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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25592039 | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Luciferase reporter assays,Chromatin immunoprecipitation (ChIP) assays. | Down-regulation | - | A positive feedback loop between IRF1 and miR-29b may contribute to the sensitivity of CRC cells to IFN-?. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008] |
| Chromosome | 5 |
| Location | 5q23-q31 |
| Start | 131817301 |
| End | 131826465 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 9165 |
| OMIM ID | 147575 |
| HGNC ID | HGNC:6116 |
| Unigene ID | Hs.436061 |
| Ensembl ID | ENSG00000125347 |
| PharmGKB ID | PA29915 |
mRNA Information
| mRNA ID | NM_002198.2 |
|---|---|
| Exon | join(5..233,1295..1386,2753..2852,3648..3824,3934..3983, 4092..4221,4405..4527,5062..5111,6281..6416,6703..9169) | mRNA Sequence | Download Select all |
| Length | 3567 |
Protein Information
| Protein ID | NP_002189.1 |
|---|---|
| Protein Name | interferon regulatory factor 1 |
| Molecular Wt. (Da) | 36371 |
| Protein Sequence | Download Select all |
| Length | 325 |
| Uniprot ID | Q07889 |
| Ensembl Protein ID | ENSP00000384675 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 62 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2033 | EP300 | 4078 | NP_001420.2 | in vitro | 10438822 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hepatitis C | hsa05160 |
| Pertussis | hsa05133 |
| Prolactin signaling pathway | hsa04917 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00103 | 5-113 | IRF |
| cl00096 | 5-113 | IRF superfamily |
| pfam00605 | 5-114 | IRF |
| smart00348 | 7-114 | IRF |
Ontology Information
| HPRD ID | 8921 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.