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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
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- Pathway
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24752990 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Lentiviral shRNA transduction and proliferation assay and western blotting | Phosphorylation | - | TBK1 has therapeutic potential under certain contexts and phosphorylation of its downstream target IRF3 is a biomarker of TBK1 activity. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Chromosome | 19 |
| Location | 19q13.3-q1 |
| Start | 49659569 |
| End | 49665875 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6307 |
| OMIM ID | 603734 |
| HGNC ID | HGNC:6118 |
| Unigene ID | Hs.731922 |
| Ensembl ID | ENSG00000126456 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001197128.1 |
|---|---|
| Exon | join(1..245,2618..2688,3259..3451,5048..5163,6043..6307) | mRNA Sequence | Download Select all |
| Length | 1642 |
CDS Information
| Location | join(1038..1202,2362..2533,2618..2688,3259..3451, 3548..3928,5032..5163,6043..6287) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS59409.1 |
Protein Information
| Protein ID | NP_001184051.1 |
|---|---|
| Protein Name | interferon regulatory factor 3 |
| Molecular Wt. (Da) | 49004 |
| Protein Sequence | Download Select all |
| Length | 452 |
| Uniprot ID | P19367 |
| Ensembl Protein ID | ENSP00000298649 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 385 |
| S | Phosphorylation | 386 |
| S | Phosphorylation | 396 |
| S | Phosphorylation | 398 |
| S | Phosphorylation | 402 |
| T | Phosphorylation | 404 |
| S | Phosphorylation | 405 |
| S | Phosphorylation | 175 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1387 | CREBBP | 2534 | NP_004371.2 | in vitro;in vivo | 1 052 145 612 473 110 |
| 5055 | SERPINB2 | 1420 | NP_002566.1 | in vitro;in vivo;yeast 2-hybrid | 12883638 |
| 6857 | SYT1 | 1710 | NP_005630.1 | in vitro | 16143103 |
| 9641 | IKBKE | 5442 | NP_054721.1 | in vitro;in vivo | 1 269 254 915 695 820 |
| 29110 | TBK1 | 5322 | NP_037386.1 | in vitro;in vivo | 1 269 254 915 695 820 |
| 51588 | PIAS4 | 6910 | NP_056981.2 | in vivo | 15251447 |
| 57506 | MAVS | 13847 | NP_065797.2 | in vitro;in vivo | 16153868 |
| 64750 | SMURF2 | 6901 | NP_073576.1 | in vivo | 15761153 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytosolic DNA-sensing pathway | hsa04623 |
| Epstein-Barr virus infection | hsa05169 |
| Hepatitis B | hsa05161 |
| Hepatitis C | hsa05160 |
| Herpes simplex infection | hsa05168 |
| Influenza A | hsa05164 |
| Measles | hsa05162 |
| Pertussis | hsa05133 |
| RIG-I-like receptor signaling pathway | hsa04622 |
| Toll-like receptor signaling pathway | hsa04620 |
| Viral carcinogenesis | hsa05203 |
Structure Information
| PDB ID | 1J2F |
|---|---|
| Resolution | 2.3 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B |
| Molecule | Interferon regulatory factor 3 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00103 | 5-110 | IRF |
| cl00096 | 5-110 | IRF superfamily |
| pfam10401 | 202-380 | IRF-3 |
| cl11061 | 202-380 | IRF-3 superfamily |
| smart00348 | 7-112 | IRF |
| pfam00605 | 5-110 | IRF |
| pfam15624 | 86-194 | Mif2_N |
| cl21418 | 86-194 | Mif2_N superfamily |
Ontology Information
| HPRD ID | 877 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | MHC class I receptor activity (GO:0030106); MHC class II receptor activity (GO:0045012) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.