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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ITGA2 3673 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)  5CD49b 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
18836731   2009Cell line : -

Source : Division of oncology,Department of internal medicine medical University,Graz, Austria.

Sample Type : CRC Tumor

No. of Sample : 433

Stage : -

 5'-nuclease assays.Polymorhpism-The ITGA2 807C>T polymorphism was associated with reduced colorectal cancer risk.


Gene Details



NC_000005.9 (52285156..52390609)

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Gene Type protein coding
Gene Family CD molecules, "Integrins"
Description This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]  
Chromosome 5
Location 5q11.2
Start 52285156  
End 52390609  
Strand +  
Gene Sequence

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Length 105454  
OMIM ID 192974   
HGNC ID HGNC:6137   
Unigene ID Hs.482077   
Ensembl ID ENSG00000164171   
PharmGKB ID PA204   

mRNA Information


mRNA ID NM_002203.3
Exon join(1..207,37423..37543,52787..52896,55676..55767, 59038..59152,59318..59445,62086..62234,66213..66363, 66659..66824,68700..68776,70549..70687,71576..71721, 73461..73604,75587..75790,76516..76652,77793..77932, 80784..80935,82613..82723,83288..83370,83793..83934, 85060..85152,85736..85812,85896..85979,89447..89549, 91186..91296,92267..92371,94015..94128,97627..97716, 100621..100737,101194..105454)  
mRNA Sequence

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Length 7878  



CDS Information


   
Location144..3689
CDS Sequence

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CCDS ID CCDS3957.1



Protein Information


      
Protein IDNP_002194.2
Protein Nameintegrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Molecular Wt. (Da)0
Protein Sequence

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Length 1181  
Uniprot IDQ02447
Ensembl Protein ID ENSP00000310301  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1180
SPhosphorylation1181
TPhosphorylation1177
NGlycosylation1074
NGlycosylation343

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
58ACTA130NP_001091.1in vitro7503723   
1277COL1A1362NP_000079.2in vitro;in vivo11   359   786   118   563   400   000   000   
1278COL1A2363NP_000080.2in vitro2156854   
1295COL8A1372NP_001841.2in vitro1   248   254   510   666   370   
3688ITGB1628NP_391987.1in vitro;in vivo16   907   181   693   624   300   000   000   000   000   
4312MMP1384NP_002412.1in vitro;in vivo1   135   977   411   359   780   
284217LAMA11033NP_005550.2in vitro9688542   


Pathway Information


                                                                              
Pathway Name Pathway ID
Arrhythmogenic right ventricular cardiomyopathy (ARVC) hsa05412
Dilated cardiomyopathy hsa05414
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
Hematopoietic cell lineage hsa04640
Hypertrophic cardiomyopathy (HCM) hsa05410
Pathways in cancer hsa05200
Phagosome hsa04145
PI3K-Akt signaling pathway hsa04151
Platelet activation hsa04611
Proteoglycans in cancer hsa05205
Regulation of actin cytoskeleton hsa04810
Small cell lung cancer hsa05222


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd01469173-353  vWA_integrins_alpha_subunit
cl00057173-353  vWFA superfamily
smart00327174-352  VWA
cd01450173-342  vWFA_subfamily_ECM
pfam00092174-352  VWA
cd01472173-346  vWA_collagen
cd01482174-346  vWA_collagen_alphaI-XII-like
cd00198173-342  vWFA
cd01475173-346  vWA_Matrilin
cd01481174-346  vWA_collagen_alpha3-VI-like
cd01476174-289  VWA_integrin_invertebrates
smart00191551-604  Int_alpha
cl21611551-604  Int_alpha superfamily
cd01471173-288  vWA_micronemal_protein
cd01480169-311  vWA_collagen_alpha_1-VI-type
pfam13519174-350  VWA_2
cd01473174-284  vWA_CTRP
smart00191487-535  Int_alpha
cl21611487-535  Int_alpha superfamily
smart00191614-642  Int_alpha
cl21611614-642  Int_alpha superfamily
smart00191433-475  Int_alpha
cl21611433-475  Int_alpha superfamily
pfam13517563-636  VCBS
cl21563563-636  VCBS superfamily
smart0019147-95  Int_alpha
cl2161147-95  Int_alpha superfamily
pfam01839554-589  FG-GAP
cl21621554-589  FG-GAP superfamily
pfam08441649-1060  Integrin_alpha2


Ontology Information


   
HPRD ID2764
Molecular ClassCell surface receptor
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO