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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 14581351 | 2003 | Cell line : - Source : Hiroshima University Hospital and the JR Hiroshima General Hospital of West Japan Railway Company. Sample Type : CRC tumor No. of Sample : 70 specimens from 70 patients with primary colon adenocarcinomas Stage : Duke Stage B,C | Immunohistochemistry,ELISA ,RT-PCR | Up-regulation | - | IL-15 produced by metastatic colon carcinoma cells can induce hyperplasia in the mucosa adjacent to colon cancer, thus contributing to angiogenesis and progression of the disease. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interleukins and interleukin receptors |
| Description | The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011] |
| Chromosome | 4 |
| Location | 4q31 |
| Start | 142557749 |
| End | 142655140 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 97392 |
| OMIM ID | 600554 |
| HGNC ID | HGNC:5977 |
| Unigene ID | Hs.168132 |
| Ensembl ID | ENSG00000164136 |
| PharmGKB ID | PA29790 |
mRNA Information
| mRNA ID | NM_172175.2 |
|---|---|
| Exon | join(1..153,19591..19712,52227..52440,82783..82881, 83874..83971,84464..84582,85329..85413,91345..91389, 93252..93389,96143..97392) | mRNA Sequence | Download Select all |
| Length | 2333 |
Protein Information
| Protein ID | NP_751915.1 |
|---|---|
| Protein Name | interleukin 15 |
| Molecular Wt. (Da) | 14781 |
| Protein Sequence | Download Select all |
| Length | 135 |
| Uniprot ID | O75751 |
| Ensembl Protein ID | ENSP00000275300 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3560 | IL2RB | 896 | NP_000869.1 | in vivo | 80 264 679 176 231 |
| 3561 | IL2RG | 2391 | NP_000197.1 | in vivo | 8568232 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Herpes simplex infection | hsa05168 |
| HTLV-I infection | hsa05166 |
| Intestinal immune network for IgA production | hsa04672 |
| Jak-STAT signaling pathway | hsa04630 |
| Rheumatoid arthritis | hsa05323 |
| TNF signaling pathway | hsa04668 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 121 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Protease inhibitor activity (GO:0030414) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.