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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ITGA4 | 3676 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 2 | CD49d |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21033217 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 31 healthy controls, 25 adenomas, 30 CRC Stage : - | methylation specific PCR | Methylation | - | ITGA4, SFRP2 and p16 promoter methylation in stool samples had high sensitivity and specificity for the detection of colorectal adenomas and CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Integrins" |
| Description | The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] |
| Chromosome | 2 |
| Location | 2q31-q32 |
| Start | 182321619 |
| End | 182402474 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 80856 |
| OMIM ID | 192975 |
| HGNC ID | HGNC:6140 |
| Unigene ID | Hs.72981 |
| Ensembl ID | ENSG00000115232 |
| PharmGKB ID | PA29940 |
mRNA Information
| mRNA ID | NM_000885.5 |
|---|---|
| Exon | join(1..960,1305..1426,18069..18175,18268..18397, 21866..21933,23246..23375,24707..24792,25469..25531, 25623..25760,28990..29101,36434..36528,37831..37921, 38480..38525,38892..39046,41732..41886,52767..52916, 54808..54884,65300..65450,66546..66641,67280..67359, 68311..68400,70406..70496,72650..72757,73633..73758, 74766..74885,77381..77479,77925..78044,78541..80856) | mRNA Sequence | Download Select all |
| Length | 7281 |
Protein Information
| Protein ID | NP_000876.3 |
|---|---|
| Protein Name | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1032 |
| Uniprot ID | P09486 |
| Ensembl Protein ID | ENSP00000231061 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| R | Proteolytic Cleavage | 591 |
| S | Phosphorylation | 1021 |
| N | Glycosylation | 480 |
| N | Glycosylation | 645 |
| N | Glycosylation | 806 |
| N | Glycosylation | 518 |
| N | Glycosylation | 538 |
| N | Glycosylation | 79 |
| N | Glycosylation | 660 |
| N | Glycosylation | 813 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1462 | VCAN | 340 | NP_004376.2 | in vitro | 11083865 |
| 2335 | FN1 | 626 | NP_997647.1 | in vitro;in vivo | 110 108 129 117 345 |
| 3386 | ICAM4 | 198 | NP_001034221.1 | in vitro | 11435317 |
| 3688 | ITGB1 | 628 | NP_391987.1 | in vitro;in vivo | 1 101 081 214 681 210 |
| 3695 | ITGB7 | 948 | NP_000880.1 | in vivo | 1 268 224 914 681 210 |
| 5573 | PRKAR1A | 1786 | NP_002725.1 | in vivo | 17369818 |
| 7041 | TGFB1I1 | 3831 | NP_001035919.1 | in vitro | 10604475 |
| 8174 | MADCAM1 | 35 | NP_570117.1 | in vitro | 107 022 709 873 398 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | hsa05412 |
| Cell adhesion molecules (CAMs) | hsa04514 |
| Dilated cardiomyopathy | hsa05414 |
| ECM-receptor interaction | hsa04512 |
| Focal adhesion | hsa04510 |
| Hematopoietic cell lineage | hsa04640 |
| Hypertrophic cardiomyopathy (HCM) | hsa05410 |
| Intestinal immune network for IgA production | hsa04672 |
| Leishmaniasis | hsa05140 |
| Leukocyte transendothelial migration | hsa04670 |
| PI3K-Akt signaling pathway | hsa04151 |
| Regulation of actin cytoskeleton | hsa04810 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00191 | 366-418 | Int_alpha |
| cl21611 | 366-418 | Int_alpha superfamily |
| smart00191 | 303-352 | Int_alpha |
| cl21611 | 303-352 | Int_alpha superfamily |
| pfam13517 | 314-388 | VCBS |
| cl21563 | 314-388 | VCBS superfamily |
| smart00191 | 428-479 | Int_alpha |
| cl21611 | 428-479 | Int_alpha superfamily |
| smart00191 | 48-105 | Int_alpha |
| cl21611 | 48-105 | Int_alpha superfamily |
| pfam01839 | 306-342 | FG-GAP |
| cl21621 | 306-342 | FG-GAP superfamily |
| pfam01839 | 371-403 | FG-GAP |
| cl21621 | 371-403 | FG-GAP superfamily |
| pfam13517 | 377-450 | VCBS |
| cl21563 | 377-450 | VCBS superfamily |
| pfam08441 | 463-902 | Integrin_alpha2 |
Ontology Information
| HPRD ID | 1325 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P13612 | DB00108 | Natalizumab | BiotechDrug |
| P13612 | DB06822 | Tinzaparin | SmallMoleculeDrug |
| P13612 | DB09033 | Vedolizumab | BiotechDrug |