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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21163075 | 2010 | Cell line : - Source : - Sample Type : Serum in colorectal carcinoma group and the control group. No. of Sample : - Stage : - | ELISA,immunoturbidimetry,Kaplan-Meier and Log-rank method | Up-regulation | - | The serum VEGF, IL-6, and CRP levels in colorectal carcinoma were higher than that in the control group. |
| 25333344 | 2014 | Cell line : HCT116, SW480 Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry | Up-regulation | - | The pro-inflammatory cytokine interleukin-6 (IL6) promotes colorectal cancer (CRC) development. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interleukins and interleukin receptors, "Interferons" |
| Description | This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| Chromosome | 7 |
| Location | 7p21-p15 |
| Start | 22766766 |
| End | 22771621 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4856 |
| OMIM ID | 147620 |
| HGNC ID | HGNC:6018 |
| Unigene ID | Hs.654458 |
| Ensembl ID | ENSG00000136244 |
| PharmGKB ID | PA198 |
mRNA Information
| mRNA ID | XM_011515390.1 |
|---|---|
| Exon | join(1..817,1738..1840,2003..2193,3252..3365,4073..4219, 5965..6561) | mRNA Sequence | Download Select all |
| Length | 1969 |
Protein Information
| Protein ID | XP_011513692.1 |
|---|---|
| Protein Name | interleukin 6 |
| Molecular Wt. (Da) | 23587 |
| Protein Sequence | Download Select all |
| Length | 212 |
| Uniprot ID | Q13309 |
| Ensembl Protein ID | ENSP00000274254 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Disulfide Bridge | 101;111 |
| T | Glycosylation | 166 |
| T | Glycosylation | 170 |
| T | Glycosylation | 171 |
| C | Disulfide Bridge | 72;78 |
| N | Glycosylation | 73 |
| S | Phosphorylation | 81 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6456 | SH3GL2 | 5125 | NP_003017.1 | yeast 2-hybrid | 16169070 |
| 7704 | ZBTB16 | 11762 | NP_005997.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| African trypanosomiasis | hsa05143 |
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Amoebiasis | hsa05146 |
| Chagas disease (American trypanosomiasis) | hsa05142 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Cytosolic DNA-sensing pathway | hsa04623 |
| FoxO signaling pathway | hsa04068 |
| Graft-versus-host disease | hsa05332 |
| Hematopoietic cell lineage | hsa04640 |
| Hepatitis B | hsa05161 |
| Herpes simplex infection | hsa05168 |
| HIF-1 signaling pathway | hsa04066 |
| HTLV-I infection | hsa05166 |
| Hypertrophic cardiomyopathy (HCM) | hsa05410 |
| Inflammatory bowel disease (IBD) | hsa05321 |
| Influenza A | hsa05164 |
| Insulin resistance | hsa04931 |
| Intestinal immune network for IgA production | hsa04672 |
| Jak-STAT signaling pathway | hsa04630 |
| Legionellosis | hsa05134 |
| Malaria | hsa05144 |
| Measles | hsa05162 |
| NOD-like receptor signaling pathway | hsa04621 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
| Pathways in cancer | hsa05200 |
| Pertussis | hsa05133 |
| PI3K-Akt signaling pathway | hsa04151 |
| Prion diseases | hsa05020 |
| Rheumatoid arthritis | hsa05323 |
| Salmonella infection | hsa05132 |
| TNF signaling pathway | hsa04668 |
| Toll-like receptor signaling pathway | hsa04620 |
| Transcriptional misregulation in cancer | hsa05202 |
| Tuberculosis | hsa05152 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00489 | 57-210 | IL6 |
| cl02473 | 57-210 | IL6 superfamily |
| smart00126 | 57-210 | IL6 |
Ontology Information
| HPRD ID | 173 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Auxiliary transport protein activity (GO:0015457) |
| Biological Process | Transport (GO:0006810) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P05231 | DB01404 | Ginseng | SmallMoleculeDrug |
| P05231 | DB09036 | Siltuximab | BiotechDrug |