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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
IMPDH2 3615 IMP (inosine 5'-monophosphate) dehydrogenase 2  3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19597826   2009Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

2-D Gel electrophoresis, Western blotting, matrix-assisted laser desorption ionization time-of-flight mass spectrometry,immunohistochemistryUp-regulation-IMPDH2 may be a protein biomarker and novel therapeutic target in CRC.

The expression of IMPDH2 in tumor tissue was significantly higher in patients with CRC than that in healthy subjects.


Gene Details



Chromosome 3 - NC_000003.12 (49024325..49029701, complement)

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Gene Type protein coding
Gene Family
Description This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.  
Chromosome 3
Location 3p21.2
Start 49024325  
End 49029701  
Strand -  
Gene Sequence

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Length 5377  
OMIM ID 146691   
HGNC ID HGNC:6053   
Unigene ID Hs.654400   
Ensembl ID ENSG00000178035   
PharmGKB ID -   

mRNA Information


mRNA ID XM_006713128.2
Exon join(1..449,896..944,1170..1271,1380..1454,1786..1992, 2655..2742,2816..3015,3093..3183,3283..3378,3636..3707, 4433..4576,4662..4806,4900..5043,5124..5207,5298..5377)  
mRNA Sequence

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Length 1712  



CDS Information


   
Location join(142..449,896..944,1170..1271,1380..1454,1786..1992, 2655..2742,2816..3015,3093..3183,3283..3378,3636..3707, 4433..4576,4662..4806,4900..5043,5124..5207,5298..5319)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_000875.2
Protein NameIMP (inosine 5'-monophosphate) dehydrogenase 2
Molecular Wt. (Da)55674
Protein Sequence

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Length 514  
Uniprot IDQ14526
Ensembl Protein ID ENSP00000314080  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation400;-
SPhosphorylation160;-
SPhosphorylation159;-
SPhosphorylation122
SPhosphorylation416
KAcetylation511
KAcetylation436
TPhosphorylation345
SPhosphorylation425
SPhosphorylation426

Enzyme Information


   
EC1.1.1.205
NameIMP dehydrogenase
inosine-5'-phosphate dehydrogenase
inosinic acid dehydrogenase
inosinate dehydrogenase
inosine 5'-monophosphate dehydrogenase
inosine monophosphate dehydrogenase
IMP oxidoreductase
inosine monophosphate oxidoreductase
ClassOxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor
SysnameIMP:NAD+ oxidoreductase  
SubstrateIMP [CPD:C00130]; NAD+ [CPD:C00003]; H2O [CPD:C00001]  
ProductXMP [CPD:C00655]; NADH [CPD:C00004]; H+ [CPD:C00080]  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
56893UBQLN45670NP_064516.2yeast 2-hybrid16713569   


Pathway Information


                  
Pathway Name Pathway ID
Drug metabolism - other enzymes hsa00983
Metabolic pathways hsa01100
Purine metabolism hsa00230


Structure Information


PDB ID1B3O
Resolution2.9
Method?? X-RAY DIFFRACTION
Chains A, B  
Molecule PROTEIN (INOSINE MONOPHOSPHATE DEHYDROGENASE 2)  
Model View



Domain Information




ID Location Description
cd0038129-480  IMPDH
cl2145729-480  TIM_phosphate_binding superfamily
cd04602115-230  CBS_pair_IMPDH_2
cl15354115-230  CBS_pair superfamily
cd04601115-229  CBS_pair_IMPDH
cd02205116-227  CBS_pair
cd04584116-227  CBS_pair_ACT_assoc
cd04730252-397  NPD_like
cd04612116-227  CBS_pair_SpoIVFB_EriC_assoc
cd04610116-227  CBS_pair_ParBc_assoc
cd04631116-227  CBS_pair_18
cd04637116-229  CBS_pair_24
cd04595116-227  CBS_pair_DHH_polyA_Pol_assoc
cd04803116-227  CBS_pair_15
cd04585116-227  CBS_pair_ACT_assoc2
cd04599117-227  CBS_pair_GGDEF_assoc2
cd04633116-227  CBS_pair_20
cd04622116-227  CBS_pair_9
cd04634117-227  CBS_pair_21
cd04586115-227  CBS_pair_BON_assoc
cd04600116-227  CBS_pair_HPP_assoc
cd04613116-227  CBS_pair_SpoIVFB_EriC_assoc2
smart00116184-231  CBS
cd04636116-227  CBS_pair_23
cd04609119-227  CBS_pair_PALP_assoc2
cd04635116-229  CBS_pair_22
cd04802151-227  CBS_pair_3
pfam00571175-229  CBS
cd04638116-227  CBS_pair_25
cd04801153-227  CBS_pair_M50_like
cd02809255-387  alpha_hydroxyacid_oxid_FMN
cd04722234-388  TIM_phosphate_binding
cd04605117-229  CBS_pair_MET2_assoc
cd04588116-227  CBS_pair_CAP-ED_DUF294_assoc_arch
cd04583151-227  CBS_pair_ABC_OpuCA_assoc2
cd04729261-388  NanE
cd04736261-410  MDH_FMN
cd04596115-230  CBS_pair_DRTGG_assoc
cd04606142-222  CBS_pair_Mg_transporter
cd04587116-227  CBS_pair_CAP-ED_DUF294_PBI_assoc
cd04737287-387  LOX_like_FMN
cd02811302-399  IDI-2_FMN
cd04629116-227  CBS_pair_16
smart00116117-164  CBS
cd04624118-227  CBS_pair_11
cd04639121-227  CBS_pair_26
cd04611116-230  CBS_pair_PAS_GGDEF_DUF1_assoc
cd04607153-227  CBS_pair_NTP_transferase_assoc
PRK01130261-388  PRK01130
cd04615142-229  CBS_pair_2
pfam00571115-163  CBS
cd00452261-385  KDPG_aldolase
cd04601193-237  CBS_pair_IMPDH
pfam00977266-390  His_biosynth
cd04800117-227  CBS_pair_CAP-ED_DUF294_PBI_assoc2
cd0459797-163  CBS_pair_DRTGG_assoc2
cd02808340-387  GltS_FMN
cd04623116-229  CBS_pair_10
cd04638183-232  CBS_pair_25
cd04590116-205  CBS_pair_CorC_HlyC_assoc
COG0800287-384  Eda
cd04642117-227  CBS_pair_29
pfam00977298-388  His_biosynth
TIGR03966304-396  actino_HemFlav
cd02803310-391  OYE_like_FMN_family
cd04621117-226  CBS_pair_8
cd04604118-227  CBS_pair_KpsF_GutQ_assoc
COG0167310-398  PyrD
cd04595188-229  CBS_pair_DHH_polyA_Pol_assoc
cd04612184-277  CBS_pair_SpoIVFB_EriC_assoc
cl15354184-277  CBS_pair superfamily
pfam04131260-390  NanE
cd04605183-229  CBS_pair_MET2_assoc
PRK07695287-392  PRK07695
cd04800116-163  CBS_pair_CAP-ED_DUF294_PBI_assoc2
cd04643127-229  CBS_pair_30
cd04621115-163  CBS_pair_8
PTZ0031416-510  PTZ00314
PLN0227415-514  PLN02274
pfam0047828-504  IMPDH
TIGR0130229-481  IMP_dehydrog
PRK0556729-504  PRK05567
PRK0710731-504  PRK07107
PRK0684328-508  PRK06843
TIGR0130330-476  IMP_DH_rel_1
PRK0780730-478  PRK07807
PRK05458241-416  PRK05458
TIGR01305236-479  GMP_reduct_1
PRK05096250-476  PRK05096
COG0516283-507  GuaB
TIGR01306183-484  GMP_reduct_2
PRK08649263-402  PRK08649
COG051629-118  GuaB
TIGR01304263-402  IMP_DH_rel_2
COG0517104-227  CBS
COG2070300-397  YrpB
COG2524117-227  COG2524
pfam03060304-397  NMO
pfam01070304-387  FMN_dh
PRK05437310-392  PRK05437
COG1304302-387  LldD
COG3448117-227  COG3448
TIGR02151302-397  IPP_isom_2
COG410964-230  YtoI
TIGR03151285-395  enACPred_II
COG3620119-229  COG3620
COG3448177-229  COG3448
PLN02535359-407  PLN02535
COG0517176-229  CBS


Ontology Information


   
HPRD ID826
Molecular ClassEnzyme: Dehydrogenase
Molecular FunctionMHC class I receptor activity (GO:0030106); MHC class II receptor activity (GO:0045012)
Biological ProcessImmune response (GO:0006955)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P12268DB00688Mycophenolate mofetilSmallMoleculeDrug
P12268DB01024Mycophenolic acidSmallMoleculeDrug
P12268DB01033MercaptopurineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO