Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ING1 | 3621 | inhibitor of growth family, member 1 | 13 | p33ING1, p33ING1b, p24ING1c, p33, p47, p47ING1a |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15694021 | 2005 | Cell line : - Source : - Sample Type : CRC tumor and adjescent tissue No. of Sample : 46 Stage : Duke stage A-D | PCR-SSCP,PCR-SSLP,RT-PCR | Down-regulation | - | ING1 down-regulation may happen in transcription or post-transcription, and correlates tightly with the occurrence and progression of sporadic colorectal cancer. |
| 16273637 | 2005 | Cell line : - Source : Department of Coloproctological Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi Province, China. Sample Type : CRC tumor No. of Sample : 35 Stage : - | PCR-SSCP,PCR-SSLP,RT-PCR | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, PHD-type |
| Description | This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| Chromosome | 13 |
| Location | 13q34 |
| Start | 111364970 |
| End | 111373421 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 8452 |
| OMIM ID | 601566 |
| HGNC ID | HGNC:6062 |
| Unigene ID | Hs.46700 |
| Ensembl ID | ENSG00000153487 |
| PharmGKB ID | PA29872 |
mRNA Information
| mRNA ID | XM_011521120.1 |
|---|---|
| Exon | complement(515..979) | mRNA Sequence | Download Select all |
| Length | 1883 |
Protein Information
| Protein ID | XP_011519422.1 |
|---|---|
| Protein Name | inhibitor of growth family, member 1 |
| Molecular Wt. (Da) | 33642 |
| Protein Sequence | Download Select all |
| Length | 302 |
| Uniprot ID | Q99835 |
| Ensembl Protein ID | ENSP00000249373 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 126 |
| Y | Phosphorylation | 44 |
| T | Phosphorylation | 318 |
| T | Phosphorylation | 131 |
| T | Phosphorylation | 106 |
| T | Phosphorylation | 175 |
| S | Phosphorylation | 342 |
| S | Phosphorylation | 155 |
| S | Phosphorylation | 130 |
| S | Phosphorylation | 199 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1728 | NQO1 | 518 | NP_000894.1 | in vivo | 18388957 |
| 2810 | SFN | 3185 | NP_006133.1 | in vitro | 16581770 |
| 3065 | HDAC1 | 3143 | NP_004955.2 | in vivo | 15451426 |
| 5111 | PCNA | 1456 | NP_002583.1 | in vitro;in vivo | 1 168 260 512 015 300 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro;in vivo | 122 087 369 440 695 |
| 7529 | YWHAB | 3184 | NP_003395.1 | in vitro | 16581770 |
| 7531 | YWHAE | 5457 | NP_006752.1 | in vitro | 16581770 |
| 7532 | YWHAG | 5639 | NP_036611.2 | in vitro | 16581770 |
| 7533 | YWHAH | 215 | NP_003396.1 | in vitro | 16581770 |
| 7534 | YWHAZ | 3183 | NP_003397.1 | in vitro | 16581770 |
| 10971 | YWHAQ | 886 | NP_006817.1 | in vitro | 16581770 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd15584 | 355-399 | PHD_ING1_2 |
| cl22851 | 355-399 | PHD_SF superfamily |
| cd15682 | 354-402 | PHD_ING1 |
| cd15505 | 355-399 | PHD_ING |
| cd15683 | 354-402 | PHD_ING2 |
| cd15585 | 355-399 | PHD_ING3 |
| cd15586 | 355-399 | PHD_ING4_5 |
| cd15587 | 355-399 | PHD_Yng1p_like |
| pfam12998 | 168-256 | ING |
| cl15229 | 168-256 | ING superfamily |
| cd15685 | 354-402 | PHD_ING5 |
| cd15684 | 354-399 | PHD_ING4 |
| pfam00628 | 355-400 | PHD |
| cd15553 | 355-399 | PHD_Cfp1 |
| smart00249 | 355-399 | PHD |
| cd15522 | 365-399 | PHD_TAF3 |
| cd15568 | 364-397 | PHD5_NSD |
| cd16039 | 355-399 | PHD_SPP1 |
| cd15518 | 355-399 | PHD_Ecm5p_Lid2p_like |
| cd15560 | 355-399 | PHD2_3_BPTF |
| cd15489 | 356-399 | PHD_SF |
| cd15661 | 355-397 | PHD5_NSD3 |
| cd15554 | 355-399 | PHD_PHF2_like |
| cd15552 | 355-399 | PHD_PHF3_like |
| cd15660 | 364-397 | PHD5_NSD2 |
| cd15606 | 355-399 | PHD2_KDM5A |
| cd15539 | 364-399 | PHD1_AIRE |
| cd15567 | 364-399 | PHD4_NSD |
| cd15517 | 367-399 | PHD_TCF19_like |
| COG5034 | 348-400 | TNG2 |
Ontology Information
| HPRD ID | 5025 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.