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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22539392 | 2012 | Cell line : - Source : Chinese population obtained from Department of Coloproctology, Youjiang Medical College for Nationalities, Guangxi Baise, China. Sample Type : CRC tumor and normal tissues No. of Sample : 170 CRC and 160 healthy controls Stage : - | PCR-RFLP | Polymorhpism | - | IL-18 gene -137G/C polymorphism and -137C/-607A haplotype are associated with CRC. -137C allele may be an important genetic susceptibility gene for CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interleukins and interleukin receptors |
| Description | The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011] |
| Chromosome | 11 |
| Location | 11q22.2-q2 |
| Start | 112013974 |
| End | 112034840 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 20867 |
| OMIM ID | 600953 |
| HGNC ID | HGNC:5986 |
| Unigene ID | Hs.83077 |
| Ensembl ID | ENSG00000150782 |
| PharmGKB ID | PA29802 |
mRNA Information
| mRNA ID | NM_001243211.1 |
|---|---|
| Exon | join(1..212,9057..9143,13912..14046,15382..15515, 20301..20867) | mRNA Sequence | Download Select all |
| Length | 1151 |
Protein Information
| Protein ID | NP_001230140.1 |
|---|---|
| Protein Name | interleukin 18 |
| Molecular Wt. (Da) | 21765 |
| Protein Sequence | Download Select all |
| Length | 189 |
| Uniprot ID | O43623 |
| Ensembl Protein ID | ENSP00000020945 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| D | Proteolytic Cleavage | 71 |
| D | Proteolytic Cleavage | 76 |
| D | Proteolytic Cleavage | 36 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| African trypanosomiasis | hsa05143 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Cytosolic DNA-sensing pathway | hsa04623 |
| Inflammatory bowel disease (IBD) | hsa05321 |
| Influenza A | hsa05164 |
| Legionellosis | hsa05134 |
| Malaria | hsa05144 |
| NOD-like receptor signaling pathway | hsa04621 |
| Rheumatoid arthritis | hsa05323 |
| Salmonella infection | hsa05132 |
| Tuberculosis | hsa05152 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00340 | 72-185 | IL1 |
| cl00094 | 72-185 | IL1 superfamily |
| smart00125 | 110-168 | IL1 |
Ontology Information
| HPRD ID | 4461 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.