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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
IL16 3603 interleukin 16  15LCF, IL-16, prIL-16, HsT19289, FLJ42735, FLJ16806 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19073878   2009Cell line : -

Source : West China Hospital, Sichuan University and were unrelated Chinese individuals residing in China

Sample Type : CRC tumor and normal tissues

No. of Sample : 596 cancer patients (376 patients with CRC and 220 patients with GC) and 480 non-cancer controls.

Stage : -

-Polymorhpism- IL-16 polymorphisms may contribute to CRC and GC susceptibility.


Gene Details



NC_000015.9 (81474941..81605104)

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Gene Type protein coding
Gene Family Interleukins and interleukin receptors
Description The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]  
Chromosome 15
Location 15q26.3
Start 81474941  
End 81605104  
Strand +  
Gene Sequence

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Length 130164  
OMIM ID 603035   
HGNC ID HGNC:5980   
Unigene ID Hs.459095   
Ensembl ID ENSG00000172349   
PharmGKB ID PA29793   

mRNA Information


mRNA ID XM_005254342.2
Exon join(1..297,42700..43112,77173..77281,83060..83202, 86939..87049,90491..90605,96218..96291,96959..97175, 100040..100157,103099..103231,107854..107941, 109957..110438,114329..114479,116781..117876, 118745..118913,120950..121051,123309..123567, 123821..123946,126006..126503)  
mRNA Sequence

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Length 4701  



CDS Information


   
Location258..4397
CDS Sequence

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CCDS ID CCDS10317.1



Protein Information


      
Protein IDXP_005254399.1
Protein Nameinterleukin 16
Molecular Wt. (Da)147012
Protein Sequence

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Length 1379  
Uniprot IDP03973
Ensembl Protein ID ENSP00000342082  



Post-translational Modification Information (Source : HPRD)


Residue Type site
DProteolytic Cleavage1211
DProteolytic Cleavage510
DProteolytic Cleavage1211
SPhosphorylation743
SPhosphorylation42
SPhosphorylation743
SPhosphorylation743
SPhosphorylation42
SPhosphorylation743
TPhosphorylation757
TPhosphorylation56
TPhosphorylation757
SPhosphorylation863
SPhosphorylation162
SPhosphorylation863
SPhosphorylation946
SPhosphorylation245
SPhosphorylation946
SPhosphorylation922
SPhosphorylation221
SPhosphorylation922
SPhosphorylation920
SPhosphorylation219
SPhosphorylation920

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                 
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
920CD41740NP_000607.1in vivo18   518   007   910   967   
2903GRIN2A698NP_000824.1in vivo;yeast 2-hybrid10479680   
2904GRIN2B697NP_000825.2yeast 2-hybrid10479680   
2905GRIN2C699NP_000826.2yeast 2-hybrid10479680   
2906GRIN2D4095NP_000827.2in vitro;yeast 2-hybrid10479680   
3750KCND12233NP_004970.3yeast 2-hybrid10479680   
3759KCNJ22815NP_000882.1in vivo;yeast 2-hybrid10479680   
3761KCNJ42738NP_690607.1yeast 2-hybrid10479680   
3766KCNJ103732NP_002232.2in vitro;yeast 2-hybrid10479680   
3772KCNJ153659NP_733932.1in vitro;yeast 2-hybrid10479680   
4659PPP1R12A3606NP_002471.1in vitro;in vivo;yeast 2-hybrid12923170   
10534SSSCA16921NP_006387.1yeast 2-hybrid16189514   
30008EFEMP25221NP_058634.3yeast 2-hybrid16189514   
63948DMRTB116828NP_149056.1yeast 2-hybrid16189514   
83878USHBP118276NP_114147.2yeast 2-hybrid16189514   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00992217-300  PDZ_signaling
cl00117217-300  PDZ superfamily
cd009921111-1188  PDZ_signaling
cl001171111-1188  PDZ superfamily
cd009921234-1317  PDZ_signaling
cl001171234-1317  PDZ superfamily
cd00992355-437  PDZ_signaling
cl00117355-437  PDZ superfamily
smart002281234-1320  PDZ
smart002281111-1188  PDZ
smart00228213-300  PDZ
pfam00595217-300  PDZ
smart00228352-439  PDZ
cd001361123-1197  PDZ
cd00136225-300  PDZ
pfam005951114-1188  PDZ
cd001361243-1317  PDZ
cd00136379-437  PDZ
cd009881242-1327  PDZ_CTP_protease
pfam005951234-1317  PDZ
cd009881122-1183  PDZ_CTP_protease
cd009891279-1319  PDZ_metalloprotease
cd00988261-300  PDZ_CTP_protease
PRK12438860-955  PRK12438
PHA03307761-940  PHA03307
TIGR002251236-1319  prc


Ontology Information


   
HPRD ID3689
Molecular ClassCytokine
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO