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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PDX1 | 3651 | pancreatic and duodenal homeobox 1 | 13 | IDX-1, STF-1, PDX-1, MODY4 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18855980 | 2008 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR, Western blotting, and immuno-histochemistry | Up-regulation | - | Lower levels of PDX-1 were found to be present in the primary tumor, while normal colon tissue failed to express detectable levels of PDX-1. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / ANTP class : HOXL subclass |
| Description | The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). |
| Chromosome | 13 |
| Location | 13q12.1 |
| Start | 27919994 |
| End | 27926314 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6321 |
| OMIM ID | 600733 |
| HGNC ID | HGNC:6107 |
| Unigene ID | Hs.32938 |
| Ensembl ID | ENSG00000139515 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_000209.3 |
|---|---|
| Exon | join(38..551,4263..6321) | mRNA Sequence | Download Select all |
| Length | 2573 |
CDS Information
| Location | join(146..551,4263..4708) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS9327.1 |
Protein Information
| Protein ID | NP_000200.1 |
|---|---|
| Protein Name | pancreatic and duodenal homeobox 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | Q16665 |
| Ensembl Protein ID | ENSP00000323326 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1385 | CREB1 | 442 | NP_604391.1 | in vivo | 7505393 |
| 3375 | IAPP | 1005 | NP_000406.1 | in vitro | 9115263 |
| 6514 | SLC2A2 | 685 | NP_000331.1 | in vivo | 8923459 |
| 6929 | TCF3 | 918 | NP_003191.1 | in vivo | 10636926 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Insulin secretion | hsa04911 |
| Maturity onset diabetes of the young | hsa04950 |
| Type II diabetes mellitus | hsa04930 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 147-205 | homeodomain |
| cl00084 | 147-205 | homeodomain superfamily |
| pfam00046 | 147-203 | Homeobox |
| smart00389 | 146-202 | HOX |
| COG5576 | 147-209 | COG5576 |
Ontology Information
| HPRD ID | 829 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | MHC class I receptor activity (GO:0030106); MHC class II receptor activity (GO:0045012) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.