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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ITGA3 3675 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)  17CD49c, VLA3a, VCA-2, GAP-B3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23705994   2013Cell line : -

Source : Department, Barretos Cancer Hospital, Brazil.

Sample Type : CRC Tumor

No. of Sample : 114

Stage : TNM stage I-IV

RT-PCR,tissue microarray.Up-regulation-In relation to TNM staging, ITGB5 and ITGA3 were over-expressed in stages III versus I.


Gene Details



NC_000017.10 (48133340..48167849)

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Gene Type protein coding
Gene Family CD molecules, "Integrins"
Description The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]  
Chromosome 17
Location 17q21.33
Start 48133340  
End 48167849  
Strand +  
Gene Sequence

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Length 34510  
OMIM ID 605025   
HGNC ID HGNC:6139   
Unigene ID Hs.265829   
Ensembl ID ENSG00000005884   
PharmGKB ID PA29939   

mRNA Information


mRNA ID NM_002204.3
Exon join(1..670,8102..8229,8553..8632,12081..12330, 14869..14955,15336..15543,16011..16207,17941..18029, 18169..18305,18473..18559,19484..19551,19624..19760, 20351..20500,20609..20706,20999..21146,21404..21472, 22071..22150,22232..22309,22849..22951,23101..23283, 23460..23582,24287..24400,25335..25433,31769..31894, 32250..32391,33135..34510)  
mRNA Sequence

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Length 5052  



CDS Information


   
Location473..3628
CDS Sequence

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CCDS ID CCDS11558.1



Protein Information


      
Protein IDNP_002195.1
Protein Nameintegrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Molecular Wt. (Da)0
Protein Sequence

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Length 1051  
Uniprot IDQ02446
Ensembl Protein ID ENSP00000222584  



Post-translational Modification Information (Source : HPRD)


Residue Type site
CDisulfide Bridge140;162
CDisulfide Bridge185;197
CDisulfide Bridge615;621
CDisulfide Bridge694;702
CDisulfide Bridge846;904
CDisulfide Bridge911;916
CDisulfide Bridge94;103
CDisulfide Bridge140;162
CDisulfide Bridge185;197
CDisulfide Bridge615;621
CDisulfide Bridge694;702
CDisulfide Bridge846;904
CDisulfide Bridge911;916
CDisulfide Bridge94;103
YPhosphorylation1051;-
NGlycosylation265
NGlycosylation265
SPhosphorylation1042
TPhosphorylation1044

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
274BIN13150NP_647593.1yeast 2-hybrid10094488   
811CALR169NP_004334.1in vivo800   607   311   327   697   
928CD9880NP_001760.1in vitro;in vivo1   006   587   210   694   270   
2274FHL24026NP_001441.4in vitro;yeast 2-hybrid10906324   
2335FN1626NP_997647.1in vivo9733622   
3688ITGB1628NP_391987.1in vitro15254262   
5877RABIF4566NP_002862.2yeast 2-hybrid10094488   
7077TIMP21784NP_003246.1in vivo1   288   791   916   326   700   
7106TSPAN44033NP_003262.1in vivo936   099   610   734   060   


Pathway Information


                                                            
Pathway Name Pathway ID
Arrhythmogenic right ventricular cardiomyopathy (ARVC) hsa05412
Dilated cardiomyopathy hsa05414
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
Hematopoietic cell lineage hsa04640
Hypertrophic cardiomyopathy (HCM) hsa05410
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
Regulation of actin cytoskeleton hsa04810
Small cell lung cancer hsa05222


Structure Information


No matching records could be found.

Domain Information




ID Location Description
smart00191365-417  Int_alpha
cl21611365-417  Int_alpha superfamily
smart00191304-352  Int_alpha
cl21611304-352  Int_alpha superfamily
smart0019148-108  Int_alpha
cl2161148-108  Int_alpha superfamily
pfam13517315-389  VCBS
cl21563315-389  VCBS superfamily
pfam01839307-345  FG-GAP
cl21621307-345  FG-GAP superfamily
pfam01839369-402  FG-GAP
cl21621369-402  FG-GAP superfamily
smart00191430-481  Int_alpha
cl21611430-481  Int_alpha superfamily
pfam13517279-326  VCBS
cl21563279-326  VCBS superfamily
pfam08441462-859  Integrin_alpha2


Ontology Information


   
HPRD ID1631
Molecular ClassCell surface receptor
Molecular FunctionExtracellular matrix structural constituent (GO:0005201)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO