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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CXCL8 | 3576 | chemokine (C-X-C motif) ligand 8 | 4 | SCYB8, LUCT, LECT, MDNCF, TSG-1, IL-8, NAP-1, 3-10C, MONAP, AMCF-I, LYNAP, NAF, b-ENAP, GCP-1, K60, GCP1, NAP1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19173296 | 2009 | Cell line : HCT116,HT29 Source : ATCC Sample Type : - No. of Sample : - Stage : - | real time RT-PCR,Western blotting ,Chromatin immunoprecipitation, Invasion assays, Immunohistochemisty | Up-regulation | - | CXCL8 was expressed in adenomatous polyps and adenocarcinomas. |
| 24657657 | 2014 | Cell line : - Source : - Sample Type : CRC Tumor No. of Sample : 213 Stage : - | - | Up-regulation | - | CCL20 and CXCL8 synergize to promote CRC metastatic progression by coordinated induction of EMT via PI3K/AKT-ERK1/2 signaling axis. |
| 25687885 | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : 186 Stage : - | - | Up-regulation | - | CXCL8 is strongly implicated in the resistance of CRC cells to anoikis, and that the AKT, TOPK and ERK pathway may be a potential therapeutic target for CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interleukins and interleukin receptors, "Endogenous ligands" |
| Description | The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008] |
| Chromosome | 4 |
| Location | 4q13-q21 |
| Start | 74606223 |
| End | 74609433 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3211 |
| OMIM ID | 146930 |
| HGNC ID | HGNC:6025 |
| Unigene ID | Hs.624 |
| Ensembl ID | ENSG00000169429 |
| PharmGKB ID | PA29841 |
mRNA Information
| mRNA ID | NM_000584.3 |
|---|---|
| Exon | join(1..217,1037..1172,1444..1527,1944..3211) | mRNA Sequence | Download Select all |
| Length | 1718 |
Protein Information
| Protein ID | NP_000575.1 |
|---|---|
| Protein Name | chemokine (C-X-C motif) ligand 8 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 99 |
| Uniprot ID | Q15758 |
| Ensembl Protein ID | ENSP00000397924 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| R | Proteolytic Cleavage | 27 |
| S | Proteolytic Cleavage | 28 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2532 | DARC | 192 | NP_001116423.1 | in vitro;in vivo | 992 141 217 416 748 |
| 2771 | GNAI2 | 764 | NP_002061.1 | in vivo | 8662698 |
| 3577 | CXCR1 | 908 | NP_000625.1 | in vitro;in vivo | 1840701 |
| 3579 | CXCR2 | 907 | NP_001548.1 | in vitro;in vivo | 946 456 787 027 988 000 000 |
| 5196 | PF4 | 1426 | NP_002610.1 | in vitro;in vivo | 1 553 176 312 586 630 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Amoebiasis | hsa05146 |
| Bladder cancer | hsa05219 |
| Chagas disease (American trypanosomiasis) | hsa05142 |
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Epithelial cell signaling in Helicobacter pylori infection | hsa05120 |
| Hepatitis B | hsa05161 |
| Hepatitis C | hsa05160 |
| Influenza A | hsa05164 |
| Legionellosis | hsa05134 |
| Malaria | hsa05144 |
| NF-kappa B signaling pathway | hsa04064 |
| NOD-like receptor signaling pathway | hsa04621 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
| Pathways in cancer | hsa05200 |
| Pertussis | hsa05133 |
| Phospholipase D signaling pathway | hsa04072 |
| Rheumatoid arthritis | hsa05323 |
| RIG-I-like receptor signaling pathway | hsa04622 |
| Salmonella infection | hsa05132 |
| Shigellosis | hsa05131 |
| Toll-like receptor signaling pathway | hsa04620 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00273 | 31-94 | Chemokine_CXC |
| cl00134 | 31-94 | Chemokine superfamily |
| cd00169 | 35-93 | Chemokine |
| pfam00048 | 28-91 | IL8 |
| smart00199 | 31-91 | SCY |
| cd00272 | 36-92 | Chemokine_CC |
| cd01119 | 36-89 | Chemokine_CC_DCCL |
| cd00274 | 61-86 | Chemokine_CX3C |
Ontology Information
| HPRD ID | 683 |
|---|---|
| Molecular Class | Not Available |
| Molecular Function | Auxiliary transport protein activity (GO:0015457) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.