Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ITGA5 | 3678 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 12 | CD49e |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23128103 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 114 Stage : TNM stage I-IV | real time RT-PCR and immunohistochemistry | Up-regulation | - | Overexpression of the ITGAV gene and protein was correlated with an increased risk of perineural invasion. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Integrins" |
| Description | The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015] |
| Chromosome | 12 |
| Location | 12q11-q13 |
| Start | 54789045 |
| End | 54813050 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 24006 |
| OMIM ID | 135620 |
| HGNC ID | HGNC:6141 |
| Unigene ID | Hs.505654 |
| Ensembl ID | - |
| PharmGKB ID | PA29941 |
mRNA Information
| mRNA ID | NM_002205.3 |
|---|---|
| Exon | join(1..286,7303..7433,9670..9782,9915..10035, 10313..10374,10466..10511,11032..11157,11391..11435, 11575..11618,13341..13397,13551..13603,13893..14101, 14373..14564,14792..14837,15021..15122,15301..15356, 15488..15642,15943..16080,16217..16284,16937..17087, 17174..17266,17412..17491,17602..17682,17789..17894, 18272..18421,19320..19403,19509..19622,20569..20670, 21780..21902,22891..24006) | mRNA Sequence | Download Select all |
| Length | 4461 |
Protein Information
| Protein ID | NP_002196.3 |
|---|---|
| Protein Name | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
| Molecular Wt. (Da) | 119108 |
| Protein Sequence | Download Select all |
| Length | 1098 |
| Uniprot ID | P10451 |
| Ensembl Protein ID | ENSP00000237623 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 297 |
| N | Glycosylation | 307 |
| N | Glycosylation | 773 |
| N | Glycosylation | 774 |
| N | Glycosylation | 771 |
| N | Glycosylation | 682 |
| N | Glycosylation | 672 |
| N | Glycosylation | 675 |
| S | Phosphorylation | 128 |
| S | Phosphorylation | 127 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1277 | COL1A1 | 362 | NP_000079.2 | in vitro;in vivo | 1693626 |
| 1956 | EGFR | 579 | NP_005219.2 | in vitro;in vivo | 10888683 |
| 2064 | ERBB2 | 1281 | NP_004439.2 | in vivo | 15757908 |
| 2263 | FGFR2 | 1492 | NP_075261.1 | in vitro | 15728256 |
| 2335 | FN1 | 626 | NP_997647.1 | in vitro;in vivo | 1 180 167 992 118 650 000 000 |
| 80781 | COL18A1 | 382 | NP_569711.2 | in vivo | 11158588 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | hsa05412 |
| Bacterial invasion of epithelial cells | hsa05100 |
| Dilated cardiomyopathy | hsa05414 |
| ECM-receptor interaction | hsa04512 |
| Focal adhesion | hsa04510 |
| Hematopoietic cell lineage | hsa04640 |
| Hypertrophic cardiomyopathy (HCM) | hsa05410 |
| MicroRNAs in cancer | hsa05206 |
| Pertussis | hsa05133 |
| Phagosome | hsa04145 |
| PI3K-Akt signaling pathway | hsa04151 |
| Proteoglycans in cancer | hsa05205 |
| Regulation of actin cytoskeleton | hsa04810 |
| Shigellosis | hsa05131 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00191 | 389-443 | Int_alpha |
| cl21611 | 389-443 | Int_alpha superfamily |
| smart00191 | 322-379 | Int_alpha |
| cl21611 | 322-379 | Int_alpha superfamily |
| smart00191 | 56-114 | Int_alpha |
| cl21611 | 56-114 | Int_alpha superfamily |
| pfam13517 | 334-412 | VCBS |
| cl21563 | 334-412 | VCBS superfamily |
| smart00191 | 455-498 | Int_alpha |
| cl21611 | 455-498 | Int_alpha superfamily |
| pfam01839 | 326-368 | FG-GAP |
| cl21621 | 326-368 | FG-GAP superfamily |
| smart00191 | 268-310 | Int_alpha |
| cl21611 | 268-310 | Int_alpha superfamily |
| pfam13517 | 401-476 | VCBS |
| cl21563 | 401-476 | VCBS superfamily |
| pfam01839 | 392-428 | FG-GAP |
| cl21621 | 392-428 | FG-GAP superfamily |
| pfam08441 | 490-921 | Integrin_alpha2 |
Ontology Information
| HPRD ID | 1649 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Structural molecule activity (GO:0005198) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.