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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26096932 | 2015 | Cell line : T84, HT29, SW480, SW620, DLD1, HCT116,Caco-2/15. Source : - Sample Type : - No. of Sample : - Stage : - | MYC inhibition and lentivirus-mediated RNA interference,real-time RT-PCR,western blotting,Chromatin immunoprecipitation and Tissue microarray and immunohistochemistry | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Integrins" |
| Description | This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008] |
| Chromosome | 5 |
| Location | 5q11.1 |
| Start | 52084136 |
| End | 52249485 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 165350 |
| OMIM ID | 192968 |
| HGNC ID | HGNC:6134 |
| Unigene ID | Hs.644352 |
| Ensembl ID | ENSG00000213949 |
| PharmGKB ID | PA29935 |
mRNA Information
| mRNA ID | NM_015946.4 |
|---|---|
| Exon | join(<1..113,11584..12819,13108..14316) | mRNA Sequence | Download Select all |
| Length | 2941 |
Protein Information
| Protein ID | NP_057030.3 |
|---|---|
| Protein Name | integrin, alpha 1 |
| Molecular Wt. (Da) | 43228 |
| Protein Sequence | Download Select all |
| Length | 385 |
| Uniprot ID | P48436 |
| Ensembl Protein ID | ENSP00000245479 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 100 |
| N | Glycosylation | 105 |
| S | Phosphorylation | 541 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1295 | COL8A1 | 372 | NP_001841.2 | in vitro | 1 248 254 510 666 370 |
| 1305 | COL13A1 | 383 | NP_005194.3 | in vivo | 10713152 |
| 3688 | ITGB1 | 628 | NP_391987.1 | in vivo | 8428973 |
| 4146 | MATN1 | 276 | NP_002370.1 | in vitro;in vivo | 10196235 |
| 7094 | TLN1 | 1726 | NP_006280.3 | in vitro;in vivo | 11336656 |
| 284217 | LAMA1 | 1033 | NP_005550.2 | in vitro | 9688542 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | hsa05412 |
| Dilated cardiomyopathy | hsa05414 |
| ECM-receptor interaction | hsa04512 |
| Focal adhesion | hsa04510 |
| Hematopoietic cell lineage | hsa04640 |
| Hypertrophic cardiomyopathy (HCM) | hsa05410 |
| PI3K-Akt signaling pathway | hsa04151 |
| Regulation of actin cytoskeleton | hsa04810 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01469 | 171-351 | vWA_integrins_alpha_subunit |
| cl00057 | 171-351 | vWFA superfamily |
| smart00327 | 172-352 | VWA |
| cd01450 | 171-340 | vWFA_subfamily_ECM |
| pfam00092 | 172-355 | VWA |
| cd01472 | 172-344 | vWA_collagen |
| cd01482 | 172-344 | vWA_collagen_alphaI-XII-like |
| cd01475 | 171-359 | vWA_Matrilin |
| cd00198 | 171-340 | vWFA |
| cd01481 | 172-344 | vWA_collagen_alpha3-VI-like |
| cd01476 | 171-287 | VWA_integrin_invertebrates |
| cd01471 | 171-315 | vWA_micronemal_protein |
| smart00191 | 568-621 | Int_alpha |
| cl21611 | 568-621 | Int_alpha superfamily |
| cd01480 | 171-319 | vWA_collagen_alpha_1-VI-type |
| cd01474 | 167-287 | vWA_ATR |
| smart00191 | 486-529 | Int_alpha |
| cl21611 | 486-529 | Int_alpha superfamily |
| pfam13519 | 172-309 | VWA_2 |
| cd01477 | 170-280 | vWA_F09G8-8_type |
| pfam13517 | 580-651 | VCBS |
| cl21563 | 580-651 | VCBS superfamily |
| pfam01839 | 571-606 | FG-GAP |
| cl21621 | 571-606 | FG-GAP superfamily |
| pfam14312 | 568-606 | FG-GAP_2 |
| cl18683 | 568-606 | FG-GAP_2 superfamily |
| smart00191 | 434-474 | Int_alpha |
| cl21611 | 434-474 | Int_alpha superfamily |
| pfam08441 | 664-1033 | Integrin_alpha2 |
Ontology Information
| HPRD ID | 3483 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.