FN3 superfamily |
| pfam09238 | 27-121 | IL4Ra_N |
| cl07754 | 27-121 | IL4Ra_N superfamily |
| smart00060 | 123-203 | FN3 |
| pfam00041 | 125-216 | fn3 |
| PHA03247 | 434-702 | PHA03247 |
| PHA03379 | 444-597 | PHA03379 |
Ontology Information
| HPRD ID | 3256 |
|---|---|
| Molecular Class | Cytokine receptor |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Regulation of cell cycle (GO:0000074) |
Drug Information
No matching records could be found.