Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CXCL10 | 3627 | chemokine (C-X-C motif) ligand 10 | 4 | IFI10, IP-10, crg-2, mob-1, C7, gIP-10 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24748971 | 2014 | Cell line : - Source : Southeastern Sweden at the Department of Surgery, Ryhov County Hospital, Jnkping, Sweden. Sample Type : Blood samples No. of Sample : 366 Stage : Duke stage A-D | Quantification of CXCL10 protein,genotype determination | Up-regulation and polymorphism | - | Altered CXCL10 protein concentrations in CRC tissues or plasma and the rs8878 genotype variant of CXCL10 may contribute to the prediction of clinical outcome. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014] |
| Chromosome | 4 |
| Location | 4q21 |
| Start | 76942269 |
| End | 76944689 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 2421 |
| OMIM ID | 147310 |
| HGNC ID | HGNC:10637 |
| Unigene ID | Hs.632586 |
| Ensembl ID | - |
| PharmGKB ID | PA35568 |
mRNA Information
| mRNA ID | NM_001565.3 |
|---|---|
| Exon | join(1..166,720..846,1082..1171,1589..2421) | mRNA Sequence | Download Select all |
| Length | 1227 |
Protein Information
| Protein ID | NP_001556.2 |
|---|---|
| Protein Name | chemokine (C-X-C motif) ligand 10 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 98 |
| Uniprot ID | O76070 |
| Ensembl Protein ID | ENSP00000361087 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| P | Proteolytic Cleavage | 23 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1462 | VCAN | 340 | NP_004376.2 | in vitro | 11083865 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Cytosolic DNA-sensing pathway | hsa04623 |
| Influenza A | hsa05164 |
| RIG-I-like receptor signaling pathway | hsa04622 |
| TNF signaling pathway | hsa04668 |
| Toll-like receptor signaling pathway | hsa04620 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00273 | 27-91 | Chemokine_CXC |
| cl00134 | 27-91 | Chemokine superfamily |
| pfam00048 | 27-89 | IL8 |
| smart00199 | 29-87 | SCY |
| cd00169 | 31-87 | Chemokine |
Ontology Information
| HPRD ID | 4068 |
|---|---|
| Molecular Class | Chemokine |
| Molecular Function | Structural molecule activity (GO:0005198) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.