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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ITGA6 | 3655 | integrin subunit alpha 6 | 2 | CD49f; VLA-6; ITGA6B |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23705994 | 2013 | Cell line : - Source : Department, Barretos Cancer Hospital, Brazil. Sample Type : CRC Tumor No. of Sample : 114 Stage : TNM stage I-IV | real time RT-PCR,tissue microarray | Up-regulation | - | In relation to TNM staging, ITGB5 and ITGA3 were over-expressed in stages III versus I. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Integrin subunits, alpha |
| Description | The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] |
| Chromosome | 2 |
| Location | 2q31.1 |
| Start | 173291954 |
| End | 173371181 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 79228 |
| OMIM ID | 147556 |
| HGNC ID | HGNC:6142 |
| Unigene ID | - |
| Ensembl ID | ENSG00000091409 |
| PharmGKB ID | - |
Protein Information
| Protein ID | |
|---|---|
| Protein Name | integrin subunit alpha 6 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | P18583 |
| Ensembl Protein ID | ENSP00000300278 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 1064 |
| S | Phosphorylation | 446 |
| T | Phosphorylation | 460 |
| S | Phosphorylation | 446 |
| T | Phosphorylation | 460 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 821 | CANX | 252 | NP_001737.1 | in vitro;in vivo | 8163531 |
| 977 | CD151 | 3763 | NP_004348.2 | in vivo | 10811835 |
| 1308 | COL17A1 | 223 | NP_000485.3 | in vivo;yeast 2-hybrid | 950 099 111 739 652 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vivo | 7556090 |
| 3688 | ITGB1 | 628 | NP_391987.1 | in vivo | 9425259 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | hsa05412 |
| Cell adhesion molecules (CAMs) | hsa04514 |
| Dilated cardiomyopathy | hsa05414 |
| ECM-receptor interaction | hsa04512 |
| Focal adhesion | hsa04510 |
| Hematopoietic cell lineage | hsa04640 |
| Hypertrophic cardiomyopathy (HCM) | hsa05410 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Regulation of actin cytoskeleton | hsa04810 |
| Small cell lung cancer | hsa05222 |
| Toxoplasmosis | hsa05145 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00191 | 413-464 | Int_alpha |
| cl21611 | 413-464 | Int_alpha superfamily |
| smart00191 | 353-406 | Int_alpha |
| cl21611 | 353-406 | Int_alpha superfamily |
| pfam13517 | 363-436 | VCBS |
| cl21563 | 363-436 | VCBS superfamily |
| smart00191 | 40-100 | Int_alpha |
| cl21611 | 40-100 | Int_alpha superfamily |
| pfam01839 | 355-393 | FG-GAP |
| cl21621 | 355-393 | FG-GAP superfamily |
| pfam13517 | 425-491 | VCBS |
| cl21563 | 425-491 | VCBS superfamily |
| smart00191 | 293-345 | Int_alpha |
| cl21611 | 293-345 | Int_alpha superfamily |
| pfam01839 | 423-449 | FG-GAP |
| cl21621 | 423-449 | FG-GAP superfamily |
| smart00191 | 470-493 | Int_alpha |
| cl21611 | 470-493 | Int_alpha superfamily |
| pfam08441 | 503-978 | Integrin_alpha2 |
Ontology Information
| HPRD ID | 1681 |
|---|---|
| Molecular Class | Not Available |
| Molecular Function | Guanyl-nucleotide exchange factor activity (GO:0005085) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.