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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21400501 | 2011 | Cell line : - Source : Aarhus University Hospital, Skejby, Denmark. Sample Type : CRC tumor No. of Sample : 6 normal mucosas,6 adenomas and 30 MSI and MSS carcinomas. Stage : TNM Stage I-IV | Whole-genome methylation arrays,Methylation-Sensitive High Resolution Melting analysis, Exon arrays,real time RT-PCR,Immunohistochemistry | Hypermethylation | - | - |
| 26185457 | 2015 | Cell line : HCT116, HT29, SW480, LIM1215 Source : Tissue bank Sample Type : CRC tumor No. of Sample : Non-neoplastic (59), adenoma (13) or adenocarcinoma (95 comprising 24 Dukes A, 18 Dukes B 45 Dukes C and 8 Dukes D) Stage : Duke Stage A-D | Enrichment of methylated DNA fragments and promoter microarray hybridization | Hypermethylation | - | MAPK14, MAPK3, HRAS, YY1, and IRF4 may be considered as potential biomarkers for early diagnosis and therapy of CRC. |
| 24485021 | 2014 | Cell line : - Source : Renji Hospital (Shanghai, People�s Republic of China). Sample Type : CRC tumor andadjecent normal tissue No. of Sample : 2 Stage : - | Bisulfite-Tag genome-wide analysis, multiplexed bisulfite sequencing, methylation specific PCR | Hypomethylation | - | 11 genes (BCAT1, COL4A2, DLX5, FGF5, FOXF1, FOXI2, GRASP, IKZF1, IRF4, SDC2 and SOX21) have very low methylation in peripheral blood DNA and are suitable for further evaluation as blood-based diagnostic markers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010] |
| Chromosome | 6 |
| Location | 6p25-p23 |
| Start | 391739 |
| End | 411443 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 19705 |
| OMIM ID | 601900 |
| HGNC ID | HGNC:6119 |
| Unigene ID | Hs.401013 |
| Ensembl ID | ENSG00000137265 |
| PharmGKB ID | PA29918 |
mRNA Information
| mRNA ID | NM_002460.3 |
|---|---|
| Exon | join(1..71,1360..1630,3083..3269,4109..4197,5370..5514, 7090..7197,9686..10039,13280..13392,15717..19705) | mRNA Sequence | Download Select all |
| Length | 5332 |
Protein Information
| Protein ID | NP_002451.2 |
|---|---|
| Protein Name | interferon regulatory factor 4 |
| Molecular Wt. (Da) | 51642 |
| Protein Sequence | Download Select all |
| Length | 451 |
| Uniprot ID | P48431 |
| Ensembl Protein ID | ENSP00000323588 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 192 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 604 | BCL6 | 180 | NP_620309.1 | in vitro;in vivo | 10601358 |
| 4615 | MYD88 | 3703 | NP_002459.2 | in vivo | 16236719 |
| 4773 | NFATC2 | 2730 | NP_775114.1 | in vitro;in vivo | 11956291 |
| 6688 | SPI1 | 1305 | NP_001074016.1 | in vitro;in vivo | 1 002 284 012 372 320 |
| 6778 | STAT6 | 3302 | NP_003144.3 | in vitro | 10601358 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00103 | 24-129 | IRF |
| cl00096 | 24-129 | IRF superfamily |
| pfam10401 | 249-418 | IRF-3 |
| cl11061 | 249-418 | IRF-3 superfamily |
| pfam00605 | 23-130 | IRF |
| smart00348 | 23-130 | IRF |
| smart00524 | 268-397 | DWB |
| cl00056 | 268-397 | MH2 superfamily |
Ontology Information
| HPRD ID | 1695 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.