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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CXCR2 | 3579 | chemokine (C-X-C motif) receptor 2 | 2 | CMKAR2, CD182 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26131180 | 2015 | Cell line : - Source : Gastrointestinal Surgery Department, in Subei Peoples Hospital. Sample Type : CRC tumor and normal tissue No. of Sample : 46 Stage : - | RT-PCR, two-step immunohistochemistry | Up-regulation | - | CXCR2 expression in CRC patients may be a potential molecular biomarker for evaluation of tumour growth and invasion. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "GPCR / Class A : Chemokine receptors : C-X-C motif", "Interleukins and interleukin receptors" |
| Description | The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009] |
| Chromosome | 2 |
| Location | 2q35 |
| Start | 218990013 |
| End | 219001976 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 11964 |
| OMIM ID | 146928 |
| HGNC ID | HGNC:6027 |
| Unigene ID | Hs.846 |
| Ensembl ID | ENSG00000180871 |
| PharmGKB ID | PA29843 |
mRNA Information
| mRNA ID | NM_001168298.1 |
|---|---|
| Exon | join(1..70,1002..1064,4025..4076,9488..11964) | mRNA Sequence | Download Select all |
| Length | 2672 |
Protein Information
| Protein ID | NP_001161770.1 |
|---|---|
| Protein Name | chemokine (C-X-C motif) receptor 2 |
| Molecular Wt. (Da) | 40628 |
| Protein Sequence | Download Select all |
| Length | 360 |
| Uniprot ID | P11166 |
| Ensembl Protein ID | ENSP00000416293 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 347 |
| S | Phosphorylation | 351 |
| S | Phosphorylation | 352 |
| S | Phosphorylation | 353 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 408 | ARRB1 | 146 | NP_004032.2 | in vivo | 11170396 |
| 2769 | GNA15 | 760 | NP_002059.2 | in vivo | 9843397 |
| 2773 | GNAI3 | 765 | NP_006487.1 | in vivo | 8316840 |
| 2890 | GRIA1 | 695 | NP_000818.2 | in vivo | 12888558 |
| 2920 | CXCL2 | 741 | NP_002080.1 | in vitro;in vivo | 87 027 989 260 277 |
| 2921 | CXCL3 | 742 | NP_002081.2 | in vivo | 8702798 |
| 3577 | CXCR1 | 908 | NP_000625.1 | in vivo | 15946947 |
| 4645 | MYO5B | 7582 | NP_001073936.1 | in vivo | 15004234 |
| 5515 | PPP2CA | 8912 | NP_002706.1 | in vitro;in vivo | 11278485 |
| 6372 | CXCL6 | 735 | NP_002984.1 | in vivo | 105 933 359 692 902 |
| 6767 | ST13 | 8426 | NP_003923.2 | in vivo | 11751889 |
| 9630 | GNA14 | 5095 | NP_004288.1 | in vivo | 8316840 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Endocytosis | hsa04144 |
| Epithelial cell signaling in Helicobacter pylori infection | hsa05120 |
| Phospholipase D signaling pathway | hsa04072 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00001 | 71-314 | 7tm_1 |
| PHA03087 | 23-321 | PHA03087 |
| PHA02834 | 49-322 | PHA02834 |
| PHA02638 | 50-329 | PHA02638 |
| PHA03235 | 119-321 | PHA03235 |
Ontology Information
| HPRD ID | 1148 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Auxiliary transport protein activity (GO:0015457) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.