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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ING2 3622 inhibitor of growth family, member 2  4p33ING2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19437536   2009Cell line : -

Source : BD Bioscience (San Jose, CA) and Maryland University hospital.

Sample Type : CRC tumor

No. of Sample : 39

Stage : TNM stage I-IV.

 In situ hybridization,Immunohistochemistry,RT-PCR,western blotting, immunoprecipitation,EMSAUp-regulation-ING2 mRNA level in colon cancer tissue increased to more than twice than that in normal mucosa in the 45% of colorectal cancer cases .


Gene Details



NC_000004.11 (184426220..184433422)

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Gene Type protein coding
Gene Family Zinc fingers, PHD-type
Description This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]  
Chromosome 4
Location 4q35.1
Start 184426220  
End 184433422  
Strand +  
Gene Sequence

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Length 7203  
OMIM ID 604215   
HGNC ID HGNC:6063   
Unigene ID Hs.107153   
Ensembl ID ENSG00000168556   
PharmGKB ID PA29873   

mRNA Information


mRNA ID NM_001564.3
Exon join(1..318,5233..7379)  
mRNA Sequence

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Length 2465  



CDS Information


   
Location 147..989
CDS Sequence

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CCDS ID CCDS3833.1



Protein Information


      
Protein IDNP_001555.1
Protein Nameinhibitor of growth family, member 2
Molecular Wt. (Da)32677
Protein Sequence

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Length 280  
Uniprot IDO95863
Ensembl Protein ID ENSP00000244050  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation56

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4086SMAD13356NP_005891.1in vivo15761153   
57154SMURF16902NP_065162.1in vivo15761153   
64750SMURF26901NP_073576.1in vivo15761153   
121504HIST4H413662NP_778224.1in vivo16782091   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd15683213-261  PHD_ING2
cl22851213-261  PHD_SF superfamily
cd15584214-258  PHD_ING1_2
pfam1299827-125  ING
cl1522927-125  ING superfamily
cd15682213-261  PHD_ING1
cd15505214-258  PHD_ING
cd15586214-258  PHD_ING4_5
cd15585214-258  PHD_ING3
cd15685213-261  PHD_ING5
cd15587214-258  PHD_Yng1p_like
cd15684213-258  PHD_ING4
pfam00628214-259  PHD
cd15522224-258  PHD_TAF3
smart00249215-258  PHD
cd15568223-256  PHD5_NSD
cd15518214-258  PHD_Ecm5p_Lid2p_like
cd15553214-258  PHD_Cfp1
cd15661214-256  PHD5_NSD3
cd15660223-256  PHD5_NSD2
cd16039214-258  PHD_SPP1
cd15659223-256  PHD5_NSD1
cd15560214-258  PHD2_3_BPTF
cd15606214-258  PHD2_KDM5A
cd15489223-258  PHD_SF
cd15539223-258  PHD1_AIRE
cd15516214-258  PHD2_KDM5A_like
cd15552214-258  PHD_PHF3_like
cd15567223-258  PHD4_NSD
cd15543238-258  PHD_RSF1
COG503430-259  TNG2


Ontology Information


   
HPRD ID1227
Molecular ClassCell cycle control protein
Molecular FunctionChaperone activity (GO:0003754)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO